CAS 851199-59-2

Linaclotide

Descrizione:

Linaclotide è un peptide sintetico utilizzato principalmente come farmaco per il trattamento della sindrome dell'intestino irritabile con stitichezza (SII-C) e della stitichezza idiopatica cronica (CIC). Funziona come un agonista della guanilato ciclasi-C, il che porta a un aumento dei livelli di monofosfato di guanosina ciclico (cGMP) nelle cellule epiteliali intestinali. Questa azione promuove la secrezione di fluidi nel lume intestinale e accelera il transito gastrointestinale, alleviando i sintomi della stitichezza. Linaclotide è caratterizzato dalla sua relativamente bassa biodisponibilità orale a causa della sua natura peptidica, che limita la sua assorbimento nel tratto gastrointestinale. La sostanza è tipicamente somministrata in forma di capsula ed è nota per il suo specifico meccanismo d'azione, che colpisce il rivestimento intestinale piuttosto che le vie sistemiche. Gli effetti collaterali comuni possono includere diarrea, dolore addominale e flatulenza. L'efficacia e il profilo di sicurezza di Linaclotide sono stati stabiliti attraverso studi clinici, rendendolo un'opzione preziosa nella gestione di alcuni disturbi gastrointestinali.

Linaclotide

CAS: 851199-59-2

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 1526.7365

Ref: IN-DA00G3R9

Linaclotide

CAS: 851199-59-2

Linaclotide treats IBS-C & chronic constipation; it's a selective guanylate cyclase C agonist.

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Purezza: 97.93% - 98.71%

Colore e forma: Solid

Peso molecolare: 1526.74

Ref: TM-T11852

Linaclotide

CAS: 851199-59-2

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Peso molecolare: 1526.73

Ref: 4Z-PL-121001

Linaclotide

CAS: 851199-59-2

Linaclotide

Purezza: ≥95%

Peso molecolare: 1526.74g/mol

Ref: 54-BUP05450

Linaelotide Acetate

CAS: 851199-59-2

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Purezza: 95%~99%

Colore e forma: White to Off-white Powder

Peso molecolare: 1526.74

Ref: BP-BPPG045

Linaclotide-d4

CAS: 851199-59-2

Formula: C₅₉H₇₅N₁₅O₂₁S₆D₄

Peso molecolare: 1530.78

Ref: 4Z-PL-121002

Linaclotide

CAS: 851199-59-2

Linaclotide is a drug that is used in the treatment of chronic idiopathic constipation. It is formulated with the inactive ingredients microcrystalline cellulose, croscarmellose sodium, calcium stearate, and magnesium stearate. The active ingredient is linaclotide hydrochloride. Linaclotide works by increasing intestinal motility and reducing transit time through the gastrointestinal tract. It has been shown to be effective in treating constipation in adults with chronic idiopathic constipation when taken for up to 12 weeks. Linaclotide also may be used in combination with other treatments for bowel diseases such as ulcerative colitis or Crohn's disease.
Linaclotide is metabolized primarily by cytochrome P450 3A4 (CYP3A4) and subsequently eliminated from the body primarily by renal excretion of unchanged drug or metabolites. The drug has a half-life of about 4 hours following oral administration and

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 1,526.74 g/mol

Ref: 3D-FL138962

Linaclotide

CAS: 851199-59-2

Linaclotide is a peptide drug that has been shown to be effective in treating chronic constipation. It belongs to the class of pharmacological agents and is used as a treatment for bowel disease, specifically chronic idiopathic constipation. Linaclotide increases the frequency of bowel movements by acting on the ileum and colon. This drug has been shown to be safe for use in pregnant women and children, with no adverse effects observed at doses up to 100 mcg/kg/day. The most common side effect is diarrhea, which can be managed with dietary changes or other medications. Linaclotide has not been found to interact with other drugs, but patients should always consult their doctor before taking any new medication while on linaclotide.

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Purezza: Min. 95%

Peso molecolare: 1,526.76 g/mol

Ref: 3D-LIN-3796-PI

Linaclotide

Prodotto controllato

CAS: 851199-59-2

Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Formula: C₅₉H₇₉N₁₅O₂₁S₆

Colore e forma: Neat

Peso molecolare: 1526.74

Ref: TR-L465880

Linaclotide-d4

Prodotto controllato

CAS: 851199-59-2

Applications Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Formula: C₅₉H₇₅D₄N₁₅O₂₁S₆

Colore e forma: Neat

Peso molecolare: 1530.76

Ref: TR-L465882