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CAS 83314-01-6

:

Briostatina 1

Descrizione:
Briostatina 1 è un prodotto naturale derivato dal briozoo marino Bugula neritina, noto per la sua struttura complessa e significativa attività biologica. È classificato come una lattone macrociclica ed espone una struttura policiclica unica che contribuisce alle sue proprietà farmacologiche. Briostatina 1 è principalmente riconosciuto per il suo ruolo come modulatore della proteina chinasi C (PKC), influenzando vari processi cellulari come la differenziazione, la proliferazione e l'apoptosi. Le sue potenziali applicazioni terapeutiche sono in fase di esplorazione nel trattamento del cancro, delle malattie neurodegenerative e del potenziamento cognitivo. Il composto è caratterizzato dalla sua capacità di attivare determinate vie di segnalazione, il che può portare a effetti neuroprotettivi. Inoltre, Briostatina 1 ha mostrato promesse in studi clinici per condizioni come la malattia di Alzheimer, evidenziando la sua importanza nella chimica medicinale. Tuttavia, la sua sintesi complessa e la disponibilità limitata pongono sfide per un uso diffuso. In generale, Briostatina 1 rappresenta un esempio affascinante di come i prodotti naturali possano portare a significativi progressi nella farmacologia e nello sviluppo terapeutico.
Formula:C47H68O17
InChI:InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
InChI key:InChIKey=MJQUEDHRCUIRLF-TVIXENOKSA-N
SMILES:O[C@]12[C@@H](OC(/C=C/C=C/CCC)=O)\C(=C\C(OC)=O)\C[C@](O1)(C[C@]([C@@H](C)O)(OC(=O)C[C@H](O)C[C@]3(O[C@@](O)(C[C@]4(O[C@@](\C=C\C2(C)C)(C/C(=C\C(OC)=O)/C4)[H])[H])C(C)(C)[C@@H](OC(C)=O)C3)[H])[H])[H]
Sinonimi:
  • (1S,3S,5E,13E,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
  • (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1~3,7~.1~11,15~]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
  • 18,27,28,29-Tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacosane, bryostatin 1 deriv.
  • 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacos-8-en-12-yl ester, (2E,4E)-
  • 2,4-Octadienoic acid, 25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacos-8-en-12-yl ester, [1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-
  • Bmy-45618
  • Bryostatin 1
  • Nsc-339555
  • [1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1<sup>3,7</sup>.1<sup>11,15</sup>]nonacos-8-en-12-yl 2,4-octadienoate
  • 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, (2E,4E)-
  • Vedi altri sinonimi
Ordinare per
Purezza (%)
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100
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50
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90
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95
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100
4 prodotti.
  • Bryostatin 1
    Targetmol
    + Info

    Bryostatin 1

    CAS:
    <p>Bryostatin 1, a marine macrolide, permeates CNS and modulates PKC, with strong affinity for Munc13-1 (Ki: 8.07 nM and 0.45 nM).</p>
    Formula:C47H68O17
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:905.03

    Ref: TM-T14831

  • Bryostatin
    Glentham
    + Info

    Bryostatin

    CAS:
    Formula:C47H68O17
    Peso molecolare:905.03

    Ref: 7W-GK5412

    ne
    Prezzo su richiesta
  • Bryostatin 1
    Apollo Scientific
    + Info

    Bryostatin 1

    CAS:
    <p>Bryostatin 1</p>
    Colore e forma:White Lyophilised Powder
    Peso molecolare:905.03g/mol

    Ref: 54-BIB0342

    25µg
    456,00€
  • Bryostatin 1
    Biosynth
    + Info

    Bryostatin 1

    CAS:
    <p>Bryostatin 1 is a cyclic lipopeptide that has been shown to induce apoptosis in cells by inhibiting protein kinase activity. Bryostatin 1 induces the release of mitochondrial cytochrome c and other pro-apoptotic proteins from the mitochondria into the cytosol, which leads to cell death. This drug has also been shown to increase intracellular levels of Ca2+, leading to activation of proteases such as calpain. It also inhibits DNA methyltransferase, which may make it useful for the treatment of cancer.</p>
    Formula:C47H68O17
    Purezza:Min. 95%
    Peso molecolare:905.04 g/mol

    Ref: 3D-IDA31401

    10µg
    607,00€