CAS 817204-32-3

Citosina, N-benzoil-2'-desossi-2'-fluoro-2'-metil-, 3',5'-dibenzoato, (2'R)-

Descrizione:

Citosina, N-benzoil-2'-desossi-2'-fluoro-2'-metil-, 3',5'-dibenzoato, (2'R)- è un derivato di nucleoside sintetico caratterizzato dalla presenza di un gruppo benzilico e due funzionalità di estere benzoato. Questo composto presenta uno zucchero ribosio modificato, specificamente una configurazione di 2′-desossi-2′-fluoro-2′-metile, che ne migliora la stabilità e la bioattività rispetto ai nucleosidi naturali. La stereochimica (2′R) indica un'assegnazione spaziale specifica dei sostituenti attorno alla parte zuccherina, che è cruciale per la sua interazione con obiettivi biologici. La presenza di fluoro nella parte zuccherina può influenzare le proprietà farmacocinetiche del composto, migliorando potenzialmente la sua resistenza alle nucleasi. Questo composto può presentare proprietà antivirali o anticancro, rendendolo di interesse nella chimica medicinale e nello sviluppo di farmaci. Le sue caratteristiche strutturali uniche contribuiscono alle sue potenziali applicazioni in contesti terapeutici, in particolare nella progettazione di analoghi di nucleosidi per il trattamento di varie malattie.

Formula: C₃₁H₂₆FN₃O₇

InChI: InChI=1S/C31H26FN3O7/c1-31(32)25(42-28(38)22-15-9-4-10-16-22)23(19-40-27(37)21-13-7-3-8-14-21)41-29(31)35-18-17-24(34-30(35)39)33-26(36)20-11-5-2-6-12-20/h2-18,23,25,29H,19H2,1H3,(H,33,34,36,39)/t23-,25-,29-,31-/m1/s1

InChI key: InChIKey=MXEQSUUFNWPUJH-RDWHIKKYSA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](COC(=O)C2=CC=CC=C2)[C@H]1OC(=O)C3=CC=CC=C3)N4C(=O)N=C(NC(=O)C5=CC=CC=C5)C=C4

Sinonimi:

• ((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate
• (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• (2R,3R,4R,5R)-5-4-benzamide-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• 2'-Deoxy-2'-Fluoro-2'-Methyl-N-(Phenylcarbonyl) Cytidine
• 3',5'-O-4-Tribenzoyl-2'-deoxy-2'-fluoro-2'-C-methylcytidine
• Cytidine, N-benzoyl-2′-deoxy-2′-fluoro-2′-methyl-, 3′,5′-dibenzoate, (2′R)-
• N-benzoyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-2-methylcytidine
• PSI-6130 derivative
• Sofosbuvir N-3
• [(2R,3R,4R,5R)-5-(4-benzamido-2-oxo-1,2-dihydropyrimidin-1-yl)-3-(benzoyloxy)-4-fluoro-4-methyloxolan-2-yl]methyl benzoate
• Cytidine,N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-,3',5'-dibenzoate,(2'R)
• Cytidine, N-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-3',5'-Dibenzoate, (2'R)-
• Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, 3',5'-dibenzoate, (2'R)
• Sofosbuvir Intermediates1
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d
• Sofibute 12
• 2'-Defluro-2'-methylene Sofosbuvir
• Sofosbuvir INT 2
• Sofosbuvir Tri benzoyl fluoro cytidine
• N4,3',5'-tri-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-Methylcytidine
• SF-3
• R)-N-benzoyl-2&rsquo
• PSI-6130 derivative ISO 9001：2015 REACH
• Sofosbuvir int. N-3
• -dibenzoateCytidine
• Sofosbuvir Intermediate 2
• InterMediate of Sofosbuir
• (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)
• (2'R)-N-Bz-2'-deoxy-2'-F-2'-Methylcytidine 3',5'-dibenzoate
• -methyl-3&rsquo
• N-BENZOYL-2'-DEOXY-2'-FLUORO-2METHYL-3'5'-DIBENZOATE(2R)
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methyl-3',5'-dibenzoate Cytidine
• 2'-Deoxy-2'-fluoro-2'- Methyl-N-(phenylcarbonyl) cytidine　(N-3)
• Sofosbuvir Impurity 69
• (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• Sofosbuvir imp-5

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate,(2'R)-

CAS: 817204-32-3

Formula: C₃₁H₂₆FN₃O₇

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 571.5524

Ref: IN-DA00ID7G

Sofosbuvir Impurity 56

CAS: 817204-32-3

Formula: C₃₁H₂₆FN₃O₇

Colore e forma: White To Off-White Solid

Peso molecolare: 571.56

Ref: 4Z-S-055063

(2R,3R,4R,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-YL)-2-((Benzoyloxy)Methyl)-4-Fluoro-4-Methyltetrahydrofuran-3-YL Benzoate

CAS: 817204-32-3

(2R,3R,4R,5R)-5-(4-Benzamido-2-Oxopyrimidin-1(2H)-YL)-2-((Benzoyloxy)Methyl)-4-Fluoro-4-Methyltetrahydrofuran-3-YL Benzoate

Purezza: 98%

Peso molecolare: 571.55g/mol

Ref: 54-PC104929

(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

CAS: 817204-32-3

Purezza: 97%

Peso molecolare: 571.5609741210938

Ref: 10-F790039

Sofosbuvir Impurity 5

CAS: 817204-32-3

Formula: C₃₁H₂₆FN₃O₇

Peso molecolare: 571.6

Ref: ST-EA-CP-S45027

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d

CAS: 817204-32-3

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diphosphate (2'R)-N-benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-diphosphate) is a modified nucleoside that is an antiviral, anticancer, and activator of DNA synthesis. It has been shown to be the first synthetic nucleotide analogue to have significant activity against HIV in vitro. The synthesis of this compound starts with the diphosphate or monophosphate form of cytidine. The phosphate group is removed and replaced with a 2'R benzoyl group. This process is followed by fluorination and methylation steps. Finally, the 5' hydroxyl group is cleaved to give 2'R -N benzoyl 2'-deoxy-2'-fluoro-2'-

Formula: C₃₁H₂₆FN₃O₇

Purezza: Min. 95%

Peso molecolare: 571.55 g/mol

Ref: 3D-NB98842