CAS 767340-03-4

(2Z)-3-Amino-1-[5,6-diidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-2-buten-1-one

Descrizione:

(2Z)-3-Amino-1-[5,6-diidro-3-(trifluorometil)-1,2,4-triazolo[4,3-a]pirazin-7(8H)-il]-4-(2,4,5-trifluorofenil)-2-buten-1-one è un composto organico complesso caratterizzato dalle sue uniche caratteristiche strutturali, inclusi un nucleo di triazolo-pirazina e molteplici sostituenti trifluorometilici e trifluorofenilici. Questo composto mostra un'attività biologica significativa, spesso indagata per il suo potenziale come agente farmaceutico. La presenza del gruppo amminico suggerisce che potrebbe partecipare a legami idrogeno, influenzando la sua solubilità e reattività. I gruppi trifluorometilici aumentano la lipofilia e possono contribuire alle proprietà farmacocinetiche del composto. Inoltre, il sistema coniugato formato dalla parte di butenone può fornire reattività in varie trasformazioni chimiche. La sua struttura molecolare indica potenziali interazioni con bersagli biologici, rendendolo un argomento di interesse nella chimica medicinale. In generale, questo composto esemplifica l'intricata relazione tra struttura molecolare e attività biologica, evidenziando l'importanza dei composti fluorurati nel design dei farmaci.

Formula: C₁₆H₁₃F₆N₅O

InChI: InChI=1/C16H13F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4-6H,1-3,7,23H2/b9-5-

InChI key: InChIKey=RLSFDUAUKXKPCZ-UITAMQMPSA-N

SMILES: C(F)(F)(F)C=1N2C(CN(C(/C=C(/CC3=C(F)C=C(F)C(F)=C3)\N)=O)CC2)=NN1

Sinonimi:

• (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• (Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one
• 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(2Z)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-
• 2-Buten-1-one, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z)-
• (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• （2Z）-2-amine-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro][1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en (2-4)
• (2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]

Sitagliptin Enamine ((Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one)

CAS: 767340-03-4

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Formula: C₁₆H₁₃F₆N₅O

Colore e forma: Off-White Solid

Peso molecolare: 405.10243

Ref: 45-1A02650

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

Formula: C₁₆H₁₃F₆N₅O

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 405.2977

Ref: IN-DA0036IO

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

Purezza: 95%

Peso molecolare: 405.3g/mol

Ref: 54-PC1004071

Sitagliptin Impurity 34

CAS: 767340-03-4

Formula: C₁₆H₁₃F₆N₅O

Colore e forma: White To Off-White Solid

Peso molecolare: 405.30

Ref: 4Z-S-2011

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

Colore e forma: Neat

Ref: 86-MM3378.20

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifl

Prodotto controllato

CAS: 767340-03-4

Applications Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.
References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006)

Formula: C₁₆H₁₃F₆N₅O

Colore e forma: White

Peso molecolare: 405.30

Ref: TR-O865000

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a drug that has been studied in hemodialysis patients and found to reduce the mutation rate. It is also thought to be beneficial for hematocrit levels and x-ray parameters. The mechanism of action of this drug is not yet fully understood. Low doses are thought to have a protective effect on germ cells, whereas high doses are thought to have an adverse effect on them. Iron supplementation may help with the adverse effects of high doses.

Formula: C₁₆H₁₃F₆N₅O

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 405.3 g/mol

Ref: 3D-FO155533

Sitagliptin Enamine Impurity

CAS: 767340-03-4

Formula: C₁₆H₁₃F₆N₅O

Peso molecolare: 405.30

Ref: ST-EA-CP-S3016

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine

CAS: 767340-03-4

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a useful organic compound for research related to life sciences. The catalog number is T66986 and the CAS number is 767340-03-4.

Formula: C₁₆H₁₃F₆N₅O

Colore e forma: Solid

Peso molecolare: 405.304

Ref: TM-T66986