CAS 842133-18-0

Canagliflozina

Descrizione:

Canagliflozina è un farmaco utilizzato principalmente nella gestione del diabete mellito di tipo 2. Appartiene a una classe di farmaci noti come inibitori del cotrasportatore sodio-glucosio 2 (SGLT2), che funzionano prevenendo il riassorbimento della glucosio nei reni, promuovendo così la sua escrezione nelle urine e abbassando i livelli di glucosio nel sangue. La formula chimica di Canagliflozina è C21H25ClO5S, e presenta un gruppo sulfonilico, un moiety di clorobenzene e una struttura simile al glucosio, che contribuiscono alla sua attività farmacologica. Canagliflozina è tipicamente somministrato per via orale ed è noto per i suoi potenziali benefici oltre al controllo glicemico, inclusa la perdita di peso e la protezione cardiovascolare. Gli effetti collaterali comuni possono includere infezioni del tratto urinario e disidratazione. Come con qualsiasi farmaco, è essenziale che i pazienti consultino professionisti sanitari per consigli personalizzati e monitoraggio durante l'uso di Canagliflozina.

Formula: C₂₄H₂₅FO₅S

InChI: InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1

InChI key: InChIKey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC=3SC(=CC3)C4=CC=C(F)C=C4)=C(C)C=C2

Sinonimi:

• (1S)-1,5-Anhydro-1-C-(3-((5-(4-Fluorophenyl)-2-Thienyl)Methyl)-4-Methylphenyl)-D-Glucitol
• (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-<span class="text-smallcaps">D</span>-glucitol
• 1-(β-<span class="text-smallcaps">D</span>-Glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
• 1-(β-D-glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienyl-methyl) benzene
• <span class="text-smallcaps">D</span>-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
• Canaglifozin
• Invokana
• Jnj 24831754Zae
• Jnj 28431754
• Jnj 28431754Aaa
• Ta 7284
• Canagliflozin
• D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
• D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl
• (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
• Canagliflozi
• Cango coluMn net
• Canagliflozin WS
• Canagliflozin, >=98%
• Canaglifozion
• Canagliflozin-D6
• Canagliflozin(TA-7284)

Canagliflozin

CAS: 842133-18-0

Canagliflozin

Purezza: ≥98%

Peso molecolare: 444.52g/mol

Ref: 54-BUP17778

Canagliflozin

CAS: 842133-18-0

Canagliflozin

Purezza: 99%

Peso molecolare: 444.52g/mol

Ref: 54-PC108773

Canagliflozin

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₅S

Colore e forma: Off-White Solid

Peso molecolare: 444.52

Ref: 4Z-C-152002

Canagliflozin

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₅S

Purezza: ≥ 98.0%

Colore e forma: White to yellow solid

Peso molecolare: 444.52

Ref: 7W-GX8313

CANAGLIFLOZIN

CAS: 842133-18-0

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 444.519989013672

Ref: 10-F857122

Canagliflozin

CAS: 842133-18-0

Colore e forma: Neat

Ref: 86-MM3870.00

Canagliflozin

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₅S

Colore e forma: Neat

Peso molecolare: 444.52

Ref: 04-CA10945450

Canagliflozin-13C6

CAS: 842133-18-0

Formula: C₁₈₁₃C₆H₂₅FO₅S

Peso molecolare: 450.47

Ref: 4Z-C-152049

Canagliflozin

CAS: 842133-18-0

Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.

Formula: C₂₄H₂₅FO₅S

Purezza: 98.01% - >99.99%

Colore e forma: Solid

Peso molecolare: 444.52

Ref: TM-T1782

Canagliflozin

Prodotto controllato

CAS: 842133-18-0

Applications Canagliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);

Formula: C₂₄H₂₅FO₅S

Colore e forma: Colourless

Peso molecolare: 444.52

Ref: TR-C175190

1,5-Dihydroxy Canagliflozin

Prodotto controllato

CAS: 842133-18-0

Formula: C₂₄H₂₇FO₆S

Colore e forma: Neat

Peso molecolare: 462.531

Ref: TR-D450431

Canagliflozin

CAS: 842133-18-0

Canagliflozin is a drug that has been approved for the treatment of type 2 diabetes. It is an inhibitor of sodium glucose transporter 2 (SGLT2) and reduces blood glucose levels by increasing urinary glucose excretion. Canagliflozin has been shown to have cardiac effects, which may be due to its ability to increase serum natriuretic peptide levels and decrease heart rate. This drug has also been shown to reduce cardiovascular disease activity in patients with type 2 diabetes. Canagliflozin is not active against c. glabrata, but it does inhibit SGLT1 in this organism.

Formula: C₂₄H₂₅FO₅S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 444.52 g/mol

Ref: 3D-MC58356

2'-Deshydroxymethyl-2'-Chloromethyl-6'-methoxy-canagliflozin

Prodotto controllato

CAS: 842133-18-0

Formula: C₂₅H₂₆ClFO₅S

Colore e forma: Neat

Peso molecolare: 492.987

Ref: TR-D221670

2'-Deshydroxymethyl-2'-Chloromethyl-canagliflozin

Prodotto controllato

CAS: 842133-18-0

Formula: C₂₄H₂₄ClFO₄S

Colore e forma: Neat

Peso molecolare: 462.961

Ref: TR-D221665

(3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-2-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Prodotto controllato

CAS: 842133-18-0

Formula: C₂₅H₂₇FO₆S

Colore e forma: Neat

Peso molecolare: 474.542

Ref: TR-F953260

Canagliflozin Tetra-acetyloxy

Prodotto controllato

CAS: 842133-18-0

Formula: C₃₂H₃₃FO₉S

Colore e forma: Neat

Peso molecolare: 612.662

Ref: TR-C175204

(2R,3R,4R,5R)-1-(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-2,3,4,5,6-pentahydroxyhexan-1-one

Prodotto controllato

CAS: 842133-18-0

Formula: C₂₄H₂₅FO₆S

Colore e forma: Neat

Peso molecolare: 460.515

Ref: TR-F590211