CAS 84625-61-6

Itraconazolo

Descrizione:

Itraconazolo è un agente antifungino triazolico utilizzato principalmente per trattare varie infezioni fungine, comprese quelle causate da dermatofiti, lieviti e alcuni muffe. Funziona inibendo la sintesi dell'ergosterolo, un componente essenziale delle membrane cellulari fungine, interrompendo così la loro integrità e funzione. Itraconazolo è caratterizzato dalla sua relativamente bassa solubilità in acqua, ma è più solubile in solventi organici, il che influisce sulla sua biodisponibilità. Il composto ha una formula molecolare di C35H38Cl2N8O4S e presenta una struttura complessa che include un anello triazolico. Viene tipicamente somministrato per via orale o endovenosa, con la sua farmacocinetica influenzata da fattori come l'assunzione di cibo e i livelli di pH. Itraconazolo è noto per il suo ampio spettro di attività contro vari funghi, ma può anche interagire con altri farmaci a causa dei suoi effetti sugli enzimi epatici. Gli effetti collaterali comuni possono includere disturbi gastrointestinali, elevazioni degli enzimi epatici e potenziali effetti cardiovascolari, richiedendo monitoraggio durante il trattamento.

Formula: C₃₅H₃₈Cl₂N₈O₄

InChI: InChI=1/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/s2

InChI key: InChIKey=VHVPQPYKVGDNFY-WGEGMAFPNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N(C(CC)C)N=C5)CO1)C6=C(Cl)C=C(Cl)C=C6)N7C=NC=N7

Sinonimi:

• 2-Butan-2-Yl-4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1,2,4-Triazol-1-Yl Methyl)-1,3-Dioxolan-4-Yl]Methoxy]Phenyl]Piperazin-1-Yl]Phenyl]-1,2,4-Triazol-3-One
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-
• 3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
• Candistat
• Canditral
• Cladosal 100
• Fungitraxx
• Itrac
• Itraconozole
• Itralek
• Itrizole
• Oriconazole
• Orungal
• Orungamin
• Pur 1900
• R 51211
• SUBA Itraconazole
• Sempera
• Spherazole CR
• Spherazole IR
• Sporal
• Sporamelt
• Sporanox
• Sporanox IV
• Sporonox
• Traconal
• Triasporin
• cis-Itraconazole
• rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

Itraconazole-d9

Prodotto controllato

CAS: 84625-61-6

Applications Itraconazole-d9, is the labeled analogue of Itraconazole (I937500, an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Formula: C₃₅H₂₉D₉Cl₂N₈O₄

Colore e forma: Off-White To Beige

Peso molecolare: 714.69

Ref: TR-I937504

Itraconazole

Prodotto controllato

CAS: 84625-61-6

Applications Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993);

Formula: C₃₅H₃₈Cl₂N₈O₄

Colore e forma: White To Off-White

Peso molecolare: 705.63

Ref: TR-I937500

Itraconazole - Bio-X ™

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia.

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 705.63 g/mol

Ref: 3D-BI164594

Itraconazole

CAS: 84625-61-6

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. It also has been shown to have a glucose-lowering effect in the treatment of acute leukemia and may be used to diagnose hematopoietic stem cell or leukemia. Itraconazole is available as an oral tablet and can be administered for primary care in patients with wild-type strains of Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, and Trichophyton mentagrophytes. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents.

Formula: C₃₅H₃₈Cl₂N₈O₄

Purezza: Min. 98.5 Area-%

Colore e forma: White Powder

Peso molecolare: 705.63 g/mol

Ref: 3D-FB24741