CAS 79350-37-1

Cefixima

Descrizione:

Cefixima è un antibiotico cefalosporinico ad ampio spettro utilizzato principalmente per trattare infezioni batteriche. È efficace contro una varietà di batteri gram-positivi e gram-negativi, rendendolo utile per condizioni come infezioni delle vie respiratorie, infezioni delle vie urinarie e alcuni tipi di gastroenterite. Cefixima agisce inibendo la sintesi della parete cellulare batterica, portando alla lisi cellulare e alla morte. Il composto è tipicamente somministrato per via orale ed è ben assorbito nel tratto gastrointestinale, con la sua biodisponibilità aumentata dall'assunzione di cibo. Cefixima è caratterizzato dalla sua struttura chimica, che include un anello beta-lattamico, una caratteristica chiave delle cefalosporine che è cruciale per la sua attività antibatterica. È generalmente ben tollerato, ma come tutti gli antibiotici, può causare effetti collaterali, inclusi disturbi gastrointestinali e reazioni allergiche in alcune persone. La resistenza a Cefixima può verificarsi, in particolare con l'uso eccessivo o improprio di antibiotici, evidenziando l'importanza di pratiche di prescrizione appropriate. Nel complesso, Cefixima rimane un'opzione preziosa nel trattamento di varie infezioni batteriche.

Formula: C₁₆H₁₅N₅O₇S₂

InChI: InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1

InChI key: InChIKey=OKBVVJOGVLARMR-QSWIMTSFSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OCC(O)=O)/C=3N=C(N)SC3)=O)C2=O)(SCC1C=C)[H]

Sinonimi:

• (-)-Cefixim
• (6R,7R)-7-(2-(2-Amino-4-thiazolyl)gloxylamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7(square)-(Z)-(O-(carboxymethyl)oxime)-trihydrate
• (6R,7R)-7-({(2-amino-1,3-thiazol-4-yl)[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate
• (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, [6R-[6α,7α(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-
• Cefexy
• Cefixime main-ring
• Cefiximine
• Cefixoral
• Cefoceb
• Cefspan
• Ceftas
• Cephoral
• Cl 284635
• Fixitil
• Fk 027
• Fr 17027
• Hifen
• Loprax
• Oroken
• Suprax
• Suprax (antibiotic)
• Taxim-O
• Unixime

Cefixime

CAS: 79350-37-1

Formula: C₁₆H₁₅N₅O₇S₂

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 453.4496

Ref: IN-DA003AX7

Cefixime

CAS: 79350-37-1

Cefixime is a broad-spectrum third-gen cephalosporin antibiotic, stable against beta-lactamases and more effective on gram-negative bacteria.

Formula: C₁₆H₁₅N₅O₇S₂

Purezza: 97.29%

Colore e forma: White To Off White Powder Or Off White Crystal Powder

Peso molecolare: 453.45

Ref: TM-T0932

Cefixime-13C-15N2

CAS: 79350-37-1

Formula: C₁₅₁₃CH₁₅N₃₁₅N₂O₇S₂

Peso molecolare: 456.42

Ref: 4Z-C-912

Cefixime

CAS: 79350-37-1

Cefixime

Purezza: ChP, ≥98%

Peso molecolare: 453.45g/mol

Ref: 54-OR1029839

Cefixime

CAS: 79350-37-1

Cefixime

Purezza: ≥95%

Peso molecolare: 453.45g/mol

Ref: 54-BUP17014

Cefixime

CAS: 79350-37-1

Formula: C₁₆H₁₅N₅O₇S₂

Colore e forma: Off-White Solid

Peso molecolare: 453.44

Ref: 4Z-C-911

Cefixime-13C,15N2

Prodotto controllato

CAS: 79350-37-1

Applications Labelled Cefixime (C242800). Orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Formula: C₁₅₁₃CH₁₅N₃₁₅N₂O₇S₂

Colore e forma: Beige Solid

Peso molecolare: 456.43

Ref: TR-C242802

Cefixime

CAS: 79350-37-1

Stability Hygroscopic
Applications Orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Formula: C₁₆H₁₅N₅O₇S₂

Colore e forma: Off-White To Light Yellow

Peso molecolare: 453.45

Ref: TR-C242800

Cefixime-13C3-15N2

Prodotto controllato

CAS: 79350-37-1

Formula: C₁₃C₃H₁₅N₃N₂O₇S₂

Colore e forma: Neat

Peso molecolare: 607.598

Ref: TR-C242801

Cefixime

CAS: 79350-37-1

Cefixime is a penicillin-binding protein inhibitor that binds to the 50S ribosomal subunit. It is used for the treatment of infectious diseases caused by bacteria. Cefixime has been shown to have an optimum concentration of 2-4 micrograms/mL in human plasma. The oral bioavailability of cefixime is approximately 30% and it has an elimination half-life of 1.5 hours. The drug is metabolized primarily through oxidation by cytochrome P450 enzymes, which are induced by other drugs, such as erythromycin and clarithromycin, or enzyme inducers such as phenobarbital, rifampin, or carbamazepine. Cefixime inhibits bacterial growth through competitive inhibition with penicillin-binding proteins (PBPs), which are required for bacterial cell wall synthesis and protein synthesis.

Formula: C₁₆H₁₅N₅O₇S₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 453.45 g/mol

Ref: 3D-EDA35037