CAS 88321-09-9

Loxistatina

Descrizione:

Loxistatina, con il numero CAS 88321-09-9, è un composto sintetico principalmente noto per il suo ruolo come potente inibitore dell'enzima HMG-CoA reduttasi, che è cruciale nella via di biosintesi del colesterolo. Questa caratteristica posiziona Loxistatina come un potenziale agente terapeutico nella gestione dell'iperlipidemia e delle condizioni cardiovascolari correlate. Il composto presenta una specifica struttura chimica che contribuisce alla sua attività biologica, tipicamente caratterizzata da un anello di lattone e vari gruppi funzionali che migliorano la sua interazione con l'enzima target. Loxistatina è stato studiato per le sue proprietà farmacocinetiche, inclusi assorbimento, distribuzione, metabolismo ed escrezione, che sono essenziali per comprendere la sua efficacia e il profilo di sicurezza. Inoltre, come altre statine, potrebbe avere effetti pleiotropici, influenzando potenzialmente l'infiammazione e la funzione endoteliale. Tuttavia, come con qualsiasi agente farmaceutico, l'uso di Loxistatina potrebbe essere associato a effetti collaterali, richiedendo una considerazione attenta nelle applicazioni cliniche. Ulteriori ricerche continuano a esplorare il suo pieno potenziale terapeutico e i meccanismi d'azione.

Formula: C₁₇H₃₀N₂O₅

InChI: InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChI key: InChIKey=SRVFFFJZQVENJC-IHRRRGAJSA-N

SMILES: C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(OCC)=O)O1

Sinonimi:

• 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
• Aloxistatin
• E 64c ethyl ester
• E-64d
• E64d
• E64d/pepstatin
• EST
• EST (pharmaceutical)
• Ep 453
• Loxistatin
• NSC 694281
• Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-
• Pepstatin E64d
• ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate

L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

CAS: 88321-09-9

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer’s disease animal models.

Formula: C₁₇H₃₀N₂O₅

Purezza: > 99%

Colore e forma: White

Peso molecolare: 342.44

Ref: 01-4027911

2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-

CAS: 88321-09-9

Formula: C₁₇H₃₀N₂O₅

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 342.4305

Ref: IN-DA0048C1

Aloxistatin

CAS: 88321-09-9

Aloxistatin

Purezza: ≥98%

Peso molecolare: 342.43g/mol

Ref: 54-BUP15070

E-64d [for Biochemical Research]

CAS: 88321-09-9

Formula: C₁₇H₃₀N₂O₅

Purezza: >95.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 342.44

Ref: 3B-E1337

E-64d protease inhibitor

CAS: 88321-09-9

Formula: C₁₇H₃₀N₂O₅

Purezza: ≥ 95.0%

Colore e forma: White powder

Peso molecolare: 342.43

Ref: 7W-GL9790

E-64d

CAS: 88321-09-9

E-64d

Formula: C₁₇H₃₀N₂O₅

Purezza: 98.8% (hplc) (Typical Value in Batch COA)

Colore e forma: Powder

Peso molecolare: 342.43g/mol

Ref: 54-BIE1005

Aloxistatin

CAS: 88321-09-9

Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.

Formula: C₁₇H₃₀N₂O₅

Purezza: 99.46% - 99.69%

Colore e forma: Solid

Peso molecolare: 342.43

Ref: TM-T6040

E-64d

Prodotto controllato

CAS: 88321-09-9

Applications E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.
References Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);

Formula: C₁₇H₃₀N₂O₅

Colore e forma: Neat

Peso molecolare: 342.43

Ref: TR-E100500

(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester

CAS: 88321-09-9

Inhibitor of cathepsins

Formula: C₁₇H₃₀N₂O₅

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 342.43 g/mol

Ref: 3D-FE29623

E-64-d

CAS: 88321-09-9

E-64-d is a research tool that is used in cell biology, pharmacology, and biochemistry to study protein interactions. E-64-d is an activator, ligand, or receptor for ion channels and has been shown to inhibit the activity of high purity K+ channels. This peptide binds to the extracellular loop of voltage-gated potassium channels (Kv1.2) and inhibits the opening of these channels by blocking their access to ATP. E-64-d also binds to an antibody as a competitive inhibitor of the antigen binding site on the antibody.

Formula: C₁₇H₃₀N₂O₅

Purezza: Min. 95%

Peso molecolare: 342.43 g/mol

Ref: 3D-IED-4321-V

L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER

CAS: 88321-09-9

Purezza: 95.0%

Peso molecolare: 342.4360046386719

Ref: 10-F475468