CAS 76712-82-8

des-gly10,(D-his(bzl)6)-lh-rh*etilamide

Descrizione:

des-gly10,(D-his(bzl)6)-lh-rh*etilamide, con il numero CAS 76712-82-8, è un analogo di peptide sintetico derivato dall'ormone che si verifica naturalmente, l'ormone di rilascio dell'ormone luteinizzante (LHRH). Questo composto è caratterizzato dalle sue modifiche strutturali, che includono la rimozione del residuo di glicina nella posizione 10 e l'incorporazione di un residuo di D-istidina con un gruppo benzilico nella posizione 6. Queste modifiche migliorano la sua stabilità e bioattività rispetto all'LHRH nativo. Il composto generalmente mostra alta affinità per i recettori di LHRH, rendendolo di interesse nella ricerca relativa alla biologia riproduttiva e alle potenziali applicazioni terapeutiche nei disturbi ormonali. La sua struttura unica consente un'azione prolungata nei sistemi biologici, il che può essere vantaggioso in contesti clinici. Come peptide, è generalmente solubile in soluzioni acquose e potrebbe richiedere condizioni specifiche per lo stoccaggio e la manipolazione per mantenere la sua integrità. In generale, des-gly10,(D-his(bzl)6)-lh-rh*etilamide rappresenta un significativo progresso nel design dei peptidi per terapie ormonali mirate.

Formula: C₆₆H₈₆N₁₈O₁₂

InChI: InChI=1/C66H86N18O12.C2H4O2/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47;1-2(3)4/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71);1H3,(H,3,4)/t47-,48-,49-,50-,51-,52-,53+,54-,55-;/m0./s1

Sinonimi:

• Histrelin
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
• ^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
• 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
• (n-ethyl-l-prolinamide)-10-deglycinamide-
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
• Supprelin
• Histreline Acetate
• histrelin acetate
• 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
• 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
• RWJ-17070
• DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
• ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
• orf17070
• (HIS(BZL)6)-HISTRELIN
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
• Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
• PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET

Histrelin

CAS: 76712-82-8

Formula: C₆₆H₈₆N₁₈O₁₂

Peso molecolare: 1323.50

Ref: 7W-GP6870

Histrelin

CAS: 76712-82-8

Formula: C₆₆H₈₆N₁₈O₁₂

Peso molecolare: 1323.53

Ref: 4Z-PH-047001

Histrelin Acetate

CAS: 76712-82-8

Formula: C₆₆H₈₆N₁₈O₁₂

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 1323.5

Ref: BP-BPPG040

Histrelin Acetic Acid Salt

CAS: 76712-82-8

Applications Histrelin is a gonadotropin releasing hormone analog used with the potential to improve height prospects.
References Brauner, R. et al.: Nat. Rev. Endocrinol., 11, 386 (2015);

Formula: C₆₆H₈₆N₁₈O₁₂•xCH₃COOH

Colore e forma: Neat

Peso molecolare: 1323.506005

Ref: TR-H456310

Histrelin Acetate

CAS: 76712-82-8

Histrelin acetate is a synthetic analog of the natural hormone histrelin. It has been used clinically to treat prostate cancer, androgenetic alopecia, and other conditions. Histrelin acetate binds to receptors in the hypothalamus and pituitary gland that are responsible for regulating the production of sex hormones. This drug is administered by injection into the pubic area or under the skin as an implant. Histrelin acetate's effectiveness is related to its suppression of gonadotropins, which results in decreased testosterone levels. Histrelin acetate also decreases testosterone production by inhibiting gonadotropin-releasing hormone from stimulating the anterior pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The long-term efficacy of this drug has been demonstrated in clinical studies lasting up to two years with no significant adverse effects on bone mineral density or sexual function.

Purezza: Min. 95%

Ref: 3D-FH138112