CAS 79952-44-6

Epilovastatina

Descrizione:

Epilovastatina, con il numero CAS 79952-44-6, è un composto sintetico che appartiene alla classe delle statine, utilizzate principalmente per le loro proprietà di riduzione del colesterolo. Funziona inibendo l'enzima HMG-CoA reduttasi, un attore chiave nella biosintesi del colesterolo nel fegato. Questa azione aiuta a ridurre i livelli di lipoproteine a bassa densità (LDL) e trigliceridi, mentre potenzialmente aumenta il colesterolo delle lipoproteine ad alta densità (HDL). Epilovastatina è caratterizzato dalla sua specifica struttura chimica, che include un anello di lattone e vari gruppi funzionali che contribuiscono alla sua attività biologica. Viene tipicamente somministrato per via orale ed è stato studiato per la sua efficacia nella gestione dell'iperlipidemia e nella riduzione del rischio cardiovascolare. Come con altre statine, gli effetti collaterali potenziali possono includere dolore muscolare, alterazioni degli enzimi epatici e disturbi gastrointestinali. La sua farmacocinetica, inclusi assorbimento, metabolismo ed escrezione, è importante per determinare i regimi di dosaggio e comprendere le sue interazioni con altri farmaci.

Formula: C₂₄H₃₆O₅

InChI: InChI=1/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14?,15?,16-,18+,19+,20-,21?,23-/m0/s1

InChI key: InChIKey=PCZOHLXUXFIOCF-YPQFMRJXSA-N

SMILES: O(C([C@@H](CC)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Sinonimi:

• Epilovastatin
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2R)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(S*),3α,7β,8β(2S*,4S*),8aβ]]-
• Lovastatin epi-Isomer
• Simvastatin EP Impurity F/ Simvastatin Related Compound F (epi-Lovastatin/ Lovastatin epimer)
• Epilovastatin, 10 - 15% isoMers
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate
• Epi Lovastatin
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-H
• Simvastatin Impurity 6（EP-F）
• (R)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Simvastatin EP Impurity F (epi-Lovastatin)
• Epilovastatin, 95%, 10 - 15% isomers
• (2R)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
• Simvastatin EP Impurity
• Simvastatin EP Impurity F (epi-Lovastatin)/(2R)-2-Methylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl
• Simvastatin Impurity 6(Simvastatin EP Impurity F)

Epi Lovastatin ((1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate)

CAS: 79952-44-6

Lactones, nesoi

Formula: C₂₄H₃₆O₅

Colore e forma: White Powder

Peso molecolare: 404.25627

Ref: 45-1A10320

Simvastatin EP Impurity F (epi-Lovastatin)

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 404.55

Ref: 4Z-S-128

(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-Methylbutanoate (Epilovastatin)

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Colore e forma: Neat

Peso molecolare: 404.54

Ref: 86-MM0158.06

Epi Lovastatin

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Peso molecolare: 404.5

Ref: ST-EA-CP-L76020

Simvastatin EP Impurity F

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Peso molecolare: 404.55

Ref: ST-EA-CP-S4006

Epi Lovastatin

Prodotto controllato

CAS: 79952-44-6

Impurity Simvastatin EP Impurity F
Applications Epi Lovastatin (Simvastatin EP Impurity F) is a Lovastatin impurity; an antihypercholesterolemic compound.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986),

Formula: C₂₄H₃₆O₅

Colore e forma: Neat

Peso molecolare: 404.54

Ref: TR-E588530

Epi lovastatin

CAS: 79952-44-6

Lovastatin is a cholesterol-lowering drug that acts by inhibiting the enzyme HMG-CoA reductase. It is also used to prevent organ rejection after a liver transplant, and has been shown to have anti-aging effects. Lovastatin has been shown to reduce serum cholesterol levels, which may be due to its ability to inhibit cellular proliferation in rat hepatocytes. This drug has been shown to have an effect on DNA damage and post-translational modification of proteins, as well as on health care foods. Lovastatin is a member of the statins family of drugs, which are all natural products isolated from fungi or bacteria. The active form of lovastatin is made in the laboratory by chemical synthesis, using recombinant DNA technology. The recombinant gene encoding lovastatin was cloned into an expression vector and expressed in Escherichia coli cells (E.M.).

Formula: C₂₄H₃₆O₅

Purezza: Min. 95%

Peso molecolare: 404.54 g/mol

Ref: 3D-IE22709