CAS 86408-36-8

cloridrato di polimixina B nonapeptide

Descrizione:

cloridrato di polimixina B nonapeptide è un derivato sintetico della polimixina B, un antibiotico derivato dal batterio Bacillus polymyxa. Questo composto è caratterizzato dalla sua struttura, che consiste in un peptide ciclico con una coda idrofobica, contribuendo alla sua capacità di interrompere le membrane cellulari batteriche. Mostra una potente attività antimicrobica, in particolare contro i batteri Gram-negativi, rendendolo prezioso in contesti clinici per il trattamento di infezioni causate da organismi multiresistenti. La forma cloridrato ne migliora la solubilità in soluzioni acquose, facilitando il suo utilizzo in varie formulazioni farmaceutiche. cloridrato di polimixina B nonapeptide è anche noto per la sua minore tossicità rispetto ad altre polimixine, il che è vantaggioso per le applicazioni terapeutiche. Inoltre, è stato studiato per il suo potenziale utilizzo in terapie combinate per aumentare l'efficacia di altri antibiotici. Il suo meccanismo d'azione coinvolge principalmente il legame ai lipopolisaccaridi nella membrana esterna batterica, portando alla lisi cellulare. In generale, questo composto rappresenta uno strumento significativo nella lotta contro le infezioni resistenti agli antibiotici.

Formula: C₄₃H₇₄N₁₄O₁₁

InChI: InChI=1/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64)/t23-,24-,26+,27+,28+,29+,30+,31+,32-,33+,34+/m1/s1

Sinonimi:

• Polymyxin B nonapeptide
• Pmbn
• Polymyxin B cyclononapeptide
• Polymyxin B1, 1-de(N2-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoic acid)-
• N-[(2S)-4-amino-1-oxo-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}butan-2-yl]-L-threoninamide

(2S,3R)-2-amino-N-[(1S)-3-amino-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]-3-hydroxy-butanamide

CAS: 86408-36-8

Formula: C₄₃H₇₄N₁₄O₁₁

Purezza: 98%

Peso molecolare: 963.1349

Ref: IN-DA004XCE

Polymyxin B nonapeptide

CAS: 86408-36-8

Polymyxin B nonapeptide boosts hydrophobic antibiotic uptake in Gram-negative bacteria by enhancing membrane permeability.

Formula: C₄₃H₇₄N₁₄O₁₁

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 963.13

Ref: TM-TP1341

Polymyxin B nonapeptide hydrochloride

CAS: 86408-36-8

Polymyxin B nonapeptide hydrochloride is a potent antibiotic compound derived from the bacterium *Bacillus polymyxa*. As a cationic polypeptide, it exhibits its antibacterial activity by interacting with the lipopolysaccharides and phospholipids in the bacterial cell membrane, leading to increased permeability and ultimately causing cell lysis. The compound is specifically effective against a broad range of Gram-negative bacteria, making it crucial in studying antibiotic resistance mechanisms.

Formula: C₄₃H₇₄N₁₄O₁₁•(HCl)x

Purezza: Min. 95%

Peso molecolare: 963.14 g/mol

Ref: 3D-AP182838

Polymyxin B Nonapeptide

Prodotto controllato

CAS: 86408-36-8

Formula: C₄₃H₇₄N₁₄O₁₁

Colore e forma: Neat

Peso molecolare: 963.135

Ref: TR-P689398

Polymyxin B nonapeptide

CAS: 86408-36-8

Polymyxin B nonapeptide is a polymyxin antibiotic that is effective against Gram-negative bacteria. It has been shown to inhibit the growth of wild-type strains of Escherichia coli and Salmonella enterica in laboratory tests, as well as cancer tissues. Polymyxin B nonapeptide binds to the il-2 receptor on human cells and inhibits the activation of interleukin 2, which is an important immune response regulator. The drug also has biocompatible properties and does not cause any significant physiological effects or alterations in redox potentials when injected into humans. This antibiotic has a phase transition temperature of 56°C and can be used for treating tissue infections caused by bacteria with a high resistance to antibiotics.

Formula: C₄₃H₇₄N₁₄O₁₁

Purezza: Min. 95%

Peso molecolare: 963.1 g/mol

Ref: 3D-LDA40836