CAS 79548-73-5

Pirlimicina

Descrizione:

Pirlimicina è un antibiotico appartenente alla classe delle lincosamidi, utilizzato principalmente in medicina veterinaria per il trattamento delle infezioni nel bestiame, in particolare la mastite. È efficace contro una gamma di batteri Gram-positivi, comprese alcune ceppi di Staphylococcus e Streptococcus. La struttura chimica di Pirlimicina presenta un nucleo biciclico unico che è caratteristico delle lincosamidi, il che contribuisce al suo meccanismo d'azione inibendo la sintesi proteica batterica. Questa inibizione avviene attraverso il legame con la subunità ribosomiale 50S, bloccando efficacemente la formazione di legami peptidici. Pirlimicina viene tipicamente somministrato tramite infusione intramammaria o iniezione, e la sua farmacocinetica consente una penetrazione efficace nei tessuti, rendendolo adatto per il trattamento di infezioni localizzate. Sebbene sia generalmente ben tollerato, gli effetti collaterali potenziali possono includere disturbi gastrointestinali o reazioni allergiche in alcuni animali. Come con tutti gli antibiotici, un uso responsabile è cruciale per mitigare il rischio di sviluppare resistenza agli antibiotici.

Formula: C₁₇H₃₁ClN₂O₅S

InChI: InChI=1S/C17H31ClN2O5S/c1-4-9-5-6-19-10(7-9)16(24)20-11(8(2)18)15-13(22)12(21)14(23)17(25-15)26-3/h8-15,17,19,21-23H,4-7H2,1-3H3,(H,20,24)/t8-,9+,10-,11+,12-,13+,14+,15+,17+/m0/s1

InChI key: InChIKey=HBJOXQRURQPDEX-MHXMMLMNSA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@H](CC)CCN1)([C@H](C)Cl)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H]

Sinonimi:

• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(4-ethyl-2-piperidinyl)carbonyl]amino]-1-thio-, (2S-cis)-
• <span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-
• L-threo-alpha-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-((((2S,4R)-4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-
• L-threo-alpha-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((4-ethyl-2-piperidinyl)carbonyl)amino)-1-thio-, (2S-cis)-
• Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-<span class="text-smallcaps">L</smallcap>-threo-α-<smallcap>D</span>-galacto-octopyranoside
• Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside
• Pirlimycina
• Pirlimycina [INN-Spanish]
• Pirlimycine
• Pirlimycine [INN-French]
• Pirlimycinum
• Pirlimycinum [INN-Latin]
• Unii-Lm19Jt6G5K
• methyl 7-chloro-6,7,8-trideoxy-6-({[(2S,4R)-4-ethylpiperidin-2-yl]carbonyl}amino)-1-thio-L-threo-alpha-D-galacto-octopyranoside
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-
• L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(4-ethyl-2-piperidinyl)carbonyl]amino]-1-thio-, (2S-cis)-

Pirlimycin Hydrochloride (Mixture of Diastereomers)

Prodotto controllato

CAS: 78822-40-9, 79548-73-5

Stability Hygroscopic
Applications Pirlimycin Hydrochloride (Mixture of Diastereomers) is a semi-synthetic lincosaminide antibiotic; structural analog of Clindamycin. Antibacterial.
References Ahonkhai, V.I., et al.: Antimicrob. Agents Chemother., 21, 902 (1982); Qadri, S.M.H., et al.: J. Antibiot., 36, 42 (1983); Birkenmeyer, R.D., et al.: J. Med. Chem., 27, 216 (1984);

Formula: C₁₇H₃₁ClN₂O₅S·ClH

Colore e forma: White To Off-White

Peso molecolare: 447.42

Ref: TR-P509300

Pirlimycin

CAS: 79548-73-5

Pirlimycin is a glycol ester, glycol ether and a member of the antimicrobial agents that inhibits bacterial growth. It has been shown to be effective against streptococcus species and viruses, as well as human serum and fat. Pirlimycin inhibits the synthesis of proteins by binding to the 50S ribosomal subunit in bacteria, leading to cell death. It is also active against Streptococcus pneumoniae and Streptococcus pyogenes (viridans group). The analytical method for pirlimycin is found to be sensitive, simple, accurate and precise. This assay can detect pirlimycin at levels as low as 0.1 ppm in biological samples such as human serum or fatty acid.

Formula: C₁₇H₃₁ClN₂O₅S

Purezza: Min. 95%

Peso molecolare: 411 g/mol

Ref: 3D-EDA54873