CAS 82-08-6

Rottlerin

Descrizione:

Rottlerin, con il numero CAS 82-08-6, è un composto che si verifica naturalmente ed è derivato dalla pianta Mallotus philippinensis. È classificato come un flavonoide ed è noto per il suo distintivo colore giallo. Rottlerin mostra una gamma di attività biologiche, comprese proprietà anti-infiammatorie, antiossidanti e potenziali anticancerogene. Il suo meccanismo d'azione è attribuito principalmente alla sua capacità di inibire la proteina chinasi C (PKC), che gioca un ruolo cruciale in vari processi cellulari, inclusi la crescita e la differenziazione cellulare. Inoltre, Rottlerin è stato studiato per i suoi effetti su varie vie di segnalazione, rendendolo un argomento di interesse nella ricerca farmacologica. Il composto è solubile in solventi organici, ma ha una solubilità limitata in acqua, il che può influenzare la sua biodisponibilità e le applicazioni terapeutiche. A causa dei suoi diversi effetti biologici, Rottlerin è in fase di esplorazione per un potenziale utilizzo nel trattamento di varie malattie, sebbene siano necessarie ulteriori ricerche per comprendere appieno la sua efficacia e sicurezza in contesti clinici.

Formula: C₃₀H₂₈O₈

InChI: InChI=1/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+

InChI key: InChIKey=DEZFNHCVIZBHBI-ZHACJKMWSA-N

SMILES: C(/C=C/C1=CC=CC=C1)(=O)C2=C3C(=C(O)C(CC4=C(O)C(C(C)=O)=C(O)C(C)=C4O)=C2O)C=CC(C)(C)O3

Sinonimi:

• (2E)-1-[6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-phenylprop-2-en-1-one
• (2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
• 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)-
• 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (E)-
• Acetophenone, 3'-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl)-2',4',6'-trihydroxy-5'-methyl-
• Acetophenone, 3′-[(8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2′,4′,6′-trihydroxy-5′-methyl-
• Brn 0070757
• Kamalin
• Mallotoxin
• Nsc 56346
• Nsc 94525
• PKC-δ/PKC-θ inhibitor
• Rottlerin
• (E)-1-(6-((3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl)-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one
• 5-18-05-00695 (Beilstein Handbook Reference)
• 3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE
• 4’,6’-trihydroxy-5’-methyl-methyl)-2
• acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl)
• 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 516.5385

Ref: IN-DA00G2JN

Rottlerin

CAS: 82-08-6

Rottlerin

Purezza: ≥95%

Peso molecolare: 516.54g/mol

Ref: 54-BUP06758

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Purezza: >95.0%(HPLC)(qNMR)

Colore e forma: Light yellow to Brown powder to crystal

Peso molecolare: 516.55

Ref: 3B-R0266

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Peso molecolare: 516.54

Ref: 7W-GL6758

Rottlerin

CAS: 82-08-6

Formula: C₃₀H₂₈O₈

Peso molecolare: 516.55

Ref: 4Z-R-127001

Rottlerin

CAS: 82-08-6

Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.

Formula: C₃₀H₂₈O₈

Purezza: 97.41% - 99.44%

Colore e forma: Orange To Brown Powder

Peso molecolare: 516.54

Ref: TM-T16791

Rottlerin

Prodotto controllato

CAS: 82-08-6

Applications Rottlerin is a human ether-a-go-go-related gene (hERG) potassium channel activator.
References Zeng, H., et al.: J. Pharmacol. Exp. Ther., 319, 957 (2006)

Formula: C₃₀H₂₈O₈

Colore e forma: Neat

Peso molecolare: 516.54

Ref: TR-R700740

Rottlerin

CAS: 82-08-6

Rottlerin is a polyphenolic compound, which is a natural product derived from the plant species Mallotus philippensis. It is primarily isolated from the fruits or glands of this plant. Rottlerin operates as a selective inhibitor, notably targeting specific protein kinases such as PKC-delta (Protein Kinase C delta). It also affects various other cellular processes and pathways, offering a diverse range of biological effects.

Formula: C₃₀H₂₈O₈

Purezza: Min. 95 Area-%

Colore e forma: Orange Powder

Peso molecolare: 516.54 g/mol

Ref: 3D-FR29637

Rottlerin

CAS: 82-08-6

M02456 - Rottlerin

Formula: C₃₀H₂₈O₈

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 516.546

Ref: 10-M02456