CAS 82159-09-9
:Epalrestat
Descrizione:
Epalrestat è un composto farmaceutico utilizzato principalmente come inibitore dell'aldose reduttasi, che gioca un ruolo significativo nella gestione delle complicanze diabetiche, in particolare nella neuropatia diabetica. Il suo meccanismo d'azione implica l'inibizione dell'enzima aldose reduttasi, responsabile della conversione del glucosio in sorbitolo, riducendo così l'accumulo di sorbitolo e prevenendo lo stress osmotico e ossidativo nei tessuti nervosi. Epalrestat è caratterizzato dalla sua relativamente bassa solubilità in acqua, il che può influenzare la sua biodisponibilità. Il composto viene tipicamente somministrato per via orale ed è stato studiato per il suo potenziale di migliorare la funzione nervosa e alleviare i sintomi associati alla neuropatia diabetica. Inoltre, ha un profilo di sicurezza favorevole, con effetti collaterali generalmente lievi e gestibili. L'efficacia e la sicurezza di Epalrestat sono state valutate in vari studi clinici, contribuendo alla sua accettazione in alcune regioni per il trattamento delle complicanze diabetiche. In generale, Epalrestat rappresenta un approccio mirato nella gestione del diabete, concentrandosi sulla mitigazione degli effetti a lungo termine dell'iperglicemia sulla salute nervosa.
Formula:C15H13NO3S2
InChI:InChI=1/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8+
InChI key:InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES:C(\C(=C\C1=CC=CC=C1)\C)=C\2/C(=O)N(CC(O)=O)C(=S)S2
Sinonimi:- (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid
- 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
- 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-
- 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,E)-
- 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-
- 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-
- 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid
- Eabeth
- Epalrestat [INN]
- Epalrestatum
- Epalrestatum [Latin]
- Kinedak
- Ono 2235
- Sorbistat
- Unii-424Dv0807X
- {(5E)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
- {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
- (E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid
- Epalresta
- Quinedac
- 2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID
- e)-(e
- 5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet
- Epatrestat
- EPALRESTAT(KINEDAK)
- 5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)
- (e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
- EPALRESTAT
- Epatat
- [5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid
- OTAVA-BB BB7211260020
- 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo
- 2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID
- He IpaneMa Division
- Vedi altri sinonimi
Ordinare per
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12 prodotti.
2-[(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
CAS:Formula:C15H13NO3S2Purezza:95%Colore e forma:SolidPeso molecolare:319.3986Epalrestat
CAS:<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>Formula:C15H13NO3S2Purezza:99.2% - 99.54%Colore e forma:Deep Red Acicular CrystalPeso molecolare:319.4Epalrestat
CAS:Formula:C15H13NO3S2Purezza:>98.0%(T)(HPLC)Colore e forma:Light yellow to Amber to Dark green powder to crystalPeso molecolare:319.39Epalrestat
CAS:Prodotto controllato<p>Applications An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.<br>References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985),<br></p>Formula:C15H13NO3S2Colore e forma:NeatPeso molecolare:319.40Epalrestat - Bio-X ™
CAS:<p>Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.</p>Formula:C15H13NO3S2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:319.4 g/molEpalrestat
CAS:<p>Aldose reductase inhibitor</p>Formula:C15H13NO3S2Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:319.4 g/molEpalrestat-d5
CAS:Prodotto controllato<p>Applications Epalrestat-d5 is the labeled analogue of Epalrestat (E565300), an aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.<br>References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983); Kikkawa, R., et al.: Diabetologia, 24, 290 (1983); Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985)<br></p>Formula:C15H8D5NO3S2Colore e forma:NeatPeso molecolare:324.43
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