CAS 87-33-2

Dinitrato di isosorbide

Descrizione:

Dinitrato di isosorbide (ISDN) è un composto di nitrato organico utilizzato principalmente come vasodilatatore nel trattamento dell'angina pectoris e dell'insufficienza cardiaca. È un solido cristallino incolore o giallo pallido, solubile in acqua e solventi organici. La formula chimica di Dinitrato di isosorbide è C7H10N2O5 e presenta due gruppi nitrato esterificati allo scheletro di isosorbide. L'ISDN agisce rilasciando ossido nitrico, che rilassa il muscolo liscio vascolare, portando alla dilatazione dei vasi sanguigni e a un miglioramento del flusso sanguigno. Il composto viene tipicamente somministrato in forme orali o sublinguali, e la sua farmacocinetica include un rapido inizio d'azione con una vita media relativamente breve. Gli effetti collaterali comuni possono includere mal di testa, vertigini e ipotensione. A causa del suo potenziale per lo sviluppo di tolleranza, i regimi di dosaggio spesso comportano un uso intermittente. Dinitrato di isosorbide è utilizzato anche in contesti di ricerca per studiare la funzione vascolare e le vie di segnalazione dell'ossido nitrico. Sono necessarie precauzioni di sicurezza quando si maneggia questo composto, poiché può essere sensibile al calore e agli urti.

Formula: C₆H₈N₂O₈

InChI: InChI=1/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key: InChIKey=MOYKHGMNXAOIAT-JGWLITMVSA-N

SMILES: O(N(=O)=O)[C@H]1[C@@]2([C@@]([C@@H](ON(=O)=O)CO2)(OC1)[H])[H]

Sinonimi:

• 1,4,3,6-Sorbido-2,5-dinitric acid ester
• 1,4:3,6-Dianhydro-<span class="text-smallcaps">D</span>-glucitol 2,5-dinitrate
• 1,4:3,6-Dianhydro-<span class="text-smallcaps">D</span>-sorbitol 2,5-dinitrate
• 1,4:3,6-Dianhydro-D-glucitol 2,5-dinitrate
• 1,4:3,6-Dianhydro-D-sorbitol 2,5-dinitrate
• 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate
• <span class="text-smallcaps">D</span>-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
• <span class="text-smallcaps">D</span>-Glucitol, 1,4:3,6-dianhydro-, dinitrate
• <span class="text-smallcaps">D</span>-Isosorbide dinitrate
• Astridine
• Cardiket
• Cardio 10
• Cardis
• Carvanil
• Carvasin
• Cedocard
• Claodical
• Corosorbide
• Corovliss
• D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate
• D-Isosorbide dinitrate
• Dignionitrat
• Dilatrate
• Dilatrate SR
• Diniket
• Dinitrate d'isosorbide
• Dinitrato De Isosorbida
• Dinitroisosorbide
• Dinitrosorbide
• Disorlon
• Duranitrat
• EureCor
• Ev 151
• Flindix
• Frandol
• Furo[3,2-b]furan, <span class="text-smallcaps">D</span>-glucitol deriv.
• Glentonin
• Glucitol, 1,4:3,6-dianhydro-, dinitrate
• Glucitol, 1,4:3,6-dianhydro-, dinitrate, <span class="text-smallcaps">D</span>-
• Glucitol, 1,4:3,6-dianhydro-, dinitrate, D-
• Harrical
• IBD
• Imtack
• Isdin
• Isdn
• Iso-Bid
• Iso-Mack
• Iso-Puren
• Isocard
• Isocore
• Isodinit
• Isoket
• Isoket retard 40
• Isonate?
• Isorbid
• Isordil
• Isordil Tembids
• Isosorbiddinitrat
• Isosorbide 2,5-dinitrate
• Isosorbide Dinitrate
• Isosorbide dinitrate mixture
• Isosorbide nitrate
• Isostenase
• Isotrate
• Korodil
• Langoran
• Laserdil
• Maycor
• Mixture, Isosorbide Dinitrate
• Myorexon
• Nitorol
• Nitrofix
• Nitrol
• Nitrosorbid
• Nitrosorbide
• Nitrosorbonl Nosim
• Nsc 80038
• Resoidan
• Rifloc Retard
• Rigedal
• Risordan
• Sdm 25
• Sdm 40
• Soni-Slo
• Sorbangil
• Sorbichew
• Sorbid SA
• Sorbide dinitrate
• Sorbide nitrate
• Sorbidilat
• Sorbidnitrate
• Sorbitol, 1,4:3,6-dianhydro-, dinitrate
• Sorbitrate
• Sorbonit
• Sorbopercuten
• Sorquad
• Tyb 3215
• Vascardin
• Vasorbate
• Vasotrate
• 1,4:3,6-dianhydro-2,5-di-O-nitrohexitol
• D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
• 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
• Isosobide dinitrate
• 1,4:3,6-dianhydrosorbitol2,5-dinitrate
• 1,4:3,6-dianhydro-,dinitrate,d-glucito
• 1,4:3,6-dianhydro-d-glucitodinitrate
• dianhydrosorbitol2,5-dinitrate
• isochron

ISOSORBIDE DINITRATE CRS

CAS: 87-33-2

ISOSORBIDE DINITRATE CRS

Formula: C₆H₈N₂O₈

Colore e forma: Powder.

Peso molecolare: 236.1363

Ref: 41-I0775000

Diluted Isosorbide Dinitrate

CAS: 87-33-2

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₆H₈N₂O₈

Colore e forma: White Powder

Peso molecolare: 236.02807

Ref: 45-1353000

Isosorbide dinitrate

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 236.1363

Ref: IN-DA003R5M

Isosorbide dinitrate

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Purezza: ≥ 98% (isosorbide dinitrate)

Colore e forma: White to off-white powder

Peso molecolare: 236.14

Ref: 7W-GC6329

Isosorbide dinitrate

CAS: 87-33-2

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

Formula: C₆H₈N₂O₈

Purezza: 99.87%

Colore e forma: Hard Colorless Crystals Solid

Peso molecolare: 236.14

Ref: TM-T1479

Isosorbide dinitrate - 60% lactose and 40% Isosorbide dinitrate

CAS: 87-33-2

Isosorbide dinitrate is used to treat chronic bronchitis and congestive heart failure. It dilates blood vessels, allowing more oxygen-rich blood to reach the heart. Isosorbide dinitrate is also used to relieve chest pain (angina) and reduce complications after a heart attack. Isosorbide dinitrate is a prodrug that is converted in vivo to its active form, isosorbide mononitrate, by the enzyme nitric oxide synthase in response to hypoxia. In addition, it has been shown that this drug reduces levels of low-density lipoprotein cholesterol (LDL-C) and may be useful for the treatment of high cholesterol.
The mechanism of action for reducing LDL-C levels is not known but may be due to increased clearance of LDL-C from plasma or decreased production of very low density lipoproteins (VLDL). This medication does not affect triglycerides or high density lip

Formula: C₆H₈N₂O₈

Purezza: Min. 95%

Colore e forma: White Powder

Peso molecolare: 236.14 g/mol

Ref: 3D-MI09907

Isosorbide Mononitrate EP Impurity A

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Peso molecolare: 236.14

Ref: ST-EA-CP-I24001

Isosorbide Dinitrate

CAS: 87-33-2

Formula: C₆H₈N₂O₈

Peso molecolare: 236.14

Ref: 4Z-I-194