CAS 7772-94-3

2-(Acetilammino)-2-desossi-β-D-mannopiranosio

Descrizione:

2-(Acetilammino)-2-desossi-β-D-mannopiranosio, comunemente noto come N-acetilmannosamina, è uno zucchero amminico che svolge un ruolo significativo in vari processi biologici, in particolare nella sintesi di glicoproteine e glicolipidi. Questo composto presenta un gruppo acetilamino nella posizione C-2 dell'anello di manopiranosio, il che contribuisce alle sue proprietà biochimiche. È tipicamente un solido cristallino bianco o bianco sporco che è solubile in acqua, riflettendo la sua natura polare a causa dei gruppi idrossile e amminico. La presenza del gruppo acetilamino ne aumenta la reattività e gli consente di partecipare a varie vie metaboliche, comprese quelle coinvolte nella biosintesi dell'acido sialico. La N-acetilmannosamina è anche importante nei processi di segnalazione e riconoscimento cellulare, rendendola un argomento di interesse nella ricerca relativa alle interazioni cellulari e ai meccanismi delle malattie. Il suo numero CAS, 7772-94-3, è utilizzato per l'identificazione in database chimici e contesti normativi. In generale, questo composto è significativo sia in biochimica che in applicazioni farmaceutiche.

Formula: C₈H₁₅NO₆

InChI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5+,6-,7-,8-/m1/s1

InChI key: InChIKey=OVRNDRQMDRJTHS-OZRXBMAMSA-N

SMILES: N(C(C)=O)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O

Sinonimi:

• 2-(Acetylamino)-2-Deoxyhexopyranose Hydrate
• 2-(Acetylamino)-2-deoxy-β-<span class="text-smallcaps">D</span>-mannopyranose
• 2-(acetylamino)-2-deoxy-alpha-D-gulopyranose
• Mannopyranose, 2-acetamido-2-deoxy-, β-<span class="text-smallcaps">D</span>-
• N-Acetyl-D-mannosamine monohydrate
• β-<span class="text-smallcaps">D</span>-Mannopyranose, 2-(acetylamino)-2-deoxy-
• 2-(Acetylamino)-2-deoxy-β-D-mannopyranose
• β-D-Mannopyranose, 2-(acetylamino)-2-deoxy-
• Mannopyranose, 2-acetamido-2-deoxy-, β-D-

N-Acetylmannosamine

CAS: 7772-94-3

Formula: C₈H₁₅NO₆

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 221.2078

Ref: IN-DA003SOW

N-Acetyl-D-mannosamine

CAS: 7772-94-3

Formula: C₈H₁₅NO₆·xH₂O

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 221.21 (anhydrous)

Ref: 7W-GK3319

2-(Acetamido)-2-deoxy-β-D-mannopyranose

CAS: 7772-94-3

2-(Acetamido)-2-deoxy-β-D-mannopyranose

Purezza: 97% (Monohydrate)

Peso molecolare: 221.21g/mol

Ref: 54-OR8153

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl-D-mannosamine

Colore e forma: White To Off White Powder

Peso molecolare: 239.22g/mol

Ref: 54-BIA1221

Cyclic N-Acetyl-D-mannosamine

CAS: 7772-94-3

Cyclic N-Acetyl-D-mannosamine is used for sialic acid synthesis and as a precursor for biologically active compounds.

Formula: C₈H₁₅NO₆

Purezza: 99.18% - 99.72%

Colore e forma: White Crystal Powder

Peso molecolare: 221.21

Ref: TM-T4725

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Formula: C₈H₁₅NO₆

Purezza: Min. 97.5 Area-%

Peso molecolare: 221.21 g/mol

Ref: 3D-Z-1000

N-Acetyl-D-mannosamine - low endotoxin grade

CAS: 7772-94-3

Please enquire for more information about N-Acetyl-D-mannosamine - low endotoxin grade including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₈H₁₅NO₆

Peso molecolare: 221.21 g/mol

Ref: 3D-Z-1082

N-Acetyl-D-mannosamine

CAS: 7772-94-3

Purezza: 95%

Peso molecolare: 221.21

Ref: 10-F493709

N-Acetyl-D-mannosamine

CAS: 7772-94-3

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. It has been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Formula: C₈H₁₅NO₆

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 221.21 g/mol

Ref: 3D-MA05269