CAS 755037-03-7

Regorafenib

Descrizione:

Regorafenib è un farmaco a piccole molecole utilizzato principalmente in oncologia per il trattamento di vari tipi di cancro, inclusi il cancro colorettale e i tumori stromali gastrointestinali. Funziona come un inibitore multi-chinasico, mirando a diverse chinasi tirosina recettoriali coinvolte nella crescita tumorale e nell'angiogenesi, come VEGFR, PDGFR e chinasi RAF. Regorafenib è caratterizzato dalla sua complessa struttura chimica, che include un anello di piridina e un gruppo 4-(metilsulfonil)fenile, contribuendo alla sua attività farmacologica. La sostanza è tipicamente somministrata per via orale ed è nota per la sua moderata solubilità in soluzioni acquose. Il suo meccanismo d'azione implica l'inibizione della proliferazione delle cellule tumorali e l'interruzione del microambiente tumorale, ostacolando così la progressione del cancro. Regorafenib è associato a una serie di effetti collaterali, tra cui affaticamento, ipertensione e disturbi gastrointestinali, richiedendo un attento monitoraggio durante il trattamento. Come terapia mirata, rappresenta un significativo progresso nel trattamento personalizzato del cancro, offrendo opzioni per i pazienti con malattia refrattaria.

Formula: C₂₁H₁₅ClF₄N₄O₃

InChI: InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChI key: InChIKey=FNHKPVJBJVTLMP-UHFFFAOYSA-N

SMILES: O(C=1C=C(C(NC)=O)N=CC1)C2=CC(F)=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2

Sinonimi:

• 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
• 4-[4-[N′-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic acid methylamide
• 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
• Bay 73-4506
• Regorafenib
• Stivarga
• 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
• 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-N-MethylpicolinaMide
• Regafenib
• Regorafenib (BAY 73-4506)
• 4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide
• BAY 73-4506(Regorafenib)
• Reggae sorafenib
• 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide Regorafenib BAY 73-4506
• fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
• Stivarga(regorafenib)
• 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
• Fluoro-Sorafenib
• 4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3-
• 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
• Regorafenib C3X-1410

Regorafenib

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow to Light orange powder to crystal

Peso molecolare: 482.82

Ref: 3B-R0142

2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 482.8154

Ref: IN-DA00ICN3

Regorafenib

CAS: 755037-03-7

Regorafenib

Purezza: ≥98%

Peso molecolare: 482.82g/mol

Ref: 54-BUP17780

Regorafenib

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Purezza: ≥ 98.0% (dried basis)

Colore e forma: White to off-white powder

Peso molecolare: 482.82

Ref: 7W-GP6787

Regorafenib

CAS: 755037-03-7

Formula: C₂₁H₁₅ClF₄N₄O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 482.82

Ref: 4Z-R-078001

Regorafenib

CAS: 755037-03-7

Regorafenib

Purezza: 98%

Peso molecolare: 482.82g/mol

Ref: 54-PC109086

Regorafenib-13C-d3

CAS: 755037-03-7

Formula: C₂₀₁₃CH₁₂D₃ClF₄N₄O₃

Colore e forma: Pink Solid

Peso molecolare: 486.83

Ref: 4Z-R-078002

Regorafenib

CAS: 755037-03-7

Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally

Formula: C₂₁H₁₅ClF₄N₄O₃

Purezza: 98% - 99.95%

Colore e forma: Solid

Peso molecolare: 482.82

Ref: TM-T1792

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide

CAS: 755037-03-7

Purezza: 99.0%

Colore e forma: Solid

Peso molecolare: 482.82000732421875

Ref: 10-F361865

Regorafenib N-β-D-Glucuronide Sodium Salt

Prodotto controllato

CAS: 755037-03-7

Applications Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

Formula: C₂₇H₂₂ClF₄N₄O₉·Na

Colore e forma: Neat

Peso molecolare: 680.92

Ref: TR-R143320

Regorafenib

Prodotto controllato

CAS: 755037-03-7

Applications It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Dual action VEGFR & Raf inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),

Formula: C₂₁H₁₅ClF₄N₄O₃

Colore e forma: Off White Powder

Peso molecolare: 482.82

Ref: TR-R143000

Regorafenib (1-(4-Chloro-3-(trifluoromethyl)phenyl)urea)trimer

Prodotto controllato

CAS: 755037-03-7

Formula: C₄₉H₃₁Cl₃F₁₀N₈O₇

Colore e forma: Neat

Peso molecolare: 1140.163

Ref: TR-R143350

Regorafenib

CAS: 755037-03-7

Multi-kinase inhibitor; inhibits epoxide hydrolase; antineoplastic

Formula: C₂₁H₁₅ClF₄N₄O₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 482.82 g/mol

Ref: 3D-FR16116