CAS 863329-66-2

(2′R)-2′-Desossi-2′-fluoro-2′-metiluridina

Descrizione:

(2′R)-2′-Desossi-2′-fluoro-2′-metiluridina è un nucleoside modificato che presenta un atomo di fluoro e un gruppo metile nella posizione 2′ dello zucchero ribosio, il che lo distingue dai nucleosidi naturali. Questo composto è caratterizzato dalle sue modifiche strutturali che ne migliorano la stabilità e la bioattività, rendendolo di interesse nella chimica medicinale e nella biologia molecolare. La presenza dell'atomo di fluoro può influenzare l'interazione del composto con acidi nucleici ed enzimi, migliorando potenzialmente la sua efficacia come agente antivirale o antitumorale. Inoltre, il gruppo metile può influenzare la solubilità e la permeabilità del composto, che sono fattori critici per le applicazioni terapeutiche. La stereochimica nella posizione 2′ (designata come (2′R)) indica un particolare assetto spaziale che può influenzare l'attività biologica e il riconoscimento da parte delle polimerasi degli acidi nucleici. In generale, (2′R)-2′-Desossi-2′-fluoro-2′-metiluridina rappresenta uno strumento prezioso per la ricerca e lo sviluppo di analoghi di nucleosidi.

Formula: C₁₀H₁₃FN₂O₅

InChI: InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1

InChI key: InChIKey=ARKKGZQTGXJVKW-VPCXQMTMSA-N

SMILES: C[C@]1(F)[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C=C2

Sinonimi:

• (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
• (2'R)-2'-deoxy-2'-fluoro-2'-methyl-Uridine
• (2R)-2-Deoxy-2-fluoro-2-methyluridine
• 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
• 2'-Deoxy-2'-Fluoro-2'-C-Methyl Uridine
• 2'-Deoxy-2'-Fluoro-2'-Methyluridine
• 2-Deoxy-2-Fluoro-2-Methyl Uridine
• Gs 331007
• Psi-6206
• Ro 2433
• Sofosbuvir N-1
• Uridine, 2′-deoxy-2′-fluoro-2′-methyl-, (2′R)-
• Sofosbuvir Intermediate 4
• (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine&gt
• N4-Benzoyl-1-(2'
• -deoxy-6-methoxyguanosine
• -fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine
• -fluoro-b-D-arabinofuranosyl)purine
• -O-trityl-b-L-lyxofuranosyl)-uracil
• (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine
• -fluoro-b-D-arabinofuranosyl)cytosine HCl
• -fluoro-b-D-arabinofuranosyl)-5-ethyluracil
• -deoxy-7-ethynyladenosine
• 5. (2'R)-2'-Deoxy-2'-fluoro-2'-Methyluridine
• -biphenyl]-4-yl]methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic Acid Methyl Ester
• -fluoro-b-D-arabinofuranosyl)guanine
• -fluoro-b-D-arabinofuranosyl)cytosine
• -(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'
• -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid
• 1-(2'
• PSI 6206 int
• -deoxy-7-iodoguanosine
• -fluoro-b-D-ribofuranosyl)-2-fluoroadenine
• -fluoro-b-D-arabinofuranosyl)-5-iodouracil
• 1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]pyrimidine-2,4-dione
• 2-Fluoro-9-(2'
• 7-Deaza-2'
• -fluoro-beta-d-arabinofuranosyl)-5-ethyluracil
• -fluoroguanosine
• Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-
• 9-(2'
• 2'-deoxy-2'-fluoro-2'-C-methyluridine ISO 9001：2015 REACH
• Sofosbuvir Nucleoside Derivative (GS-331007)
• -fluoro-b-D-arabinofuranosyl)hypoxantine
• (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (Sofo C1)
• dcoxy-2-fuoro-2-C-methyhurdine
• -(Methoxycarbonyl)[1,1'
• -fluoro-b-L-arabinofuranosyl)-uracil
• -chloro-b-L-arabinofuranosyl)-thymine
• -fluoro-b-D-arabinofuranosyl)adenine
• -fluoro-b-D-arabinofuranosyl)thymine 3'
• -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid-d5
• -O-trityl-b-L-arabinofuranosyl)-uracil
• -fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3'
• 2'-deoxy-2'-fluoro-2'-C-methyluridine
• 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
• Sofosbuvir int. N-1
• -deoxy-O6-methylguanosine
• PSI-6206 (RO-2433, GS-331007)
• 2'-DEOXY-2'-FLUORO-2'-C-METHYLURIDINE,CAS 863329-66-2
• Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206
• Sofosbuvir INT 1
• 2'-Deoxy-2'-F-2'-C-methyluridine
• -deoxy-7-iodoadenosine
• Sofosbuvir imp-11
• -fluoro-a-L-arabinofuranosyl)-thymine
• 2'-Deoxy-2-floro-2'Methyl-uridine
• -deoxy-2'
• 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione RO 2433
• -C-ethynyladenosine
• -(Aminoiminomethyl)[1,1'
• Sofosbuvir Metabolite GS331007
• Sofosbuvir Intermediates 2
• PSI-6206; RO-2433; PSI6206; RO2433
• -biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylic Acid Methyl Ester
• 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
• -fluoro-b-D-ribofuranosyl)purine
• CS-832
• -O-4-C-Methylene-b-D-ribofuranosyl)thymine
• -biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylic Acid Methyl Ester
• -fluoro-b-D-ribofuranosyl)-isoguanine
• β-D-2'-deoxy-2'-α-F-2'-β-C-methyluridine
• -C-methyluridine
• -fluoro-b-D-arabinofuranosyl)uracil 3'
• 2'-deoxy-2'-fluoro-2'-C-Methyluridine　(N-1)
• -biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

