CAS 76429-85-1

10-Deacetilcefalomannina

Descrizione:

10-Deacetilcefalomannina è un alcaloide naturale derivato dalla specie vegetale *Cephalotaxus*, comunemente nota come tasso prugna. È caratterizzato dalla sua complessa struttura molecolare, che include un nucleo tetraciclico tipico dei derivati della cephalotaxina. Questo composto è notevole per le sue potenziali proprietà farmacologiche, in particolare nel campo dell'oncologia, poiché mostra attività citotossica contro diverse linee cellulari tumorali. La sostanza è spesso studiata per il suo ruolo nello sviluppo di agenti antitumorali, poiché può inibire la proliferazione cellulare e indurre apoptosi nelle cellule maligne. Inoltre, 10-Deacetilcefalomannina è stato indagato per i suoi effetti sul sistema immunitario e il suo potenziale utilizzo nel trattamento di altre malattie. La sua solubilità e stabilità in diversi solventi possono variare, influenzando la sua biodisponibilità e l'efficacia terapeutica. Come per molti alcaloidi, i profili di sicurezza e tossicità sono considerazioni essenziali nella sua applicazione, richiedendo una ricerca approfondita e una valutazione clinica prima dell'uso terapeutico.

Formula: C₄₃H₅₁NO₁₃

InChI: InChI=1S/C43H51NO13/c1-8-22(2)37(50)44-31(25-15-11-9-12-16-25)33(48)39(52)55-27-20-43(53)36(56-38(51)26-17-13-10-14-18-26)34-41(7,35(49)32(47)30(23(27)3)40(43,5)6)28(46)19-29-42(34,21-54-29)57-24(4)45/h8-18,27-29,31-34,36,46-48,53H,19-21H2,1-7H3,(H,44,50)/b22-8+/t27-,28-,29+,31-,32+,33+,34-,36-,41+,42-,43+/m0/s1

InChI key: InChIKey=ADDGUHVEJPNWQZ-GJKIWTKTSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(/C(=C/C)/C)=O)C6=CC=CC=C6)O)=O)C5)[H]

Sinonimi:

• 10-Deacetylcephalomannine
• 10-Deacetyltaxol B
• 10β-Deacetylcephalomanine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• Benzenepropanoic acid, α-hydroxy-β-[(2-methyl-1-oxo-2-butenyl)amino]-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α[αR*,βS*(E)],11α,12α,12aα,12bα]]-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-butenyl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• benzenepropanoic acid, alpha-hydroxy-beta-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-

10-Deacetylcephalomannine

CAS: 76429-85-1

10-Deacetylcephalomannin exhibits activity against PS leukemia in vivo; however, its instability leads to an equilibrium mixture with its cytotoxic C-7 epimer. Additionally, 10-Deacetylcephalomannine demonstrates growth inhibitory effects on human cancer cell lines, including cervical HeLa adenocarcinoma.

Formula: C₄₃H₅₁NO₁₃

Colore e forma: Solid

Peso molecolare: 789.9

Ref: TM-TN7414

10-Deacetyl Cephalomannine

CAS: 76429-85-1

Formula: C₄₃H₅₁NO₃

Peso molecolare: 789.88

Ref: 4Z-C-11905

10-Deacetyl Cephalomannine(>85%)

CAS: 76429-85-1

Applications 10-Deacetyl Cephalomannine is a derivative of Cephalomannine (C258500).
References Liu, J., et al.: J. Pharm. Biomed. Anal., 15, 1729 (1997), Montero, A., et al.: Lancet Oncol., 6, 229 (2005), Ojima, I., et al.: J. Nat. Prod. 72, 554 (2009),

Formula: C₄₃H₅₁NO₁₃

Colore e forma: Neat

Peso molecolare: 789.86

Ref: TR-D198650

10-Deacetyl cephalomannine

CAS: 76429-85-1

10-Deacetyl cephalomannine is a taxane derivative that has been isolated from the needles of Taxus cuspidata. This compound is metabolized by human liver enzymes, such as cytochrome P450, to 10-deacetyltaxol (10-DT). 10-DT has shown antitumor activity in vitro and in vivo against human cancer cell lines. It also inhibits the growth of Mycobacterium tuberculosis in culture. The mechanism of action for this compound is not known, but it may inhibit protein synthesis or cell division. 10-DT inhibits the growth of cancer cells by binding to tubulin and inhibiting microtubule polymerization.

Formula: C₄₃H₅₁NO₁₃

Purezza: Min. 95%

Peso molecolare: 789.86 g/mol

Ref: 3D-FD20817

N-Tigloyl Docetaxel

CAS: 76429-85-1

Formula: C₄₃H₅₁NO₁₃

Peso molecolare: 789.9

Ref: ST-EA-CP-D32046

10-Deacetyl Cephalomannine

CAS: 76429-85-1

Formula: C₄₃H₅₁NO₁₃

Peso molecolare: 789.87

Ref: ST-EA-CP-C548001