CAS 79794-75-5

Loratadina

Descrizione:

Loratadina è un antistaminico di seconda generazione comunemente usato per alleviare i sintomi allergici come naso che cola, starnuti e occhi pruriginosi. È caratterizzato dal suo antagonismo selettivo dei recettori H1 periferici, che aiuta a minimizzare gli effetti collaterali comuni associati agli antistaminici di prima generazione, come la sedazione. Loratadina è una polvere cristallina bianca o quasi bianca che è praticamente insolubile in acqua ma solubile in solventi organici come etanolo e metanolo. La sua formula chimica è C22H23ClN2O2 e ha un peso molecolare di circa 382,88 g/mol. Loratadina viene spesso somministrato per via orale e ha una lunga durata d'azione, consentendo una somministrazione una volta al giorno. Viene metabolizzato nel fegato nel suo metabolita attivo, desLoratadina, che contribuisce ai suoi effetti antistaminici. A causa della sua bassa penetrazione della barriera ematoencefalica, Loratadina è meno probabile che causi sonnolenza rispetto agli antistaminici più vecchi, rendendolo una scelta preferita per le persone che necessitano di sollievo dai sintomi allergici senza sedazione.

Formula: C₂₂H₂₃ClN₂O₂

InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key: InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(OCC)=O)CC4)=CC1

Sinonimi:

• 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
• 11H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 1-piperidinecarboxylic acid deriv.
• 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
• Alavert
• Anhissen
• Bonalerg
• Civeran
• Claratyne
• Claritin
• Claritine
• Clarityn
• Clarityne
• Clarotadin
• Cronopen
• Erolin
• Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
• Flonidan
• Fristamin
• Histaloran
• Klarifer
• Klaritin
• Lertamine
• Lisino
• Lomilan
• Loracert
• Loradex
• Loranox
• Lorastine
• Loratidine
• Loratyne
• Lorfast
• Lowadina
• Optimin
• Polaratyne
• Pylor
• Restamine
• Sch 29851
• Sensibit
• Sohotin
• Symphoral
• Tadine
• Velodan
• Zeos

Desloratadine EP Impurity C

CAS: 79794-75-5

Formula: C₂₂H₂₃ClN₂O₂

Peso molecolare: 382.88

Ref: ST-EA-CP-D15003

Loratadine - Bio-X ™

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₂₃ClN₂O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 382.88 g/mol

Ref: 3D-BL164637

Loratadine

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.

Formula: C₂₂H₂₃ClN₂O₂

Purezza: 98.5 To 101.0%

Colore e forma: Powder

Peso molecolare: 382.88 g/mol

Ref: 3D-FL24933

11-(N-Hydroxy) Loratadine 1-Oxide

Prodotto controllato

CAS: 79794-75-5

Formula: C₁₉H₁₉ClN₂O₂

Colore e forma: Neat

Peso molecolare: 342.819

Ref: TR-H947746