CAS 7770-78-7

(-)-Arctigenina

Descrizione:

(-)-Arctigenina è un composto lignano che si trova naturalmente, principalmente in varie piante, inclusa la radice di bardana (Arctium lappa). È caratterizzato dalla sua struttura fenolica, che contribuisce alle sue attività biologiche. Il composto presenta una gamma di proprietà farmacologiche, inclusi effetti antinfiammatori, antiossidanti e potenziali effetti anticancro. (-)-Arctigenina è stato studiato per la sua capacità di modulare vari percorsi di segnalazione, che possono influenzare la proliferazione cellulare e l'apoptosi. Inoltre, ha mostrato promesse nella protezione contro le malattie neurodegenerative grazie alle sue proprietà neuroprotettive. La sostanza è tipicamente solubile in solventi organici e ha una solubilità limitata in acqua, il che può influenzare la sua biodisponibilità. La sua formula molecolare riflette un complesso arrangiamento di atomi di carbonio, idrogeno e ossigeno, contribuendo alle sue diverse attività biologiche. In generale, (-)-Arctigenina è di grande interesse nella chimica medicinale e nella farmacologia per le sue potenziali applicazioni terapeutiche.

Formula: C₂₁H₂₄O₆

InChI: InChI=1/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3

InChI key: InChIKey=NQWVSMVXKMHKTF-JKSUJKDBSA-N

SMILES: C([C@@H]1[C@@H](CC2=CC(OC)=C(OC)C=C2)COC1=O)C3=CC(OC)=C(O)C=C3

Sinonimi:

• (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
• (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
• 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-
• 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-
• 4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one
• Arctidine
• (-)-Arctigenin
• (-)-Arctigenin
• Arctigenin
• dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)-
• (3R,4R)-3-(3-Methoxy-4-hydroxybenzyl)-4-(3,4-dimethoxybenzyl)tetrahydrofuran-2-one
• 2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]
• 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl]
• ARCTIGENIN:2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R)
• ARCTIGENIN(P)
• (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]tetrahydrofuran-2-one
• (3R)-3α-(3-Methoxy-4-hydroxybenzyl)-4β-(3,4-dimethoxybenzyl)-4,5-dihydrofuran-2(3H)-one

ARCTIGENIN

CAS: 7770-78-7

Formula: C₂₁H₂₄O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 372.4117

Ref: IN-DA005GJC

Arctigenin

CAS: 7770-78-7

Arctigenin

Purezza: ≥95%

Peso molecolare: 372.41g/mol

Ref: 54-BUP00018

(-)-Arctigenin

CAS: 7770-78-7

Formula: C₂₁H₂₄O₆

Purezza: >95.0%(GC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 372.42

Ref: 3B-A3117

Arctigenin

CAS: 7770-78-7

Arctigenin, naturally occurring in Bardanae fructus, Saussurea medusa, Arctium lappa L., Torreya nucifera and Ipomea cairica, is a phenylpropanoid dibenzylbutyrolactone lignan with antioxidant and anti-inflammatory activities, it can potently inhibit the activity of MKK1 in vitro with the IC(50) value of 1 nM, and inhibit activation of MAP kinases including ERK1/2, p38 kinase and JNK through the inhibition of MKK activities, leading to AP-1 inactivation, which might, at least in part, contribute to the inhibition of TNF-α production, inhibits expression via suppressing JAK-pathway in macrophages.[1,2]

Formula: C₂₁H₂₄O₆

Purezza: 95%~99%

Colore e forma: Powder

Peso molecolare: 372.417

Ref: BP-BP0186

Arctigenin

CAS: 7770-78-7

(-)-Arctigenin ((-)-Arctigenin) is found in burdock.

Formula: C₂₁H₂₄O₆

Purezza: 98% - 99.51%

Colore e forma: Solid

Peso molecolare: 372.41

Ref: TM-T2957

Arctigenin

CAS: 7770-78-7

Formula: C₂₁H₂₄O₆

Peso molecolare: 372.42

Ref: 7W-GY3454

Arctigenin

CAS: 7770-78-7

Lactone

Formula: C₂₁H₂₄O₆

Purezza: ≥ 98.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 372.42

Ref: 5G-80354

Arctigenin

Prodotto controllato

CAS: 7770-78-7

Applications Arctigenin is a plant ligan associated with anticancer and antioxidant properties.
References Heinonen, S., et al.: J. Agric. Food Chem., 49, 3178-3186 (2001); Cai, Y., et al.: Life Sci., 78, 2877-2888 (2006)

Formula: C₂₁H₂₄O₆

Colore e forma: Neat

Peso molecolare: 372.41

Ref: TR-A766580

(-)-Arctigenin

CAS: 7770-78-7

(-)-Arctigenin is a lignan compound, which is naturally derived from certain plant species, primarily found in the seeds of Arctium lappa, commonly known as burdock. The compound exhibits a diverse mode of action, primarily noted for its ability to inhibit the proliferation of cancer cells through apoptosis induction, cell cycle arrest, and modulation of various signaling pathways. Additionally, it exerts antiviral effects by targeting viral replication processes and exhibits anti-inflammatory properties by downregulating pro-inflammatory cytokines.

Formula: C₂₁H₂₄O₆

Purezza: Min. 94.0 Area-%

Peso molecolare: 372.41 g/mol

Ref: 3D-Q-100825

(-)-Arctigenin

CAS: 7770-78-7

(-)-Arctigenin is a natural lignan, which is an active compound isolated from plants such as Arctium lappa (greater burdock) and other members of the Asteraceae family. It acts via several biochemical pathways, notably by inhibiting cellular proliferation and inducing apoptosis in certain cancer cell lines. Additionally, (-)-Arctigenin can modulate immune responses and possesses anti-inflammatory and antiviral properties by interfering with viral replication processes.

Formula: C₂₁H₂₄O₆

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 372.41 g/mol

Ref: 3D-FA41645