CAS 871224-64-5

Almorexant

Descrizione:

Almorexant è un composto chimico classificato come antagonista duale dei recettori dell'orexina, principalmente studiato per il suo potenziale utilizzo nel trattamento dell'insonnia e di altri disturbi del sonno. Funziona bloccando selettivamente l'azione dei neuropeptidi dell'orexina, che svolgono un ruolo cruciale nella regolazione dell'eccitazione, della vigilanza e dell'appetito. La struttura molecolare di Almorexant presenta un'architettura complessa che contribuisce alla sua attività farmacologica, sebbene dettagli specifici sulle sue proprietà fisiche, come solubilità e stabilità, si trovino tipicamente in database specializzati o nella letteratura scientifica. Almorexant ha subito vari studi clinici per valutare la sua efficacia e il profilo di sicurezza, dimostrando promesse nella promozione del sonno senza gli effetti avversi comunemente associati ai sedativi tradizionali. Come molti farmaci in fase di studio, il suo stato di sviluppo può variare e la ricerca in corso continua a esplorare il suo pieno potenziale terapeutico e meccanismo d'azione.

Formula: C₂₉H₃₁F₃N₂O₃

InChI: InChI=1S/C29H31F3N2O3/c1-33-28(35)27(20-7-5-4-6-8-20)34-16-15-21-17-25(36-2)26(37-3)18-23(21)24(34)14-11-19-9-12-22(13-10-19)29(30,31)32/h4-10,12-13,17-18,24,27H,11,14-16H2,1-3H3,(H,33,35)/t24-,27+/m0/s1

InChI key: InChIKey=DKMACHNQISHMDN-RPLLCQBOSA-N

SMILES: C(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2C=3C(=CC(OC)=C(OC)C3)CCN2[C@@H](C(NC)=O)C4=CC=CC=C4

Sinonimi:

• (R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-N-Methyl-2-Phenylacetamide
• (αR,1S)-3,4-Dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-isoquinolineacetamide
• 2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-, (αR,1S)-
• Act-078573
• Act-078573(R)-2-((R)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• Almorexant
• AlMorexant (hydrochloride)
• CS-1665
• almorexant (ACT-078573), CID 23727689
• ACT-078573;ACT 078573;ACT078573
• (2R)-2-((1S)-6,7-Dimethoxy-1-{2-(4-(trifluoromethyl)phenyl)ethyl}-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• almorexant (ACT-078573)
• 2-(6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• (2R)-2-[(1S)-6,7-DIMETHOXY-1-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-N-METHYL-2-PHENYLACETAMIDE
• Almorexant [inn]
• AlMorexant HCl

Almorexant

CAS: 871224-64-5

Almorexant

Purezza: ≥95%

Peso molecolare: 512.56g/mol

Ref: 54-BUP03376

Almorexant-13C-d3

CAS: 871224-64-5

Formula: C₂₈₁₃CH₂₈D₃F₃N₂O₃

Colore e forma: Pale Yellow Solid

Peso molecolare: 516.58

Ref: 4Z-A-201002

Almorexant

CAS: 871224-64-5

Formula: C₂₉H₃₁F₃N₂O₃

Colore e forma: Pale Yellow Solid

Peso molecolare: 512.58

Ref: 4Z-A-201001

Almorexant

CAS: 871224-64-5

Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.

Formula: C₂₉H₃₁F₃N₂O₃

Purezza: 97.75% - 98.02%

Colore e forma: Solid

Peso molecolare: 512.56

Ref: TM-T2613

Almorexant

CAS: 871224-64-5

Formula: C₂₉H₃₁F₃N₂O₃

Peso molecolare: 512.58

Ref: ST-EA-CP-A313002

Almorexant

CAS: 871224-64-5

Almorexant is a pharmacological agent that is used to treat insomnia. It is an orexin receptor antagonist and has been approved for the treatment of chronic insomnia in adults. Almorexant binds to the α1 subunit of the orexin receptors, which are located in the hypothalamus and have been shown to be involved in energy metabolism, locomotor activity, and sleep regulation. This drug inhibits neuronal excitation by blocking these receptors and can reduce wakefulness-promoting signaling. In humans, almorexant has been shown to produce a concentration-dependent decrease in wakefulness and increased sleep time when given at doses of 0.5mg or 1mg. Almorexant also has a significant effect on locomotor activity in animals with no effect on energy metabolism or body temperature.

Formula: C₂₉H₃₁F₃N₂O₃

Purezza: Min. 95%

Peso molecolare: 512.56 g/mol

Ref: 3D-FA103508