CAS 78113-36-7

Romurtide

Descrizione:

Romurtide, con il numero CAS 78113-36-7, è un peptide sintetico che è stato studiato per le sue potenziali applicazioni terapeutiche, in particolare nel campo dell'immunologia e dell'oncologia. È noto per la sua capacità di stimolare il sistema immunitario, in particolare migliorando l'attività delle cellule T e delle cellule natural killer, che svolgono ruoli cruciali nella difesa del corpo contro tumori e infezioni. Romurtide è spesso classificato come un immunomodulatore ed è stato studiato per i suoi effetti su vari tipi di cancro, così come per il suo potenziale di migliorare le risposte immunitarie nei pazienti sottoposti a chemioterapia. La sostanza viene tipicamente somministrata per iniezione ed è stata valutata in studi clinici per la sua sicurezza e efficacia. Come molti peptidi, la sua stabilità e biodisponibilità possono essere influenzate da fattori come la formulazione e il metodo di somministrazione. In generale, Romurtide rappresenta un'area promettente di ricerca nello sviluppo di strategie immunoterapeutiche.

Formula: C₄₃H₇₈N₆O₁₃

InChI: InChI=1/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59)/t28-,29+,31+,32+,33+,36+,37+,38+,43?/m0/s1

InChI key: InChIKey=IKSJCVFYCIKDTB-GZZWOGMVSA-N

SMILES: [C@H]([C@@H](NC(C)=O)C=O)(O[C@@H](C(N[C@H](C(N[C@H](CCC(N[C@@H](CCCCNC(CCCCCCCCCCCCCCCCC)=O)C(O)=O)=O)C(N)=O)=O)C)=O)C)[C@@H]([C@@H](CO)O)O

Sinonimi:

• (2R)-2-{[(4R)-4-{[(2S)-2-{[(2R)-2-{[(3R,4R,5S,6R)-3-(acetylamino)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoyl]amino}-6-(octadecanoylamino)hexanoic acid (non-preferred name)
• 1: PN: WO2009033811 PAGE: 103 claimed protein
• <span class="text-smallcaps">L</smallcap>-Lysine, N-(N-acetylmuramoyl)-<smallcap>L</smallcap>-alanyl-<smallcap>D</span>-α-glutaminyl-N⁶-(1-oxooctadecyl)-
• <span class="text-smallcaps">L</smallcap>-Lysine, N²-[N²-[N-(N-acetylmuramoyl)-<smallcap>L</smallcap>-alanyl]-<smallcap>D</span>-α-glutaminyl]-N⁶-(1-oxooctadecyl)-
• Ac-Muramyl-Ala-D-Glu(Lys(Stearoyl)-Oh)-Nh2
• Dj 7041
• MDP-Lys(L 18)
• Muroctasin
• Muroctasine
• N-(N-Acetylmuramoyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</smallcap>-α-glutaminyl-N⁶-(1-oxooctadecyl)-<smallcap>L</span>-lysine
• N^α-Acetylmuramoyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</smallcap>-isoglutaminyl-N^ε-stearoyl-<smallcap>L</span>-lysine
• Nopia
• Romurtide
• N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-L-lysine
• L-Lysine, N2-[N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N6-(1-oxooctadecyl)-
• L-Lysine, N-(N-acetylmuramoyl)-L-alanyl-D-α-glutaminyl-N6-(1-oxooctadecyl)-
• Nα-Acetylmuramoyl-L-alanyl-D-isoglutaminyl-Nε-stearoyl-L-lysine
• C13187
• N2-[(N-Acetylmuramoyl)-L-Ala-D-γGln-]-N6-stearoyl-L-Lys-OH
• n(sup2)-((n-acetylmuramoyl)-l-alanyl-d-isoglutaminyl)-n(sup6)-stearoyl-l-ly
• N-acetylmuramyl-ala-D-isoglutaminyl-*N-epsilon-st
• l-lysine,n(sup2),(n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutaminyl
• N^<2>^-[N^<2>^-[N-(N-Acetylmuramoyl)-L-alanyl]-D-α-glutaminyl]-N^<6>^-(1-oxooctadecyl)-L-lysine
• n-acetylmuramyl-ala-d-isoglutaminyl-nε-stearoyl-lys
• Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH
• Ac-MuraMyl-Ala-D-Isogln-Lys(stearoyl)-OH, Muroctasin, RoMurtide, MDP-Lys(L 18)
• N-Acetylmuramyl-alanyl-D-isoglutaminyl-N'-stearoyl-lysine
• Na-Acetylmuramyl-L-alanyl-D-isoglutaminyl-Ne-stearoyl-L-lysine
• )-n(sup6)-(1-oxooctadecyl)-
• N2-[(R)-5-Amino-4-[[N-(N-acetylmuramoyl)-L-alanyl]amino]-1,5-dioxopentyl]-N6-stearoyl-L-lysine
• Muroetasin
• L-Lysine, N-(N-acetylmuramoyl)-L-alanyl-D-a-glutaminyl-N6-(1-oxooctadecyl)- (9CI)
• N-ACETYLMURAMYL-ALA-D-ISOGLUTAMINYL-N-EP SILON-STEA
• Ac-muramyl-A
• Romurtide USP/EP/BP
• AC-MURAMYL-ALA-D-ISOGLN-LYS(STEAROYL)-OH

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH₂

CAS: 78113-36-7

The investigation of the adjuvant activity of this muramyl peptide on humoral and cellular immune responses showed that it augments the mitogenic responses of splenic lymphocytes to phytohemagglutinin and lipopolysaccharide and the formation of antibodies to sheep erythrocytes in mice. In addition, it potentiated polyclonal B cell activation in vivo and in vitro.

Formula: C₄₃H₇₈N₆O₁₃

Purezza: > 98%

Colore e forma: White Powder

Peso molecolare: 887.13

Ref: 01-4015937

Romurtide

CAS: 78113-36-7

Romurtide is a synthetic muramyl dipeptide analog and can be used for the prophylaxis of leukocytopenia during radiation therapy.

Formula: C₄₃H₇₈N₆O₁₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 887.126

Ref: TM-TP2405

Romurtide

CAS: 78113-36-7

Formula: C₄₃H₇₈N₆O₁₃

Purezza: ≥ 98.0%

Colore e forma: White powder

Peso molecolare: 887.11

Ref: 7W-GP1044

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2

CAS: 78113-36-7

Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 is a synthetic peptide that was designed to mimic the sequence of muramyl dipeptide (MDP), which is found in bacterial cell walls. Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 binds to the protein albumin, which is an important component of human blood plasma and has been shown to be elevated in patients with autoimmune diseases. This peptide also inhibits the activity of metal hydroxides, such as aluminum hydroxide and calcium hydroxide, by binding to their surface, reducing their antimicrobial activity. The effect on locomotor activity has not been studied. Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 may have effects on various cells types including macrophages and T

Formula: C₄₃H₇₈N₆O₁₃

Purezza: Min. 95%

Colore e forma: Solid

Peso molecolare: 887.11 g/mol

Ref: 3D-FA110464