CAS 83150-76-9

Acetato di octreotide

Descrizione:

Acetato di octreotide è un octapeptide sintetico che imita l'ormone naturale somatostatina, che gioca un ruolo cruciale nella regolazione di vari processi fisiologici, inclusa la secrezione ormonale e la funzione gastrointestinale. È utilizzato principalmente nel campo medico per trattare condizioni come l'acromegalia, alcuni tipi di tumori neuroendocrini e la diarrea severa associata alla sindrome carcinoide. La sostanza è caratterizzata dalla sua capacità di inibire il rilascio dell'ormone della crescita e di altri ormoni, aiutando così a gestire i sintomi legati alla sovrapproduzione ormonale. Acetato di octreotide viene tipicamente somministrato tramite iniezione sottocutanea o intramuscolare e ha una vita media più lunga rispetto alla somatostatina, consentendo una somministrazione meno frequente. La sua struttura chimica include una configurazione ciclica che ne migliora stabilità e potenza. La forma acetato migliora la solubilità e la biodisponibilità, rendendola adatta per uso terapeutico. Come con qualsiasi farmaco, gli effetti collaterali potenziali possono includere disturbi gastrointestinali, reazioni nel sito di iniezione e alterazioni nel metabolismo del glucosio, richiedendo un attento monitoraggio durante il trattamento.

Formula: C₄₉H₆₆N₁₀O₁₀S₂(C₂H₄O₂)

InChI: InChI=1/C49H66N10O10S2.C2H4O2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41;1-2(3)4/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64);1H3,(H,3,4)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+;/m1./s1

Sinonimi:

• L-cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl) propyl)-cyclic (2->7)-disulfide, (R-(R*,R*))
• OctreotideAcetate
• 10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate (1:2)
• (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
• (4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
• 1: PN: EP1118336 SEQID: 1 claimed protein
• 11: PN: US20030229017 PAGE: 13 claimed protein
• 14: PN: DE10147056 PAGE: 40 claimed protein
• 17: PN: US6268342 SEQID: 18 claimed protein
• 25: PN: WO2007081792 SEQID: 40 claimed protein
• L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide
• Longastatin
• Octreotide

Octreotide

CAS: 83150-76-9

A slow-release form of octreotide. Pamoate is the bivalent anion of pamoic acid (embonic acid, 4,4·-methylene-bis-(3-hydroxy-2-naphthoic acid)). CAS-number (octreotide pamoate): 135467-16-2.

Formula: C₄₉H₆₆N₁₀O₁₀S₂

Purezza: > 98%

Peso molecolare: 1019.26

Ref: 01-4076740

[R-(R*,R*)]-D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxy-methyl)propyl]-cysteinamide cyclic(2→7)-disulfide

CAS: 83150-76-9

Formula: C₄₉H₆₆N₁₀O₁₀S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1019.2393

Ref: IN-DA003A7L

Octreotide-Phenylalanine-d8 Ditrifluoroacetate

CAS: 83150-76-9

Formula: C₄₉H₅₈D₈N₁₀O₁₀S₂·2C₂HF₃O₂

Peso molecolare: 1027.30 2*114.02

Ref: 4Z-PO-036001

Octreotide

CAS: 83150-76-9

Formula: C₄₉H₆₆N₁₀O₁₀S₂

Peso molecolare: 1019.24

Ref: 7W-GP4986

Octreotide

CAS: 83150-76-9

Octreotide

Purezza: ≥98%

Peso molecolare: 1019.24g/mol

Ref: 54-BUP00965

Octreotide

CAS: 83150-76-9

Octreotide (SMS 201-995) is a potent inhibitor of growth hormone, glucagon, and insulin.

Formula: C₄₉H₆₆N₁₀O₁₀S₂

Purezza: 99.3% - 99.64%

Colore e forma: White Powder

Peso molecolare: 1019.24

Ref: TM-T2584

Octreotide-phenylalanine-d8 di-Trifluoroacetic Acid Salt

Prodotto controllato

CAS: 83150-76-9

Applications Labelled octapeptide analog of Somatostatin. A gastric antisecretory agent. Used in treatment of acromegaly.
References Bauer, W., et al.: Life Sci., 31, 1133 (1982), Plewe, G., et al.: Lancet, 2, 782 (1984), Kraenzlin, M.E., et al.: Experientia, 41, 738 (1985), del Pozo, E., et al.: Acta Endocrinol., 111, 433 (1986),

Formula: C₅₃H₆₀D₈F₆N₁₀O₁₄S₂

Colore e forma: Neat

Peso molecolare: 1255.34

Ref: TR-O239952

13C6-Lys Octreotide Trifluoroacetate

Prodotto controllato

CAS: 83150-76-9

Formula: C₄₃₁₃C₆H₆₆N₁₀O₁₀S₂•xC₂HF₃O₂

Colore e forma: White To Off-White

Peso molecolare: 1025.2011402

Ref: TR-O239958

Octreotide

CAS: 83150-76-9

Octreotide is a drug that belongs to the macrocycle class of polymers. It is used in the treatment of cancer, as well as for diseases such as diabetes mellitus and acromegaly. Octreotide has been shown to inhibit p-glycoprotein (P-gp) and other drug transporters, which leads to an increase in oral bioavailability. In addition, octreotide also inhibits cellular proliferation by interfering with intracellular signalling pathways and protein synthesis. This drug has been shown to have a wide range of biochemical properties and is being investigated as an investigational agent for the treatment of various cancers.

Formula: C₄₉H₆₆N₁₀O₁₀S₂

Purezza: Min. 95%

Peso molecolare: 1,019.24 g/mol

Ref: 3D-OCT-3738-PI

Octreotide

CAS: 83150-76-9

Octreotide is a synthetic somatostatin analogue used for the treatment of acromegaly and neuroendocrine tumours. In clinical settings, Octreotide is used for the treatment of vasoactive intestinal peptide-secreting tumours, growth hormone producing tumours, and pituitary tumours. Octreotide also displays efficacy in the treatment of cluster headaches, acute haemorrhage from liver cirrhosis, malignant bowel obstruction, and idiopathic intracranial hypertension. Octreotide exerts its organ protective effects through several mechanisms, including its ability to decrease the levels of endotoxin and the proinflammatory cytokines TNF-alpha and IL-1β, and by inhibiting hepatocellular apoptosis. Octreotide also exerts a protective effect in hepatic ischemia-reperfusion (HIR) injury, which often occurs after complex liver surgeries such as major resection or transplantation.

Peso molecolare: 1,018.4 g/mol

Ref: 3D-CRB1001491