CAS 789-61-7

2'-Desossi-6-tioguanosina

Descrizione:

2'-Desossi-6-tioguanosina è un analogo di nucleoside che presenta un gruppo tiol nella posizione 6 della base della guanina, sostituendo l'ossigeno tipico presente nei nucleosidi standard. Questa modifica conferisce proprietà biochimiche uniche, rendendolo di interesse in vari campi, tra cui la chimica medicinale e la biologia molecolare. Il composto consiste in uno zucchero desossiribosio legato a una base di guanina modificata, che può partecipare alla sintesi degli acidi nucleici e potenzialmente interferire con i normali processi cellulari. La sua struttura consente di essere incorporato nel DNA, dove può influenzare la replicazione e la trascrizione. 2'-Desossi-6-tioguanosina è stato studiato per le sue potenziali applicazioni terapeutiche, in particolare nel contesto di trattamenti antivirali e anticancro, poiché può imitare i nucleosidi naturali e interrompere la funzione degli acidi nucleici in patogeni o cellule tumorali. Inoltre, il suo unico gruppo tiol può partecipare a reazioni redox, influenzando le vie di segnalazione cellulare. In generale, questo composto rappresenta un'area significativa di ricerca grazie al suo potenziale di modulare i sistemi biologici.

Formula: C₁₀H₁₃N₅O₃S

InChI: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1

InChI key: InChIKey=SCVJRXQHFJXZFZ-KVQBGUIXSA-N

SMILES: S=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1

Sinonimi:

• 2′-Deoxythioguanosine
• Thioguanine deoxyriboside
• Guanosine, 2′-deoxy-6-thio-
• 2′-Deoxy-6-thioguanosine
• 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

Formula: C₁₀H₁₃N₅O₃S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 283.3069

Ref: IN-DA00G38M

2''-Deoxy-6-thioguanosine

CAS: 789-61-7

Ref: 7W-GN2065

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine

Purezza: ≥95%

Peso molecolare: 283.31g/mol

Ref: 54-BUP06562

6-Thio-2'-Deoxyguanosine

CAS: 789-61-7

6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.

Formula: C₁₀H₁₃N₅O₃S

Purezza: 97.52%

Colore e forma: Solid

Peso molecolare: 283.31

Ref: TM-T6746

2′-Deoxy-6-Thio-Guanosine

CAS: 789-61-7

Formula: C₁₀H₁₃N₅O₃S

Peso molecolare: 283.31

Ref: 4Z-G-2462

2'-Deoxy-6-thio Guanosine

Prodotto controllato

CAS: 789-61-7

Applications Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999);

Formula: C₁₀H₁₃N₅O₃S

Colore e forma: Neat

Peso molecolare: 283.31

Ref: TR-D281650

2'-Deoxy-6-thioguanosine

CAS: 789-61-7

2'-Deoxy-6-thioguanosine is a purine nucleoside analog that inhibits the activation of transcription factors such as nuclear factor kappa-B (NF-κB) and activator protein 1 (AP-1). It also inhibits the synthesis of proinflammatory cytokines, such as IL-1β, IL-6, and TNFα. The matrix effect is an important factor in the prevention of tumor progression. 2'-Deoxy-6-thioguanosine has been shown to inhibit cell proliferation and induce apoptosis in squamous cell carcinoma cells by modulating the expression of HLA class II molecules on tumors. It also prevents invasion by blocking matrix metalloproteinase activity. 2'-Deoxy-6-thioguanosine has been found to be effective against bowel diseases such as ulcerative colitis and Crohn's disease, as well as infectious diseases such as HIV/AIDS.

Formula: C₁₀H₁₃N₅O₃S

Purezza: Min. 97 Area-%

Colore e forma: Powder

Peso molecolare: 283.31 g/mol

Ref: 3D-ND08563

2'-Deoxy-6-thioguanosine - Bio-X ™

CAS: 789-61-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₃N₅O₃S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 283.31 g/mol

Ref: 3D-BD300155

6-Thio-2′-deoxyguanosine

CAS: 789-61-7

Purezza: 98%

Peso molecolare: 283.310

Ref: 10-F980551

2'-Deoxy-6-thio Guanosine-13C, 15N2

Prodotto controllato

CAS: 789-61-7

Applications 2'-Deoxy-6-thio Guanosine-13C, 15N2 is labelled 2'-Deoxy-6-thio Guanosine (D281650) which is a Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.
References Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999)

Formula: CC₉H₁₃₁₅N₂N₃O₃S

Colore e forma: Neat

Peso molecolare: 286.286

Ref: TR-D281652