CAS 78432-77-6

10-Deacetiltaxolo

Descrizione:

10-Deacetiltaxolo, con il numero CAS 78432-77-6, è un derivato del prodotto naturale taxolo, noto per le sue proprietà anticancro. Questo composto è caratterizzato dall'assenza di un gruppo acetile nella posizione C10, che lo distingue dal taxolo. Presenta una complessa struttura policiclica tipica dei taxani, con un nucleo di taxano che contribuisce alla sua attività biologica. 10-Deacetiltaxolo è principalmente riconosciuto per la sua capacità di stabilizzare i microtubuli, inibendo così la divisione cellulare, che è un meccanismo cruciale nel trattamento del cancro. Il composto è spesso studiato per le sue potenziali applicazioni terapeutiche e può mostrare diversi gradi di citotossicità contro diverse linee cellulari tumorali. Inoltre, la sua solubilità e stabilità nei sistemi biologici possono influenzare la sua efficacia come agente terapeutico. In generale, 10-Deacetiltaxolo rappresenta un composto importante nel campo della chimica medicinale, in particolare nello sviluppo di agenti chemioterapici.

Formula: C₄₅H₄₉NO₁₃

InChI: InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

InChI key: InChIKey=TYLVGQKNNUHXIP-MHHARFCSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Sinonimi:

• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Deacetylpaclitaxel
• 10-Deacetyltaxol
• 10-Deacetyltaxol A
• 10-Desacetylpaclitaxel
• 10-Desacetyltaxol
• 10-O-Deacetyltaxol
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Epi-10-deacetyl paclitaxel
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

Paclitaxel EP Impurity G (10-Desacetyl Paclitaxel)

CAS: 78432-77-6

Formula: C₄₅H₄₉NO₁₃

Colore e forma: Pink Solid

Peso molecolare: 811.88

Ref: 4Z-P-286

10-Deacetyltaxol

CAS: 78432-77-6

Formula: C₄₅H₄₉NO₁₃

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 811.88

Ref: 7W-GY7900

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol

Purezza: ≥90%

Peso molecolare: 811.87g/mol

Ref: 54-BUP00167

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

Formula: C₄₅H₄₉NO₁₃

Purezza: 95%~99%

Peso molecolare: 811.881

Ref: BP-BP0012

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.

Formula: C₄₅H₄₉NO₁₃

Purezza: 94.63% - 99.93%

Colore e forma: Solid

Peso molecolare: 811.87

Ref: TM-T5165

10-Deacetyltaxol

CAS: 78432-77-6

Peso molecolare: 811.881

Ref: 10-F986787

10-Desacetyl Paclitaxel

CAS: 78432-77-6

Impurity Paclitaxel - impurity G
Applications A semi-synthetic precursor of Paclitaxel. Paclitaxel - impurity G.

Formula: C₄₅H₄₉NO₁₃

Colore e forma: White To Off-White

Peso molecolare: 811.87

Ref: TR-D288710

10-Desacetyl paclitaxel

CAS: 78432-77-6

10-Desacetyl paclitaxel is a form of paclitaxel that has been modified chemically. It is soluble in water and can be injected intravenously. 10-Desacetyl paclitaxel is used to treat inflammatory diseases, such as rheumatoid arthritis and psoriasis. This drug binds to the hydroxyl groups on the surface of the bacterial cell wall and prevents the formation of covalent linkages with polysaccharides, which leads to its increased patency in bacterial cells. 10-Desacetyl paclitaxel has also been shown to inhibit the activity of certain enzymes that are involved in synthesis of DNA, RNA, and proteins. This inhibition results in cell death by apoptosis or necrosis. The increase in viability after treatment with 10-desacetyl paclitaxel was observed for both gram-positive bacteria (e.g., Bacillus subtilis) and gram-negative bacteria (e.g., Escher

Formula: C₄₅H₄₉NO₁₃

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 811.87 g/mol

Ref: 3D-FD21126

Paclitaxel EP Impurity G

CAS: 78432-77-6

Formula: C₄₅H₄₉NO₁₃

Peso molecolare: 811.88

Ref: ST-EA-CP-P36007