CAS 863918-55-2

5H-Pirano[3,2-d]tiazolo-6,7-diolo, 3a,6,7,7a-tetraidro-5-(idrossimetil)-2-propil-, (3aR,5R,6S,7R,7aR)-

Descrizione:

5H-Pirano[3,2-d]tiazolo-6,7-diol, 3a,6,7,7a-tetraidro-5-(idrossimetil)-2-propile-, con numero CAS 863918-55-2, è un composto organico complesso caratterizzato dalla sua unica struttura biciclica che incorpora sia un moiety di pirano che di tiazolo. Questo composto presenta più gruppi funzionali, inclusi gruppi idrossimetil e diolo, che contribuiscono alla sua potenziale reattività e solubilità in vari solventi. La stereochimica indicata dalla designazione (3aR,5R,6S,7R,7aR) suggerisce specifici arrangiamenti spaziali dei suoi atomi, che possono influenzare la sua attività biologica e le interazioni con altre molecole. Composti di questo tipo possono mostrare interessanti proprietà farmacologiche, rendendoli di interesse nella chimica medicinale. La presenza del gruppo propile migliora le sue caratteristiche idrofobiche, influenzando potenzialmente la sua biodisponibilità e interazione con le membrane biologiche. In generale, la complessità strutturale e la diversità funzionale di questo composto suggeriscono potenziali applicazioni nello sviluppo di farmaci e in altri campi della ricerca chimica.

Formula: C₁₀H₁₇NO₄S

Sinonimi:

• 5H-Pyrano[3,2-d]thiazole-6,7-diol, 3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-2-propyl-, (3aR,5R,6S,7R,7aR)-

NButGT - Bio-X ™

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.  Linagliptin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₇NO₄S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 247.31 g/mol

Ref: 3D-BN300156

NButGT

CAS: 863918-55-2

NButGT (N-butyryl-glucosamine-1,5-lactone O-(phenylcarbamoyl)oxime) is a selective inhibitor of O-GlcNAcase (OGA), the enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. It effectively increases O-GlcNAc levels in cells and tissues without altering hexosamine biosynthetic pathway enzyme expression. It has also been shown that NButGT rapidly increases O-GlcNAcylation of mitochondrial proteins involved in oxidative phosphorylation and metabolism. While effective, NButGT served as a precursor to more potent OGA inhibitors like Thiamet-G. These findings highlight NButGT's importance as a tool for studying O-GlcNAcylation in various biological contexts, particularly in cardiac and neurological research. For example, in recent cardiac studies, NButGT pretreatment has demonstrated an improvement in cardiac output and mitochondrial respiration when combined with epinephrine.

Formula: C₁₀H₁₇NO₄S

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 247.31 g/mol

Ref: 3D-NN180123