CAS 84625-61-6

Itraconazolo

Descrizione:

Itraconazolo è un agente antifungino triazolico utilizzato principalmente per trattare varie infezioni fungine, comprese quelle causate da dermatofiti, lieviti e alcuni muffe. Funziona inibendo la sintesi dell'ergosterolo, un componente essenziale delle membrane cellulari fungine, interrompendo così la loro integrità e funzione. Itraconazolo è caratterizzato dalla sua relativamente bassa solubilità in acqua, ma è più solubile in solventi organici, il che influisce sulla sua biodisponibilità. Il composto ha una formula molecolare di C35H38Cl2N8O4S e presenta una struttura complessa che include un anello triazolico. Viene tipicamente somministrato per via orale o endovenosa, con la sua farmacocinetica influenzata da fattori come l'assunzione di cibo e i livelli di pH. Itraconazolo è noto per il suo ampio spettro di attività contro vari funghi, ma può anche interagire con altri farmaci a causa dei suoi effetti sugli enzimi epatici. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, elevazioni degli enzimi epatici e potenziali effetti cardiovascolari, richiedendo monitoraggio durante il trattamento.

Formula: C₃₅H₃₈Cl₂N₈O₄

InChI: InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2

InChI key: InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(CC)C)N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7

Sinonimi:

• 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
• Candistat
• Canditral
• Cladosal 100
• Fungitraxx
• Itrac
• Itraconozole
• Itralek
• Itrizole
• Oriconazole
• Orungal
• Orungamin
• Pur 1900
• R 51211
• SUBA Itraconazole
• Sempera
• Spherazole CR
• Spherazole IR
• Sporal
• Sporamelt
• Sporanox
• Sporanox IV
• Sporonox
• Traconal
• Triasporin
• cis-Itraconazole
• rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

Itraconazole, 98%

CAS: 84625-61-6

Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It?s different formulations are used to study Candida strains in murine

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: 98%

Colore e forma: White to cream, Powder or crystalline powder

Peso molecolare: 705.64

Ref: 02-J66390

Itraconazole

CAS: 84625-61-6

Colore e forma: White To Off-White

Ref: 61-FOR0258.00

Itraconazole 2.0 mg/ml in Dimethyl Sulfoxide

CAS: 84625-61-6

Colore e forma: Single Solution

Ref: 61-AMP0258.00-36

ITRACONAZOLE CRS

CAS: 84625-61-6

ITRACONAZOLE CRS

Formula: C₃₅H₃₈Cl₂N₈O₄

Colore e forma: White. Powder.

Peso molecolare: 705.6334

Ref: 41-I7000000

Itraconazole

CAS: 84625-61-6

Itraconazole

Formula: C₃₅H₃₈CI₂N₈O₄

Purezza: 99.7%

Colore e forma: White To Off-White

Peso molecolare: 900.11055

Ref: 47-1199

ITRACONAZOLE FOR SYSTEM SUITABILITY CRS

CAS: 84625-61-6

ITRACONAZOLE FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001100

Itraconazole

CAS: 84625-61-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₃₅H₃₈ClN₈O₄

Colore e forma: White Powder

Peso molecolare: 705.63

Ref: 45-1354251

Itraconazole

CAS: 84625-61-6

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 705.6334

Ref: IN-DA003R60

Itraconazole

CAS: 84625-61-6

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: 98% - 99.90%

Colore e forma: Off-White Crystalline Solid

Peso molecolare: 705.63

Ref: TM-T1011

Itraconazole

CAS: 84625-61-6

Itraconazole

Purezza: ≥98%

Peso molecolare: 705.63g/mol

Ref: 54-BUP15992

Itraconazole-d3

CAS: 84625-61-6

Formula: C₃₅H₃₅D₃Cl₂N₈O₄

Colore e forma: Off-White Solid

Peso molecolare: 708.67

Ref: 4Z-I-032

Itraconazole-d9

CAS: 84625-61-6

Formula: C₃₅H₂₉D₉Cl₂N₈O₄

Colore e forma: Off-White Solid

Peso molecolare: 714.70

Ref: 4Z-I-036

Itraconazole Impurity 5

CAS: 1217510-38-7, 84625-61-6

Formula: C₃₄H₃₅Cl₂N₈O₄·Cl

Colore e forma: Yellow Solid

Peso molecolare: 690.61 35.45

Ref: 4Z-I-0331

Itraconazole N-Oxide

CAS: 84625-61-6

Formula: C₃₅H₃₈Cl₂N₈O₅

Colore e forma: White To Off-White Solid

Peso molecolare: 721.64

Ref: 4Z-I-0329

Itraconazole

CAS: 84625-61-6

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: 99.0 - 101.0 % (dried basis)

Colore e forma: White or almost white powder

Peso molecolare: 705.63

Ref: 7W-GA0307

Itraconazole

CAS: 84625-61-6

Formula: C₃₅H₃₈Cl₂N₈O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 705.64

Ref: 4Z-I-031

Itraconazole

CAS: 84625-61-6

Itraconazole

Purezza: 98%

Peso molecolare: 705.63g/mol

Ref: 54-OR1029174

Itraconazole

CAS: 84625-61-6

Colore e forma: Neat

Ref: 86-MM0258.00

Itraconazole

Prodotto controllato

CAS: 84625-61-6

Formula: C₃₅H₃₈Cl₂N₈O₄

Colore e forma: Neat

Peso molecolare: 705.63

Ref: 04-C14485000

Itraconazole

CAS: 84625-61-6

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 705.64

Ref: 3B-I0732

Itraconazole-d9

Prodotto controllato

CAS: 84625-61-6

Applications Itraconazole-d9, is the labeled analogue of Itraconazole (I937500, an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Formula: C₃₅H₂₉D₉Cl₂N₈O₄

Colore e forma: Off-White To Beige

Peso molecolare: 714.69

Ref: TR-I937504

Itraconazole

Prodotto controllato

CAS: 84625-61-6

Applications Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993);

Formula: C₃₅H₃₈Cl₂N₈O₄

Colore e forma: White To Off-White

Peso molecolare: 705.63

Ref: TR-I937500

Itraconazole - Bio-X ™

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia.

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 705.63 g/mol

Ref: 3D-BI164594

Itraconazole

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. It also has been shown to have a glucose-lowering effect in the treatment of acute leukemia and may be used to diagnose hematopoietic stem cell or leukemia. Itraconazole is available as an oral tablet and can be administered for primary care in patients with wild-type strains of Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Trichophyton mentagrophytes. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents.

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: Min. 98.5 Area-%

Colore e forma: White Powder

Peso molecolare: 705.63 g/mol

Ref: 3D-FB24741