CAS 83602-41-9

(1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-etil-1,7,10,16,20,23,25,26,31-nonametil-14,32-bis(1-metiletil)-11,17,26,29-tetrakis(2-metilpropil)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazaciclotritriacont

Descrizione:

La sostanza chimica con il nome "(1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-etil-1,7,10,16,20,23,25,26,31-nonametil-14,32-bis(1-metiletil)-11,17,26,29-tetrakis(2-metilpropil)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazaciclotritriacont" e numero CAS "83602-41-9" è un composto organico complesso caratterizzato dalla sua struttura intricata, che include più centri chirali e un numero significativo di gruppi funzionali. Questa sostanza probabilmente presenta un alto peso molecolare a causa della sua estesa catena di carbonio e dei numerosi sostituenti, contribuendo alla sua potenziale attività biologica. La presenza di più gruppi oxo suggerisce che potrebbe avere applicazioni in chimica medicinale o nella scienza dei materiali. Inoltre, la stereochimica indicata dalle designazioni R e S implica che il composto potrebbe mostrare interazioni specifiche con bersagli biologici, rendendolo di interesse in farmacologia. La sua solubilità, stabilità e reattività dipenderebbero dai gruppi funzionali specifici e dall'architettura molecolare complessiva, che potrebbero influenzare il suo comportamento in vari ambienti chimici.

Formula: C₆₄H₁₁₃N₁₁O₁₃

InChI: InChI=1/C64H113N11O13/c1-26-28-29-41(15)53(88-44(18)76)52-57(81)67-45(27-2)59(83)70(20)34-49(77)71(21)47(31-36(5)6)56(80)69-50(39(11)12)61(85)72(22)48(32-37(7)8)55(79)65-42(16)54(78)66-43(17)58(82)75(25)64(19,33-38(9)10)63(87)68-46(30-35(3)4)60(84)73(23)51(40(13)14)62(86)74(52)24/h26,28,35-43,45-48,50-53H,27,29-34H2,1-25H3,(H,65,79)(H,66,78)(H,67,81)(H,68,87)(H,69,80)/b28-26+/t41-,42+,43-,45+,46+,47+,48+,50+,51+,52+,53-,64+/m1/s1

Sinonimi:

• o-Acetyl C(9) cyclosporin a
• Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(acetyloxy)-4-methyl-2-(methylamino)-6-octenoic acid]-
• (3R,4R)-3-Acetoxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• Cyclosporin A Acetate
• Aids097134
• (3R,4R)-3-Acetoxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• SDZ 33-243
• Sdz 033-243
• Cyclosporin A O-Acetyl Impurity
• (3R,4R)-N-Methyl-3-acetoxy-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
• O-Acetylcyclosporin A
• Cyclosporine A acetate
• 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-Methyl-2-(MethylaMino)-6-octenoic acid] Cyclosporin A
• Acetylcyclosporin A
• B-3-243
• Aids-097134

Cyclosporin A Acetate

CAS: 83602-41-9

Formula: C₂₆H₄₆N₃O₅

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 480.6605

Ref: IN-DA0057EE

Cyclosporin A-13C2,d4 Acetate

Prodotto controllato

CAS: 83602-41-9

Applications Labelled Cyclosporin A (C988901) derivative. An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005)

Formula: C₆₂C₂H₁₀₉D₄N₁₁O₁₃

Colore e forma: Neat

Peso molecolare: 1250.65

Ref: TR-C988893

Cyclosporin A-d4 Acetate (Major)

Prodotto controllato

CAS: 83602-41-9

Applications A non-immunosuppressive analog of Cyclosporin A.
References Twentyman, P. R., et al.: Brit. J. Cancer, 57, 254 (1988), Twentyman, P. R., et al.: Brit. J. Cancer, 65, 335 (1992), Schneider, H., et al.: Biochem., 33, 8218 (1994).

Formula: C₆₄H₁₀₉D₄N₁₁O₁₃

Colore e forma: Neat

Peso molecolare: 1248.67

Ref: TR-C988892

Cyclosporin A Acetate

CAS: 83602-41-9

Formula: C₆₄H₁₁₃N₁₁O₁₃

Peso molecolare: 1244.7

Ref: ST-EA-CP-C162052

Cyclosporin A acetate

CAS: 83602-41-9

Cyclosporin A is a cyclic non-hydrolyzable glycol ester that inhibits the production of cytokines and inflammatory mediators by binding to specific intracellular receptors. Cyclosporin A acetate is an inactive prodrug that is converted to active cyclosporine in the liver. Cyclosporin A acetate has been shown to be effective in treating autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as atopic dermatitis. Cyclosporin A acetate is used orally and usually taken with food or milk to reduce gastrointestinal irritation. The oral dosage form of this drug contains saccharose as a diluent and surfactant, which reduces the risk of gastrointestinal irritation.

Formula: C₆₄H₁₁₃N₁₁O₁₃

Purezza: (%) Min. 95%

Colore e forma: Powder

Peso molecolare: 1,244.65 g/mol

Ref: 3D-FC20751