CAS 7665-99-8

cGMP

Descrizione:

La sostanza chimica nota come cGMP, o monofosfato di guanosina ciclico, è un nucleotide che svolge un ruolo cruciale come messaggero secondario in vari processi biologici. È coinvolto in vie di segnalazione che regolano numerose funzioni fisiologiche, tra cui la vasodilatazione, la neurotrasmissione e la crescita cellulare. cGMP è sintetizzato a partire da trifosfato di guanosina (GTP) dall'enzima guanilato ciclasi ed è degradato da fosfodiesterasi. Strutturalmente, cGMP presenta un gruppo fosfato ciclico, che lo distingue dal suo omologo lineare, GMP. Questa struttura ciclica consente a cGMP di trasmettere segnali in modo efficace all'interno delle cellule. La sostanza è solubile in acqua e mostra stabilità in condizioni fisiologiche, sebbene possa essere sensibile all'idrolisi in determinati ambienti. Il ruolo di cGMP nel sistema cardiovascolare, in particolare nel rilassamento della muscolatura liscia e nella regolazione della pressione sanguigna, evidenzia la sua importanza in farmacologia e nelle applicazioni terapeutiche. Il suo numero CAS, 7665-99-8, è spesso utilizzato per l'identificazione in database chimici e contesti normativi.

Formula: C₁₀H₁₂N₅O₇P

InChI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=ZOOGRGPOEVQQDX-UUOKFMHZSA-N

SMILES: O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H])NC(N)=N1

Sinonimi:

• 3',5'-(Hidrogenofosfato) Ciclico De Guanosina
• 3',5'-(Hydrogenophosphate) Cyclique De Guanosine
• 3',5'-Cyclic GMP
• 3',5'-Gmp
• 3′,5′-Cyclic GMP
• 3′,5′-Gmp
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, guanosine deriv.
• Cyclic 3',5'-GMP
• Cyclic 3',5'-guanylic acid
• Cyclic 3′,5′-GMP
• Cyclic 3′,5′-guanylic acid
• Cyclic GMP
• Cyclic guanosine 3',5'-monophosphate
• Cyclic guanosine 3′,5′-monophosphate
• Cyclic guanosine monophosphate
• Guanosin-cyclisch-3',5'-(hydrogenphosphat)
• Guanosine 3',5'-monophosphate
• Guanosine 3',5'-phosphate
• Guanosine 3',5'-phosphate (cyclic)
• Guanosine 3′,5′-monophosphate
• Guanosine 3′,5′-phosphate
• Guanosine 3′,5′-phosphate (cyclic)
• Guanosine cyclic 3',5'-monophosphate
• Guanosine cyclic 3',5'-phosphate
• Guanosine cyclic 3′,5′-monophosphate
• Guanosine cyclic 3′,5′-phosphate
• Guanosine, cyclic 3′,5′-(hydrogen phosphate)

Guanosine 3',5'-monophosphate

CAS: 7665-99-8

Formula: C₁₀H₁₂N₅O₇P

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 345.2053

Ref: IN-DA005W1X

Cyclic GMP

CAS: 7665-99-8

Cyclic GMP is an endogenous second messenger that initiates interferon production in response to cytoplasmic DNA. It activates the stimulator of interferon genes (STING), triggering a signaling cascade that results in the production of type I interferons and other immune mediators. The conjugate of cyclic GMP and AMP, known as Cyclic-GMP-AMP, can induce the phosphorylation and nuclear translocation of IRF3, thereby enhancing antiviral immune responses. Additionally, Cyclic GMP may activate PDE to degrade cAMP, inhibit the myocardial calcium current ICa, and regulate cardiac contractility. The derivative 8-Br-cGMP exhibits antiplatelet activity, and Cyclic GMP is used in research related to antiviral immunity and cardiovascular diseases.

Formula: C₁₀H₁₂N₅O₇P

Colore e forma: Solid

Peso molecolare: 345.205

Ref: TM-TN9056

2-Amino-9-((4Ar,6R,7R,7As)-2,7-Dihydroxy-2-Oxidotetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-6-Yl)-1,9-Dihydro-6H-Purin-6-One

CAS: 7665-99-8

2-Amino-9-((4Ar,6R,7R,7As)-2,7-Dihydroxy-2-Oxidotetrahydro-4H-Furo[3,2-D][1,3,2]Dioxaphosphinin-6-Yl)-1,9-Dihydro-6H-Purin-6-One

Purezza: 99%

Peso molecolare: 345.21g/mol

Ref: 54-OR1030896

Guanosine 3'',5''-cyclic monophosphate

CAS: 7665-99-8

Formula: C₁₀H₁₂N₅O₇P

Purezza: (HPLC) ≥ 98.0%

Colore e forma: White powder

Peso molecolare: 345.21

Ref: 7W-GN9625

cGMP

CAS: 7665-99-8

Formula: C₁₀H₁₂N₅O₇P

Purezza: >92.0%(qNMR)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 345.21

Ref: 3B-G0666

Guanosine 3,5-Cyclic Monophosphate

CAS: 7665-99-8

Formula: C₁₀H₁₂N₅O₇P

Peso molecolare: 345.21

Ref: 4Z-G-2444

Guanosine 3',5'-cyclic monophosphate

CAS: 7665-99-8

Guanosine 3',5'-cyclic monophosphate (cGMP) is a nucleotide that functions as a second messenger in the cell. It is involved in many cellular processes, including mitochondrial functions and energy metabolism. cGMP is synthesized from guanosine triphosphate (GTP) by the enzyme guanine nucleotide-binding protein, which hydrolyzes the phosphate group from GTP to form cGMP. cGMP has been shown to be involved in neuronal death, axonal growth, and glucose uptake in cells. Optimum concentrations of cGMP have been found to be between 1-10 μM. It has also been shown to be an important mediator of cyclic axonal growth and bowel disease. Guanosine 3',5'-cyclic monophosphate can also act as a polymerase chain reaction primer for DNA amplification in vitro.

Formula: C₁₀H₁₂N₅O₇P

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 345.21 g/mol

Ref: 3D-NG03522

Guanosine 3′,5′-monophosphate

CAS: 7665-99-8

Formula: C₁₀H₁₂N₅O₇P

Purezza: 98%

Colore e forma: Liquid

Peso molecolare: 345.208

Ref: 10-F329441

Guanosine 3',5'-Cyclic Monophosphate

Prodotto controllato

CAS: 7665-99-8

Stability Hygroscopic
Applications Guanosine 3',5'-cyclic monophosphate is an intracellular second messenger which are involved in the transduction of a diverse array of stimuli, mediating metabolic and growth regulation.
References Aladelokun, O., et al.: Curr. Drug Metab., 18, 1132-1135 (2017)

Formula: C₁₀H₁₂N₅O₇P

Colore e forma: Neat

Peso molecolare: 345.205

Ref: TR-G838710