CAS 82752-99-6

Cloridrato di nefazodone

Descrizione:

Cloridrato di nefazodone è un composto farmaceutico utilizzato principalmente come antidepressivo. Appartiene alla classe di farmaci noti come antagonisti dei recettori della serotonina e inibitori della ricaptazione (SARIs). La struttura chimica della nefazodone presenta un complesso arrangiamento che include un moiety fenilpiperazina, contribuendo alla sua attività farmacologica. Come sale cloridrato, è tipicamente presentato come una polvere cristallina bianca o bianco sporco, solubile in acqua e con stabilità moderata in condizioni standard. La nefazodone agisce modulando i livelli di serotonina nel cervello, alleviando così i sintomi di depressione e ansia. È nota per il suo profilo di effetti collaterali relativamente favorevole rispetto ad altri antidepressivi, sebbene possa comunque causare sonnolenza, vertigini e potenziale tossicità epatica in alcuni pazienti. A causa del suo meccanismo d'azione unico, la nefazodone viene talvolta prescritta quando altri antidepressivi sono inefficaci o mal tollerati. Tuttavia, il suo uso è diminuito negli ultimi anni, in parte a causa di preoccupazioni sulla sicurezza epatica e della disponibilità di antidepressivi più recenti con profili di sicurezza migliorati.

Formula: C₂₅H₃₂ClN₅O₂·ClH

InChI: InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key: InChIKey=DYCKFEBIOUQECE-UHFFFAOYSA-N

SMILES: C(COC1=CC=CC=C1)N2C(CC)=NN(CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)C2=O.Cl

Sinonimi:

• 1-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride
• 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride (1:1)
• 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, hydrochloride (1:1)
• 3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
• Bmy 13754
• Bmy 13754-1
• Dutonin
• Mj 13754-1
• Nefazodone Hydrochloride
• Serazone
• Serzone

Nefazodone hydrochloride, 98+%

CAS: 82752-99-6

An antidepressant acts by modifying serotonin transmission. Mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy b

Formula: C₂₅H₃₂ClN₅O₂•HCl

Purezza: 98+%

Peso molecolare: 506.47

Ref: 02-J62793

Nefazodone Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 82752-99-6

Colore e forma: Single Solution

Ref: 61-AMP0591.00-01

Nefazodone Hydrochloride

CAS: 82752-99-6

Colore e forma: White Solid

Ref: 61-FOR0591.00

Nefazodone Hydrochloride

CAS: 82752-99-6

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₂₅H₃₂ClN₅O₂·HCl

Colore e forma: White Powder

Peso molecolare: 469.22445

Ref: 45-1457902

1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride

CAS: 82752-99-6

Formula: C₂₅H₃₃Cl₂N₅O₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 506.4678

Ref: IN-DA00582N

Nefazodone hydrochloride

CAS: 82752-99-6

Formula: C₂₅H₃₂ClN₅O₂HCl

Peso molecolare: 506.47

Ref: 7W-GP2852

Nefazodone HCl

CAS: 82752-99-6

Formula: C₂₅H₃₂ClN₅O₂·HCl

Colore e forma: White To Off-White Solid

Peso molecolare: 506.48

Ref: 4Z-N-031

Nefazodone hydrochloride

CAS: 82752-99-6

Nefazodone hydrochloride

Purezza: ≥98%

Peso molecolare: 506.47g/mol

Ref: 54-BUP13482

Nefazodone Hydrochloride

CAS: 82752-99-6

Nefazodone Hydrochloride

Purezza: >98.0%

Peso molecolare: 506.47g/mol

Ref: 54-OR1023368

Nefazodone Hydrochloride

Prodotto controllato

CAS: 82752-99-6

Formula: C₂₅H₃₂ClN₅O₂·ClH

Colore e forma: Neat

Peso molecolare: 506.47

Ref: 86-MM0591.00

Nefazodone hydrochloride

CAS: 82752-99-6

Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.

Formula: C₂₅H₃₃Cl₂N₅O₂

Purezza: 99% - 99.86%

Colore e forma: White Solid

Peso molecolare: 506.47

Ref: TM-T3275

Nefazodone-d5 HCl

CAS: 82752-99-6

Formula: C₂₅H₂₇D₅ClN₅O₂·HCl

Peso molecolare: 511.51

Ref: 4Z-N-032

Nefazodone Hydrochloride

Prodotto controllato

CAS: 82752-99-6

Applications A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000);

Formula: C₂₅H₃₂ClN₅O₂·ClH

Colore e forma: Neat

Peso molecolare: 506.47

Ref: TR-N389100

Nefazodone HCl - Bio-X ™

Prodotto controllato

CAS: 82752-99-6

Nefazodone is an anti-depressant that belongs to the group of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used for the treatment of depression. Nefazodone binds to 5-HT2a receptors, which are in the central nervous system, and inhibit the release of neurotransmitters such as dopamine, norepinephrine, and serotonin. As a result, this leads to an increase in levels of these neurotransmitters in the brain. Nefazodone has also been shown to have beneficial effects on brain functions such as memory retrieval and mood control.

Formula: C₂₅H₃₃Cl₂N₅O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 506.47 g/mol

Ref: 3D-BN164641

Nefazodone Hydrochloride

CAS: 82752-99-6, 83366-66-9

Formula: C₂₅H₃₂ClN₅O₂·HCl

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 506.47

Ref: 3B-N1030

Nefazodone-d6 Dihydrochloride

Prodotto controllato

CAS: 1330236-06-0, 82752-99-6

Applications Labelled Nefazodone (N389100). A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
References Eison, A.S., et al.: Psychopharmacol. Bull., 26, 311 (1990), Keller, M.B., et al.: N. Engl. J. Med., 342, 1462 (2000)

Formula: C₂₅H₂₆D₆ClN₅O₂·2HCl

Colore e forma: Neat

Peso molecolare: 476.0523646

Ref: TR-N389102

Nefazodone hydrochloride

Prodotto controllato

CAS: 82752-99-6

Antagonist of 5-HT2A serotonin, α2-adrenergic and dopamine (D2) receptors

Formula: C₂₅H₃₃Cl₂N₅O₂

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 506.47 g/mol

Ref: 3D-FN26173