CAS 87081-36-5

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Diidro-3-metil-6-osso-2H-pirano-2-il]-6-idrossi-3,5,7,9,11,15,17-eptametil-8-osso-2,10,12,16,18-nonadecapentaenoico acido

Descrizione:

La sostanza chimica con il nome "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Diidro-3-metil-6-osso-2H-pirano-2-il]-6-idrossi-3,5,7,9,11,15,17-eptametil-8-osso-2,10,12,16,18-nonadecapentaenoico acido" e numero CAS "87081-36-5" è un composto organico complesso caratterizzato dai suoi molteplici stereocentri e gruppi funzionali. Presenta una lunga catena di carbonio con diversi doppi legami, il che indica che probabilmente è un derivato di un acido grasso polinsaturo. La presenza di gruppi idrossilici e chetonici suggerisce che potrebbe mostrare una reattività significativa e una potenziale attività biologica. La stereochimica specifica, denotata dalle configurazioni (E) e (Z), implica che il composto potrebbe avere disposizioni spaziali uniche che influenzano le sue interazioni nei sistemi biologici. Tali composti sono spesso studiati per i loro ruoli nei prodotti naturali, nelle potenziali applicazioni terapeutiche o come intermedi nella chimica sintetica. In generale, questa sostanza esemplifica la complessità e la diversità presenti nella chimica organica, in particolare nel campo della sintesi e modifica dei prodotti naturali.

Formula: C₃₂H₄₆O₆

InChI: InChI=1/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+

InChI key: InChIKey=QECBVZBMGUAZDL-WRDLAOIUSA-N

SMILES: C(=C/C(=C\[C@@H](C/C=C/C(=C/[C@H](C([C@H]([C@@H]([C@H](C/C(=C/C(O)=O)/C)C)O)C)=O)C)/C)C)/C)\[C@H]1[C@@H](C)C=CC(=O)O1

Sinonimi:

• (2E,10E,12E,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-
• 2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-, (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
• Jildamycin
• Leptomycin A
• NSC 369326
• QECBVZBMGUAZDL-DLWOFZAMSA-N
• 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
• Antibiotic ATS-1287A
• PD-118607
• ATS 1287A, PD 118607, JildaMycin
• 19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
• Antibiotic PD-118607

Leptomycin A

CAS: 87081-36-5

Formula: C₃₂H₄₆O₆

Peso molecolare: 526.7

Ref: 7W-GA3048

Leptomycin A

CAS: 87081-36-5

Leptomycin A

Peso molecolare: 526.70g/mol

Ref: 54-BIL2100

Leptomycin A

CAS: 87081-36-5

Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.

Formula: C₃₂H₄₆O₆

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 526.7

Ref: TM-T11837

Leptomycin A

CAS: 87081-36-5

Leptomycin A is a Streptomyces-produced inhibitor, which is derived from the bacterium Streptomyces spiroverticillatus. It functions by specifically binding to and inhibiting the CRM1 (exportin 1), a nuclear export receptor. This action blocks the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES), thereby leading to their accumulation within the nucleus. The inhibition of CRM1 disrupts various cellular processes, including cell cycle regulation and signal transduction pathways.

Formula: C₃₂H₄₆O₆

Purezza: Min. 95%

Peso molecolare: 526.7 g/mol

Ref: 3D-MDA08136