CAS 76-66-4

Rincofilina

Descrizione:

Rincofilina è un alcaloide derivato principalmente dalla specie vegetale Uncaria rhynchophylla, comunemente nota come artiglio del diavolo. È caratterizzato dalla sua complessa struttura chimica, che include un telaio tetraciclico. Rincofilina presenta una gamma di proprietà farmacologiche, tra cui effetti neuroprotettivi, anti-infiammatori e analgesici. È stato studiato per le sue potenziali applicazioni terapeutiche in condizioni come l'ipertensione e le malattie neurodegenerative. Il composto interagisce con vari sistemi di neurotrasmettitori, influenzando particolarmente il sistema nervoso centrale. Inoltre, Rincofilina ha mostrato promesse nella modulazione dei canali del calcio e potrebbe possedere proprietà antiossidanti. La sua solubilità è generalmente bassa in acqua, ma può variare in solventi organici. Come molti alcaloidi, il profilo di sicurezza e i potenziali effetti collaterali di Rincofilina richiedono ulteriori indagini, in particolare nell'uso a lungo termine o a dosi elevate. In generale, Rincofilina rappresenta un'area significativa di interesse nella chimica dei prodotti naturali e nella farmacologia, giustificando ulteriori ricerche per chiarire completamente i suoi meccanismi d'azione e il potenziale terapeutico.

Formula: C₂₂H₂₈N₂O₄

InChI: InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13-/t14-,15-,19?,22?/m0/s1

InChI key: InChIKey=DAXYUDFNWXHGBE-KAXDATADSA-N

SMILES: O=C1[C@@]2([C@]3(N(CC2)C[C@H](CC)[C@@H](\C(\C(OC)=O)=C/OC)C3)[H])C=4C(N1)=CC=CC4

Sinonimi:

• Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7β,16E,20α)-
• Mitrinermin
• Mitrinermine
• NSC 21731
• Rhyncholphylline
• Rhynchophyllin
• Rhyncophylline
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1′R,6′R,7′S,8′aS)-
• Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, 6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, [1′R-[1′α,6′β,7′α(E),8′aβ]]-
• methyl (16Z)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (3xi,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (3xi,16Z,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• methyl (7beta,16E,20alpha)-16-(methoxymethylidene)-2-oxocorynoxan-17-oate
• Rhynchophylline
• UNCARINE D(P)
• (7R,16E,20R)-16,17-Didehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
• Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester, (αE,1'R,6'R,7'S,8'aS)-
• 16e,20-alpha)-(7-bet

Rhynchophylline

CAS: 76-66-4

Formula: C₂₂H₂₈N₂O₄

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 384.48

Ref: 3B-R0105

Rhynchophylline

CAS: 76-66-4

Rhynchophylline

Purezza: ≥98%

Peso molecolare: 384.47g/mol

Ref: 54-BUP02284

Rhynchophylline

CAS: 76-66-4

Formula: C₂₂H₂₈N₂O₄

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 384.47

Ref: 7W-GP0939

Rhynchophylline

CAS: 76-66-4

Rhynchophylline

Purezza: 98%

Peso molecolare: 384.47g/mol

Ref: 54-OR1023242

Rhynchophylline

CAS: 76-66-4

Rhynchophylline, a noncompetitive antagonist of the NMDA receptor, which has anti-inflammatory, anti-hypertension, cardiacprotective and neuroprotective activities. Rhynchophylline can markedly inhibit rabbit platelet aggregation induced by ADP or thrombin possibly by depressing the inflow of Ca2+ and the rise of the cytoplasmic free calcium level in platelet.Rhynchophylline can reduce the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) significantly, decrease plasma Ang II, ADMA, and AT1R levels, and promote serum NO and NOS levels, which has the protection of vascular endothelial function.

Formula: C₂₂H₂₈N₂O₄

Purezza: 95%~99%

Peso molecolare: 384.476

Ref: BP-BP1216

Rhynchophylline

CAS: 76-66-4

Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.

Formula: C₂₂H₂₈N₂O₄

Purezza: 99.44% - 99.98%

Colore e forma: Red Brown Or White Fine Powder

Peso molecolare: 384.47

Ref: TM-T6S0659

Rhynchophylline

CAS: 76-66-4

Formula: C₂₂H₂₈N₂O₄

Peso molecolare: 384.48

Ref: 4Z-R-173001

Rhynchophylline

CAS: 76-66-4

Natural alkaloid

Formula: C₂₂H₂₈N₂O₄

Purezza: ≥ 90.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 384.48

Ref: 5G-80526

Rhynchophylline

CAS: 76-66-4

Applications Rhynchophylline is a novel erythropoietin-producing hepatocellular A4 (EphA4) inhibitor.
References Fu, A K.Y., et. al.: P. Natl. Acad. Sci. USA., 111, 9959 (2014)

Formula: C₂₂H₂₈N₂O₄

Colore e forma: Neat

Peso molecolare: 384.47

Ref: TR-R414180

Rhynchophylline

CAS: 76-66-4

Rhynchophylline is an indole alkaloid, which is naturally sourced from the Uncaria genus, specifically from Uncaria rhynchophylla. This alkaloid exhibits its mode of action primarily through non-competitive inhibition of NMDA receptors and L-type calcium channels. It has been observed to modulate both glutamatergic and serotonergic signaling pathways, which underscores its potential neurological impacts.

Formula: C₂₂H₂₈N₂O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 384.47 g/mol

Ref: 3D-FR42770

Rhynchophylline - Bio-X ™

CAS: 76-66-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₂₈N₂O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 384.47 g/mol

Ref: 3D-BR300119