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CAS 764667-65-4
:1-[5,6-Diidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-1,3-butanodione
Descrizione:
1-[5,6-Diidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-1,3-butanodione, con numero CAS 764667-65-4, è un composto organico sintetico caratterizzato dalla sua struttura complessa, che include un moiety di triazolo e pirazina. Questo composto presenta più gruppi trifluorometilici, contribuendo alle sue uniche proprietà chimiche, come una maggiore lipofilia e potenziale attività biologica. La presenza del gruppo funzionale butanedione suggerisce che potrebbe partecipare a varie reazioni chimiche, inclusa la condensazione e l'aggiunta di Michael. La sua struttura molecolare indica potenziali applicazioni in chimica medicinale, in particolare nello sviluppo di farmaci mirati a specifiche vie biologiche. I gruppi trifluorometilici possono migliorare la stabilità metabolica e influenzare l'interazione del composto con obiettivi biologici. In generale, questo composto esemplifica il design intricato spesso impiegato nella scoperta di farmaci, dove le modifiche al telaio molecolare possono portare a una maggiore efficacia e selettività nelle applicazioni terapeutiche.
Formula:C16H12F6N4O2
InChI:InChI=1S/C16H12F6N4O2/c17-10-6-12(19)11(18)4-8(10)3-9(27)5-14(28)25-1-2-26-13(7-25)23-24-15(26)16(20,21)22/h4,6H,1-3,5,7H2
InChI key:InChIKey=QAEDTLFWHIEVPK-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C=1N2C(CN(C(CC(CC3=C(F)C=C(F)C(F)=C3)=O)=O)CC2)=NN1
Sinonimi:- (2Z)-1-[3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butane-1,3-dione
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[1,3-dioxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-
- 1,3-Butanedione, 1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-
- 1-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
- 1-(3-Trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluoro-phenyl)-butan-1,3-dione
- 1-[3-(Trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butane-1,3-dione
- 1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1,3-butanedione
- 4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butane-2-one
- 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
- 7-[1,3-Dioxo-4-(2,4,5-trifluorophenyl)butyl]-3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
- Prositagliptin ketone
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10 prodotti.
1-[5,6-DIHYDRO-3-(TRIFLUOROMETHYL)-1,2,4-TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-4-(2,4,5-TRIFLUOROPHENYL)-1,3-BUTANEDIONE
CAS:Purezza:95%Colore e forma:Liquid, OilPeso molecolare:406.287994384766Sitagliptin Ketone (1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione)
CAS:Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFormula:C16H12F6N4O2Colore e forma:Beige SolidPeso molecolare:406.08644(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
CAS:Formula:C16H12F6N4O2Purezza:95%Colore e forma:SolidPeso molecolare:406.2825Sitagliptin Impurity 42
CAS:Formula:C16H12F6N4O2Colore e forma:Pale Yellow SolidPeso molecolare:406.291-(3-(Trifluoromethyl)-5,6-Dihydro-[1,2,4]Triazolo[4,3-A]Pyrazin-7(8H)-Yl)-4-(2,4,5-Trifluorophenyl)Butane-1,3-Dione
CAS:1-(3-(Trifluoromethyl)-5,6-Dihydro-[1,2,4]Triazolo[4,3-A]Pyrazin-7(8H)-Yl)-4-(2,4,5-Trifluorophenyl)Butane-1,3-DionePurezza:98%Peso molecolare:406.28g/mol4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one
CAS:Prodotto controllatoApplications Sitagliptin intermediate.
References Mohri, K., et al.: Chem. Pharm. Bull., 30, 3097 (1982), Cameron, M., et al.: J. Pharm. Biomed. Anal., 28, 137 (2002),Formula:C16H12F6N4O2Colore e forma:NeatPeso molecolare:406.28Sitagliptin keto amide impurity
CAS:Sitagliptin Keto Amide Impurity is a research and development impurity standard that has been shown to be an impurity in the drug product Sitagliptin. It is a synthetic, analytical impurity that has been shown to be present in the drug product at 0.1% of the total weight. This impurity is soluble in water and ethanol, but insoluble in ether, chloroform, benzene, and dichloromethane. The CAS number for this compound is 764667-65-4. Sitagliptin Keto Amide Impurity can be used as an analytical reference material or as a pharmacopoeia reference standard for HPLC analysis of sitagliptin keto amide and its metabolites.
Formula:C16H12F6N4O2Purezza:Min. 95%Colore e forma:Slightly Yellow PowderPeso molecolare:406.28 g/mol4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one-d4
CAS:Prodotto controllatoApplications Isotope labelled Sitagliptin (S491000) intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.
References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)Formula:C16H8D4F6N4O2Colore e forma:NeatPeso molecolare:410.31Ref: ST-EA-CP-S3029
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