CAS 877399-52-5

Crizotinib

Descrizione:

Crizotinib è un inibitore della tirosina chinasi a piccole molecole utilizzato principalmente nel trattamento di alcuni tipi di carcinoma polmonare non a piccole cellule (NSCLC) che presentano specifiche mutazioni genetiche, come riarrangiamenti di ALK (chinasi del linfoma anaplastico) e alterazioni del gene ROS1. La sua formula chimica è C21H22Cl2N4O2 e presenta una struttura complessa che include un nucleo biciclico. Crizotinib agisce inibendo selettivamente l'attività delle chinasi ALK e ROS1, interrompendo così le vie di segnalazione che promuovono la crescita e la sopravvivenza del tumore. La sostanza viene tipicamente somministrata per via orale ed è nota per la sua capacità di penetrare la barriera ematoencefalica, rendendola efficace contro le metastasi cerebrali. Gli effetti collaterali comuni possono includere nausea, diarrea e disturbi visivi. Grazie al suo meccanismo d'azione mirato, Crizotinib rappresenta un significativo progresso nella terapia personalizzata contro il cancro, consentendo opzioni di trattamento più efficaci basate sul profilo molecolare del tumore. Come per qualsiasi farmaco, il suo utilizzo deve essere guidato da un professionista sanitario, considerando possibili interazioni e controindicazioni.

Formula: C₂₁H₂₂Cl₂FN₅O

InChI: InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChI key: InChIKey=KTEIFNKAUNYNJU-GFCCVEGCSA-N

SMILES: O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N

Sinonimi:

• (5-(Pyridin-3-Yl)-1,3,4-Oxadiazol-2-Yl)Methanamine
• (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine
• 2-Pyridinamine, 3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]-5-[1-(4-Piperidinyl)-1H-Pyrazol-4-Yl]-
• 3-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
• 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine
• 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
• Crizotinib
• Pf 2341066
• Pf-02341066
• Pf2341066
• Xalkori
• [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine
• 3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
• (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
• [3-[[(R)-1-(2,6-Dichloro-3-
• 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine
• PF-2341066/Crizotinib
• k-ras(g12c) inhibitor 6 NA
• fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]aMine
• Crozotinib
• 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-aMinopyridine
• Crizotinib (PF2341066)
• PF-02341066 Crizotinib

3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine

CAS: 877399-52-5

Formula: C₂₁H₂₂Cl₂FN₅O

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 450.3367

Ref: IN-DA0036BC

Crizotinib

CAS: 877399-52-5

Crizotinib

Purezza: ≥98%

Peso molecolare: 450.34g/mol

Ref: 54-BUP15747

Crizotinib

CAS: 877399-52-5

Formula: C₂₁H₂₂Cl₂FN₅O

Colore e forma: White To Off-White Solid

Peso molecolare: 450.34

Ref: 4Z-C-123001

(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

CAS: 877399-52-5

(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

Formula: C₂₁H₂₂Cl₂FN₅O

Purezza: 95%

Colore e forma: white to brown solid

Peso molecolare: 450.34g/mol

Ref: 54-PC402134

Crizotinib

CAS: 877399-52-5

Colore e forma: Neat

Ref: 86-MM3930.00

Crizotinib

CAS: 877399-52-5

Formula: C₂₁H₂₂Cl₂FN₅O

Purezza: ≥ 98.0%

Colore e forma: White to off-white powder

Peso molecolare: 450.34

Ref: 7W-GW2561

Crizotinib

CAS: 877399-52-5

Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.

Formula: C₂₁H₂₂Cl₂FN₅O

Purezza: 99% - 99.87%

Colore e forma: Solid

Peso molecolare: 450.34

Ref: TM-T1661

Crizotinib

CAS: 877399-52-5

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 450.339996337891

Ref: 10-F793129

Crizotinib

CAS: 877399-52-5

Inhibits receptor tyrosine kinases c-MET and ALK; antineoplastic

Formula: C₂₁H₂₂Cl₂FN₅O

Purezza: Min. 98 Area-%

Colore e forma: Powder

Peso molecolare: 450.34 g/mol

Ref: 3D-FD20585

Crizotinib - Bio-X ™

CAS: 877399-52-5

Crizotinib is a drug that belongs to the group of tyrosine kinase inhibitors. It is used in the treatment of cancers, including non-small cell lung cancer, small cell lung cancer, and other types of solid tumours. Crizotinib inhibits the activity of the tyrosine kinase ALK or anaplastic lymphoma kinase, which is involved in many signalling pathways and biological processes. The inhibition of this enzyme leads to decreased energy metabolism, reduced mitochondrial membrane potential and increased susceptibility to apoptosis.

Formula: C₂₁H₂₂Cl₂FN₅O

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 450.34 g/mol

Ref: 3D-BC164334