CAS 850140-72-6

Afatinib

Descrizione:

Afatinib è un inibitore della tirosina chinasi a piccole molecole utilizzato principalmente nel trattamento del carcinoma polmonare non a piccole cellule (NSCLC) che presenta mutazioni specifiche nel gene del recettore del fattore di crescita epidermico (EGFR). È caratterizzato dalla sua capacità di legarsi in modo irreversibile all'EGFR e ad altri membri della famiglia di recettori ErbB, inibendo così le loro vie di segnalazione che promuovono la proliferazione e la sopravvivenza cellulare. La formula chimica di Afatinib è C24H25ClFN5O3 e presenta una struttura complessa che include un anello fenilico sostituito da cloro e un moiety di piperazina. Afatinib viene somministrato per via orale ed è noto per i suoi potenziali effetti collaterali, che possono includere diarrea, eruzione cutanea e stomatite. La sua farmacocinetica indica che ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno. Il farmaco è classificato come un agente antineoplastico ed è parte della terapia mirata, rappresentando un significativo progresso nella medicina personalizzata per i pazienti con profili genetici specifici nei loro tumori.

Formula: C₂₄H₂₅ClFN₅O₃

InChI: InChI=1/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+

InChI key: InChIKey=ULXXDDBFHOBEHA-CWDCEQMOSA-N

SMILES: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Sinonimi:

• (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
• (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
• (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-dime
• 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
• Afatinib
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• Afatinib(BIBW2992MA2)
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Afatinib

CAS: 850140-72-6

Formula: C₂₄H₂₅ClFN₅O₃

Purezza: >97.0%(HPLC)(N)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 485.94

Ref: 3B-A2870

Afatinib (BIBW 2992)

CAS: 850140-72-6

Formula: C₂₄H₂₅ClFN₅O₃

Colore e forma: White To Off-White Solid

Peso molecolare: 485.95

Ref: 4Z-A-111001

Afatinib

CAS: 850140-72-6

Afatinib

Purezza: ≥95%

Peso molecolare: 485.94g/mol

Ref: 54-BUP15589

Afatinib

CAS: 850140-72-6

Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.

Formula: C₂₄H₂₅ClFN₅O₃

Purezza: 98.56% - 99.9%

Colore e forma: Off-White Solid

Peso molecolare: 485.94

Ref: TM-T21312

Afatinib-d4

CAS: 850140-72-6

Formula: C₂₄H₂₁ClFN₅O₃D₄

Peso molecolare: 489.97

Ref: 4Z-A-111002

Afatinib

CAS: 850140-72-6

Afatinib

Formula: C₂₄H₂₅ClFN₅O₃

Purezza: By hplc: >99% (Typical Value in Batch COA)

Colore e forma: white to off-white solid

Peso molecolare: 485.94g/mol

Ref: 54-BIFK0010

Afatinib, Free Base

CAS: 850140-72-6

Purezza: 99.0%

Colore e forma: Solid, No data available.

Peso molecolare: 485.94000244140625

Ref: 10-F050665

Afatinib

CAS: 850140-72-6

Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)

Formula: C₂₄H₂₅ClFN₅O₃

Colore e forma: Neat

Peso molecolare: 485.94

Ref: TR-A355300

Afatinib

CAS: 850140-72-6

Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.

Formula: C₂₄H₂₅ClFN₅O₃

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 485.94 g/mol

Ref: 3D-FC17230

Afatinib - Bio-X ™

CAS: 850140-72-6

Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.

Formula: C₂₄H₂₅ClFN₅O₃

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 485.94 g/mol

Ref: 3D-BA164141

Afatinib-d4

Prodotto controllato

CAS: 850140-72-6

Formula: C₂₄D₄H₂₁ClFN₅O₃

Colore e forma: Neat

Peso molecolare: 489.963

Ref: TR-A355302