CAS 76410-58-7

L-p-Boronofenilalanina

Descrizione:

L-p-Boronofenilalanina (BPA) è un derivato di aminoacido contenente boro della fenilalanina, caratterizzato dalla presenza di un atomo di boro attaccato al gruppo fenile. È principalmente riconosciuto per le sue potenziali applicazioni nella terapia di cattura dei neutroni di boro (BNCT), un trattamento mirato per il cancro che sfrutta le proprietà uniche del boro per distruggere selettivamente le cellule tumorali quando esposte a radiazioni neutroniche. BPA è tipicamente un solido cristallino bianco a bianco sporco, solubile in acqua e vari solventi organici, il che facilita il suo utilizzo nei sistemi biologici. Il composto presenta proprietà tipiche degli aminoacidi, inclusa la capacità di partecipare alla formazione di legami peptidici e interazioni con recettori biologici. La sua funzionalità unica del boro consente interazioni specifiche in ambienti biologici, rendendolo un argomento di interesse in chimica medicinale e ricerca sul cancro. Inoltre, la stabilità e la reattività di L-p-Boronofenilalanina possono essere influenzate da pH e temperatura, che sono fattori importanti da considerare nelle applicazioni terapeutiche.

Formula: C₉H₁₂BNO₄

InChI: InChI=1/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1

InChI key: InChIKey=NFIVJOSXJDORSP-QMMMGPOBSA-N

SMILES: C([C@@H](C(O)=O)N)C1=CC=C(B(O)O)C=C1

Sinonimi:

• 10B-Bpa
• 4-(Dihydroxyboranyl)Phenylalanine
• 4-(Dihydroxyboryl)-<span class="text-smallcaps">L</span>-phenylalanine
• 4-(dihydroxyboranyl)-L-phenylalanine
• 4-Borono-<span class="text-smallcaps">L</span>-phenylalanine
• 4-Boronophenylalanine
• 4-Dihydroxyborylphenylalanine
• <span class="text-smallcaps">L</span>-BPA
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-borono-
• <span class="text-smallcaps">L</span>-p-Boronophenylalanine
• L-Phenylalanine, 4-borono-
• para-Borono-L-phenylalanine
• para-Boronophenylalanine
• 4-(Dihydroxyboryl)-L-phenylalanine
• 4-Borono-L-phenylalanine
• L-BPA
• L-p-Boronophenylalanine
• 4-BORONO-L-PHENYLALANINE B10 ENRICHED
• L-4-PHENYLALANINEBORONIC ACID
• (S)-(4-BORONIC ACID)-PHENYLALANINE
• 4-L-BPA
• 4-Dihydroxyboryl-L-phenylalanine, L-BPA
• L-PHE[B(OH)2]

4-Borono-L-phenylalanine (contains varying amounts of Anhydride)

CAS: 76410-58-7

Formula: C₉H₁₂BNO₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 209.01

Ref: 3B-B6405

(S)-2-Amino-3-(4-boronophenyl)propanoic acid

CAS: 76410-58-7

Formula: C₉H₁₂BNO₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 209.0069

Ref: IN-DA005Y45

4-Borono-L-phenylalanine

CAS: 76410-58-7

4-Borono-L-phenylalanine

Purezza: ≥95%

Peso molecolare: 209.01g/mol

Ref: 54-BUP17237

4-Borono-L-phenylalanine

CAS: 76410-58-7

Peso molecolare: 209.01

Ref: 7W-GM4799

L-4-(2-Amino-2-carboxyethyl)benzeneboronic acid

CAS: 76410-58-7

L-4-(2-Amino-2-carboxyethyl)benzeneboronic acid

Formula: C₉H₁₂BNO₄

Purezza: ≥95%

Colore e forma: white solid

Peso molecolare: 209.01g/mol

Ref: 54-OR60018

4-Borono-L-phenylalanine

CAS: 76410-58-7

4-Borono-L-phenylalanine: antitumor agent for melanoma, glioblastoma trials in boron neutron capture therapy.

Formula: C₉H₁₂BNO₄

Purezza: 96.45%

Colore e forma: Solid

Peso molecolare: 209.01

Ref: TM-T77706

4-Borono-L-phenylalanine

Prodotto controllato

CAS: 76410-58-7

Applications 4-Borono-L-phenylalanine is an unnatural derivative of L-Phenylalanine (P319415). a nonpolar, essential amino acid that naturally occurs in the human body and is also used to treat patients with depression. 4-Borono-L-phenylalanine is also being used as a mediator in sequential boron neutron capture therapy, a new method of treating oral cancer.
References Birkmayer, W., et al.: J. Neural Transm., 59, 81 (1984); Johnson, D.,et al.: Nat. Chem. Biol., 7, 779 (2011); Kankaanranta, L., et al.: Int. J. Radiat. Oncol., 80, 369 (2011); Molinari, A., et al.: Radiat. Res., 175, 463 (2011)

Formula: C₉H₁₂BNO₄

Colore e forma: Neat

Peso molecolare: 209.01

Ref: TR-B675600

4-Borono-L-phenylalanine

CAS: 76410-58-7

4-Borono-L-phenylalanine is a boron-containing compound that has been used to study the biological effects of radiation. 4-Borono-L-phenylalanine is an analytical tool for measuring neutron scattering and other physical properties. It has also been used as a biochemical probe in studies of DNA duplexes. 4-Borono-L-phenylalanine is toxic to cells, inhibiting protein synthesis, and it can induce apoptosis in tumor cells. In experimental models, 4-borono-L phenylalanine can be administered orally or intravenously and has shown acute toxicity in animals at doses of up to 1000 mg/kg body weight.

Formula: C₉H₁₂BNO₄

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 209.01 g/mol

Ref: 3D-FB139059

L-4-Phenylalanineboronic acid

CAS: 76410-58-7

Formula: C₉H₁₂BNO₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 209.01

Ref: 10-F011054