PSI-6206

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 260.22

Ref: 3B-D4823

(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Purezza: 97%

Colore e forma: Solid

Peso molecolare: 260.2190

Ref: IN-DA0039OB

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

CAS: 863329-66-2

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine

Purezza: 98%

Peso molecolare: 260.22g/mol

Ref: 54-PC104925

PSI-6206

CAS: 863329-66-2

PSI-6206

Purezza: ≥98%

Peso molecolare: 260.22g/mol

Ref: 54-BUP11847

Sofosbuvir Nucleoside Derivative (GS-331007)

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Colore e forma: Off-White To Yellow Solid

Peso molecolare: 260.22

Ref: 4Z-S-055001

PSI-6206

CAS: 863329-66-2

PSI-6206 (RO 2433) (RO2433) is a selective HCV RNA polymerase inhibitor.

Formula: C₁₀H₁₃FN₂O₅

Purezza: 98% - 99.79%

Colore e forma: Solid

Peso molecolare: 260.22

Ref: TM-T2117

RO 2433

Prodotto controllato

CAS: 863329-66-2

Impurity Sofosbuvir Metabolite GS331007
Applications RO 2433 is the deaminated metabolite of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine, an effective inhibitor of hepatitis C virus (HCV) replication in vitro.
References Asif, G., et. al.: Antimicrob. Agents Ch., 51, 2877 (2007)

Formula: C₁₀H₁₃FN₂O₅

Colore e forma: Neat

Peso molecolare: 260.22

Ref: TR-R637200

Sofosbuvir Impurity 11

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Peso molecolare: 260.22

Ref: ST-EA-CP-S45010

GS 331007

CAS: 863329-66-2

Anti-viral; RNA polymerase inhibitor; sofosbuvir metabolite

Formula: C₁₀H₁₃FN₂O₅

Purezza: Min. 95%

Colore e forma: Off-White Powder

Peso molecolare: 260.22 g/mol

Ref: 3D-ND29433

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 863329-66-2

Formula: C₁₀H₁₃FN₂O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 260.221

Ref: 10-F238618