CAS 873857-62-6

Fidaxomicina

Descrizione:

Fidaxomicina è un antibiotico macrolide utilizzato principalmente per il trattamento delle infezioni da Clostridium difficile. È caratterizzato dal suo meccanismo d'azione unico, che implica l'inibizione della RNA polimerasi batterica, impedendo così la sintesi proteica batterica. Questa inibizione selettiva consente a Fidaxomicina di colpire efficacemente C. difficile risparmiando la flora intestinale normale, fondamentale per mantenere la salute intestinale. Il composto è scarsamente assorbito a livello sistemico, portando a elevate concentrazioni nel tratto gastrointestinale, il che ne aumenta l'efficacia contro le infezioni intestinali. Fidaxomicina viene tipicamente somministrato per via orale ed è noto per il suo profilo di sicurezza favorevole, con meno effetti collaterali gastrointestinali rispetto ad altri antibiotici. La sua struttura chimica presenta un complesso anello di lattone macrociclico, che contribuisce alle sue proprietà antibatteriche. Il farmaco è spesso preferito nei casi di infezioni ricorrenti da C. difficile grazie alla sua capacità di ridurre i tassi di recidiva. In generale, Fidaxomicina rappresenta un significativo progresso nel trattamento della diarrea associata agli antibiotici causata da C. difficile, offrendo un approccio mirato con una minima interruzione del microbioma intestinale.

Formula: C₅₂H₇₄Cl₂O₁₈

InChI: InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-22,24,28-30,33-34,40-46,50-51,55-61H,13-14,18,20,23H2,1-12H3/b16-15+,25-19+,26-22+,27-21+,31-17+/t28-,29-,30+,33+,34+,40-,41+,42+,43+,44-,45+,46+,50-,51-/m1/s1

InChI key: InChIKey=ZVGNESXIJDCBKN-UUEYKCAUSA-N

SMILES: C(O[C@H]1[C@H](O)[C@H](OC)[C@H](OC\C=2\C(=O)O[C@]([C@@H](C)O)(C/C=C(\C)/C=C(\C)/[C@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C)C)=O)C(C)(C)O3)[C@@H](CC)/C=C(\C)/[C@@H](O)C\C=C\C2)[H])O[C@@H]1C)(=O)C4=C(CC)C(Cl)=C(O)C(Cl)=C4O

Sinonimi:

• (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
• Clostomicin B₁
• Dificid
• Dificlir
• Fidaxomycin
• Lipiarmicin
• Lipiarmycin
• Lipiarmycin A 3
• Opt-80
• Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-<span class="text-smallcaps">D</smallcap>-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-<smallcap>D</span>-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
• Par 01
• Par-101
• R-Tiacumicin B
• Tiacumicin B
• (3E,5E,8S,9E,11S,12R,13E,15E,18S)-3-[[[6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaen-2-one
• Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-

Fidaxomicin

CAS: 873857-62-6

Formula: C₅₂H₇₄Cl₂O₁₈

Purezza: >98.0%(HPLC)

Colore e forma: White to Light yellow powder to crystal

Peso molecolare: 1,058.05

Ref: 3B-F1216

Fidaxomycin; Lipiarmycin A3; Tiacumicin B; Chlostomicin B1;

CAS: 873857-62-6

Formula: C₅₂H₇₄CL₂O₁₈

Purezza: 98.89%

Colore e forma: Off white. Powder

Peso molecolare: 1056.0

Ref: 8R-CL0228

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin

Formula: C₅₂H₇₄Cl₂O₁₇

Purezza: By hplc: 98.48% (Typical Value in Batch COA)

Colore e forma: white to off-white powder

Peso molecolare: 1,042.04g/mol

Ref: 54-BIW4203

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin

Purezza: ≥98%

Peso molecolare: 1058.04g/mol

Ref: 54-BUP15040

Fidaxomicin

CAS: 873857-62-6

Formula: C₅₂H₇₄Cl₂O₁₈

Purezza: ≥ 97.0%

Colore e forma: White to off-white powder

Peso molecolare: 1058.0

Ref: 7W-GA3227

Fidaxomicin

CAS: 873857-62-6

Formula: C₅₂H₇₄Cl₂O₁₈

Colore e forma: White To Off-White Solid

Peso molecolare: 1058.05

Ref: 4Z-F-076001

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults.

Formula: C₅₂H₇₄Cl₂O₁₈

Purezza: 99.76% - 99.82%

Colore e forma: Solid

Peso molecolare: 1058.04

Ref: TM-T6194

Fidaxomicin

CAS: 873857-62-6

Applications Fidaxomicin is a nonabsorbed macrocyclic antibiotic, and is the first antimicrobial to be approved by the FDA for the treatment of Clostridium difficile infection (CDI) in 20 years. Fidaxomicin works by inhibiting sporulation by CDI, sustaining clinical response and reducing recurrences of this pathogen.
References Babakhani, F., et al.: Clin. Infect. Dis., 55, S162 (2012); Venugopal, A., et al.: Clin. Infect. Dis., 54, 568 (2012)

Formula: C₅₂H₇₄Cl₂O₁₈

Colore e forma: Neat

Peso molecolare: 1058.04

Ref: TR-F335400

Fidaxomicin

CAS: 873857-62-6

Fidaxomicin is a macrocyclic antibiotic with action on bacterial RNA polymerase and is used for treating Clostridium difficile infections.

Formula: C₅₂H₇₄Cl₂O₁₈

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 1,058.04 g/mol

Ref: 3D-AF31015