CAS 75747-14-7

Tanespimicina

Descrizione:

Tanespimicina, noto anche come 17-AAG (17-Alilamino-17-demetossigeldanamicina), è un derivato sintetico della geldanamicina, un prodotto naturale con notevoli proprietà antitumorali. Funziona principalmente come inibitore della proteina da shock termico 90 (Hsp90), interrompendo l'attività di chaperone di Hsp90, che è cruciale per la stabilità e la funzione di varie proteine oncogeniche. Questo meccanismo porta alla degradazione delle proteine client coinvolte nella proliferazione e sopravvivenza delle cellule tumorali. Tanespimicina mostra un ampio spettro di attività contro vari tipi di cancro, inclusi i tumori al seno, alla prostata e ai polmoni. Il suo profilo di solubilità è moderato e viene generalmente somministrato per via endovenosa a causa delle sue proprietà farmacocinetiche. Il composto ha subito prove cliniche per valutare la sua efficacia e sicurezza nel trattamento del cancro, sebbene il suo uso sia stato limitato da problemi come la tossicità e lo sviluppo di resistenza. In generale, Tanespimicina rappresenta un'area significativa di ricerca nelle terapie mirate contro il cancro, in particolare nel contesto dell'inibizione di Hsp90.

Formula: C₃₁H₄₃N₃O₈

InChI: InChI=1/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9+,18-10-,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1

InChI key: InChIKey=AYUNIORJHRXIBJ-TXHRRWQRSA-N

SMILES: N(CC=C)C1=C2C(=O)C(=CC1=O)NC(=O)\C(\C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(\C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2

Sinonimi:

• (4Z,6E,10E)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8R,9R,12R,13S,14R,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• (8S,9S,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• 17-(Allylamino)-17-demethoxygeldanamycin
• 17-(Allylamino)-17-desmethylgeldanamycin
• 17-(Allylamino)geldanamycin
• 17-Allylaminodemethoxygeldanamycin
• 17-Allylaminogeldanamycin
• 17-Demethoxy-17-(2-propenylamino)geldanamycin
• 17-Demethoxy-17-allylaminogeldanamycin
• 17-N-Allylamino-17-demethoxygeldanamycin
• 17Aag
• 2-Azabicyclo[16.3.1]docosane, geldanamycin deriv.
• A 8476
• Bms 722782
• Cp 127374
• Geldanamycin, 17-demethoxy-17-(2-propenylamino)-
• Kos 953
• NSC 330507
• Tanespimycin
• CP127374,NSC-330507
• Gld-36
• 17-AAG (TanespiMycin)
• 17AAG (17-(AllylaMino)-17-deMethoxy-geldanaMycin)
• 17-DEMETHOXY-17-ALLYLAMINO GELDANAMYCIN
• 17-demethoxy-17-(2-propenylamino)-[(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
• 17-AAG (KOS953)
• Telatinib/ 17-AAG
• 17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN
• 17-AAG, CP 127374
• 17-AAG
• 17-ALLYLAMINO-17-DIMETHOXYGELDANAMYCIN (17-AAG)
• 17-AAG(GeldanaMycin)
• Geldanamycin, 17-allylamino-17-demethoxy-
• Telatinib
• ALLYLAMINOGELDANAMYCIN
• 17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507
• 17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN
• TELATINIB
• 17-AG
• 17-AGG
• 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN (17-AAG)
• 17-AAG,17AAG
• Geldanamycin, des-o-methyl-17-allylamino-

17-(Allylamino)-17-demethoxygeldanamycin, 99%

CAS: 75747-14-7

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis. This Thermo Scient

Formula: C₃₁H₄₃N₃O₈

Purezza: 99%

Colore e forma: Red to dark red, Powder

Peso molecolare: 585.70

Ref: 02-J66960

17-AAG

CAS: 75747-14-7

Formula: C₃₁H₄₃N₃O₈

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 585.6884

Ref: IN-DA005IF5

17-(Allylamino)-17-demethoxygeldanamycin

CAS: 75747-14-7

17-(Allylamino)-17-demethoxygeldanamycin

Formula: C₃₁H₄₃N₃O₈

Purezza: 98% (Typical Value in Batch COA)

Colore e forma: brown solid

Peso molecolare: 585.69g/mol

Ref: 54-BIA4307

Tanespimycin

CAS: 75747-14-7

Tanespimycin

Purezza: ≥98%

Peso molecolare: 585.69g/mol

Ref: 54-BUP11464

17-Allylamino-17-Demethoxygeldanamycin-d5

CAS: 75747-14-7

Formula: C₃₁H₃₈D₅N₃O₈

Peso molecolare: 590.73

Ref: 4Z-G-165003

Telatinib

CAS: 75747-14-7

Formula: C₃₁H₄₃N₃O₈

Purezza: ≥ 98%

Colore e forma: Red to dark red powder

Peso molecolare: 585.69

Ref: 7W-GA5905

17-Allylamino-17-Demethoxygeldanamycin

CAS: 75747-14-7

Formula: C₃₁H₄₃N₃O₈

Peso molecolare: 585.70

Ref: 4Z-G-165002

Tanespimycin

CAS: 75747-14-7

Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!

Formula: C₃₁H₄₃N₃O₈

Purezza: 98.24% - 99.83%

Colore e forma: Dark Purple Solid

Peso molecolare: 585.69

Ref: TM-T6290

17-(Allylamino-d5) Geldanamycin

Prodotto controllato

CAS: 75747-14-7

Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),

Formula: C₃₁D₅H₃₈N₃O₈

Colore e forma: Neat

Peso molecolare: 590.719

Ref: TR-A549652

17-AAG

CAS: 75747-14-7

M01354 - 17-AAG

Formula: C₃₁H₄₃N₃O₈

Purezza: 98+%

Colore e forma: Solid

Peso molecolare: 585.698

Ref: 10-M01354

17-Allylaminogeldanamycin

CAS: 75747-14-7

17-AAG is the first clinically tested hsp90 inhibitor that exhibits antitumor activity. Its antitumor effects are documented in vivo for various animal models, including erbB2-dependent breast cancer, prostate cancer models, and melanoma.

Formula: C₃₁H₄₃N₃O₈

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 585.69 g/mol

Ref: 3D-AA17307

17-(Allylamino) Geldanamycin

CAS: 75747-14-7

Applications Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than Geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.
References Schnur, R.C., et al.: J. Med. Chem., 38, 3806 (1995), Nimmanapalli, R., et al.: Cancer Res., 61, 1799 (2001), Basso, A.D., et al.: Oncogene, 21, 1159 (2002),

Formula: C₃₁H₄₃N₃O₈

Colore e forma: Neat

Peso molecolare: 585.69

Ref: TR-A549650