CAS 851443-04-4

Etil estere di rosuvastatina

Descrizione:

Etil estere di rosuvastatina, con il numero CAS 851443-04-4, è un composto sintetico appartenente alla classe dei farmaci noti come statine, utilizzato principalmente per abbassare i livelli di colesterolo e gestire le malattie cardiovascolari. È un derivato estere della rosuvastatina, nota per la sua capacità di inibire la HMG-CoA reduttasi, un enzima cruciale nella via di biosintesi del colesterolo. Il composto appare generalmente come un solido bianco o bianco sporco ed è caratterizzato dalla sua natura lipofila, che ne migliora la biodisponibilità. Etil estere di rosuvastatina è solubile in solventi organici ma ha una solubilità limitata in acqua. Il suo profilo farmacologico include un effetto potente nella riduzione del colesterolo LDL (lipoproteine a bassa densità) e dei trigliceridi, mentre aumenta il colesterolo HDL (lipoproteine ad alta densità). Il composto subisce idrolisi nel corpo per produrre la forma attiva, rosuvastatina, che esercita i suoi effetti terapeutici. Come per altre statine, gli effetti collaterali potenziali possono includere dolore muscolare, alterazioni degli enzimi epatici e disturbi gastrointestinali, richiedendo monitoraggio durante il trattamento.

Formula: C₂₄H₃₂FN₃O₆S

InChI: InChI=1/C24H32FN3O6S/c1-6-34-21(31)14-19(30)13-18(29)11-12-20-22(15(2)3)26-24(28(4)35(5,32)33)27-23(20)16-7-9-17(25)10-8-16/h7-12,15,18-19,29-30H,6,13-14H2,1-5H3/b12-11+/t18-,19-/m1/s1

Sinonimi:

• 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester
• Rosuvastatine
• ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

Ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoate

CAS: 851443-04-4

Formula: C₂₄H₃₂FN₃O₆S

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 509.5908

Ref: IN-DA004QSB

Rosuvastatin Ethyl Ester

CAS: 851443-04-4

Formula: C₂₄H₃₂FN₃O₆S

Colore e forma: White To Off-White Solid

Peso molecolare: 509.59

Ref: 4Z-R-0928

Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

CAS: 851443-04-4

Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

Purezza: 99%

Peso molecolare: 509.6g/mol

Ref: 54-PC1006224

Rosuvastatin Ethyl Ester

CAS: 851443-04-4

Colore e forma: Neat

Ref: 86-MM0936.38

Rosuvastatin Ethyl Ester

CAS: 851443-04-4

Applications Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol.
References Sterk, D.; et al.: Tetrahedron Lett., 57, 1338 (2016); Olsson, A. G.; et al.: Am. Heart J., 144, 1044 (2002).

Formula: C₂₄H₃₂FN₃O₆S

Colore e forma: Off-White To Light Beige

Peso molecolare: 509.59

Ref: TR-R700723

Rosuvastatin FP Impurity A

CAS: 851443-04-4

Formula: C₂₄H₃₂FN₃O₆S

Peso molecolare: 509.59

Ref: ST-EA-CP-R1020

7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl es ter

CAS: 851443-04-4

Rosuvastatin is a statin drug that inhibits cholesterol synthesis by inhibiting the enzyme HMG-CoA reductase. Rosuvastatin has been shown to reduce high-sensitivity C-reactive protein (hsCRP) and low-density lipoprotein cholesterol (LDL-C), which are risk factors for cardiovascular disease, in patients with hypercholesterolemia. Rosuvastatin also has a high degree of potency and specificity for the HMG-CoA reductase enzyme and shows no significant cross-reactivity with other HMG-CoA reductase inhibitors. Rosuvastatin is metabolized by CYP3A4 and CYP2C9. Drugs that inhibit these enzymes may increase the plasma levels of rosuvastatin, while drugs that induce these enzymes may decrease the plasma levels of rosuvastatin.

Formula: C₂₄H₃₂FN₃O₆S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 509.59 g/mol

Ref: 3D-FF35383

Rosuvastatin Ethyl Ester (Ethyl (3R,5S,E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate)

CAS: 851443-04-4

Sulfonamides, nesoi

Formula: C₂₄H₃₂FN₃O₆S

Colore e forma: Off-White Powder

Peso molecolare: 509.19959

Ref: 45-1A06130