CAS 811803-05-1

N-[4-(1-Cianociclopentil)fenile]-2-[(4-piridinilmetil)ammino]-3-piridinacarbossamide

Descrizione:

N-[4-(1-Cianociclopentil)fenile]-2-[(4-piridinilmetil)ammino]-3-piridinacarbossamide, con numero CAS 811803-05-1, è un composto organico sintetico caratterizzato dalla sua complessa struttura molecolare, che include più anelli aromatici e gruppi funzionali. Questo composto presenta uno scheletro di piridina carbossamide, noto per la sua potenziale attività biologica, in particolare in chimica medicinale. La presenza di un gruppo cianociclopentilico e di un sostituente amino piridinilmetilico suggerisce che potrebbe interagire con vari bersagli biologici, influenzando possibilmente vie correlate al cancro o ad altre malattie. La sua solubilità, stabilità e reattività dipenderebbero dalle condizioni specifiche, come pH e solvente, a causa della presenza di gruppi funzionali polari. Inoltre, il peso molecolare del composto, il punto di fusione e le proprietà spettroscopiche (come NMR e IR) fornirebbero ulteriori informazioni sulle sue caratteristiche e potenziali applicazioni nello sviluppo di farmaci o come strumento di ricerca in biochimica. In generale, questo composto rappresenta una classe di molecole che potrebbe essere di interesse nella ricerca farmaceutica.

Formula: C₂₄H₂₃N₅O

InChI: InChI=1S/C24H23N5O/c25-17-24(11-1-2-12-24)19-5-7-20(8-6-19)29-23(30)21-4-3-13-27-22(21)28-16-18-9-14-26-15-10-18/h3-10,13-15H,1-2,11-12,16H2,(H,27,28)(H,29,30)

InChI key: InChIKey=WPEWQEMJFLWMLV-UHFFFAOYSA-N

SMILES: C(#N)C1(CCCC1)C2=CC=C(NC(=O)C3=C(NCC=4C=CN=CC4)N=CC=C3)C=C2

Sinonimi:

• 3-Pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-
• Apatinib
• Apatinib (YN968D1)
• Apatinib mesylate
• Aptinib
• N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
• N-[4-(1-cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide
• Rivoceranib
• Yn 968D1
• N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]pyridine-3-carboxamide

Apatinib

CAS: 811803-05-1

Formula: C₂₄H₂₃N₅O

Peso molecolare: 397.48

Ref: 4Z-A-367001

N-(4-(1-Cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

CAS: 811803-05-1

N-(4-(1-Cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide

Purezza: 99%

Peso molecolare: 397.48g/mol

Ref: 54-OR1066769

Apatinib

Prodotto controllato

CAS: 811803-05-1

Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₂₄H₂₃N₅O·CH₄O₃S

Colore e forma: Neat

Peso molecolare: 493.58

Ref: TR-A726150

Apatinib-d8

Prodotto controllato

CAS: 811803-05-1

Applications Apatinib-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Formula: C₂₄H₁₅D₈N₅O

Colore e forma: Neat

Peso molecolare: 405.53

Ref: TR-A726153

Apatinib

CAS: 811803-05-1

Apatinib, also known as rivoceranib, is an inhibitor of the vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase. Apatinib targets VEGFR2 with its action and has proven to have strong anti-tumor effects in human cancers. In studies in mice, apatinib acted as an Inhibitor of VEGFR2 and played an antiangiogenic effect. Apatinib has been suggested for the treatment of ischemia-induced proliferative retinopathy and neovascular age-related macular degeneration.

Formula: C₂₄H₂₃N₅O

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 397.47 g/mol

Ref: 3D-BA175030