CAS 88937-61-5

Z-Arg-Arg-AMC

Descrizione:

Z-Arg-Arg-AMC, noto anche con il suo numero CAS 88937-61-5, è un substrato peptidico sintetico comunemente utilizzato nella ricerca biochimica, in particolare negli studi che coinvolgono proteasi e attività enzimatica. Questo composto presenta un gruppo protettivo Z (benzyloxycarbonile) sul residuo di arginina N-terminale, che ne migliora stabilità e solubilità. La presenza di due residui di arginina nella sua struttura lo rende un substrato per vari enzimi, in particolare quelli che scindono aminoacidi basici. Il moiety AMC (7-amino-4-metilcoumarina) funge da reporter fluorescente, consentendo la quantificazione dell'attività enzimatica attraverso misurazioni di fluorescenza. Z-Arg-Arg-AMC è spesso utilizzato in saggi per studiare l'attività proteolitica, fornendo informazioni sulla cinetica enzimatica e sulla specificità del substrato. Le sue caratteristiche includono alta solubilità in soluzioni acquose, stabilità in condizioni fisiologiche e la capacità di produrre un segnale fluorescente misurabile dopo la scissione, rendendolo uno strumento prezioso nella ricerca di biologia molecolare e biochimica.

Formula: C₃₀H₃₉N₉O₆

InChI: InChI=1/C30H39N9O6/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-22(9-5-13-35-28(31)32)26(41)39-27(42)23(10-6-14-36-29(33)34)38-30(43)44-17-19-7-3-2-4-8-19/h2-4,7-8,11-12,15-16,22-23,37H,5-6,9-10,13-14,17H2,1H3,(H,38,43)(H4,31,32,35)(H4,33,34,36)(H,39,41,42)/t22-,23-/m0/s1

InChI key: InChIKey=DLELKZFCVLJXKZ-GOTSBHOMSA-N

SMILES: CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC(OCC3=CC=CC=C3)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1

Sinonimi:

• Z-Arg-Arg-AMC
• Benzyloxycarbonyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide
• 386: PN: US20220178935 SEQID: 1064 claimed sequence
• N2-[(Phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
• L-Argininamide, N2-[(phenylmethoxy)carbonyl]-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Z-Arg-Arg-NHMec
• Z-ARG-ARG-MCA(HYDROCHLORIDE FORM)
• Z-ARG-ARG-MCA HYDROCHLORIDE
• BENZYLOXYCARBONYL-L-ARGINYL-L-ARGININE 4-METHYLCOUMARYL-7-AMIDE HYDROCHLORIDE
• benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]amino]-1-oxopentan-2-yl]carbamate
• N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ARG-ARG-AMC HYDROCHLORIDE SALT
• benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-RR-AMC, an excellent, specific substrate for cathepsin B, an enzyme found in secretory vesicles. Cathepsin B has been identified as a β-secretase, as such it is involved in β-amyloid production. Z-RR-AMC is a convenient fluorogenic substrate for stem bromelain, as it is scarcely affected by fruit bromelain.

Formula: C₃₀H₃₉N₉O₆

Purezza: > 98%

Colore e forma: White Powder

Peso molecolare: 621.7

Ref: 01-4004789

Z-Arg-Arg-AMC hydrochloride salt

CAS: 88937-61-5

Z-Arg-Arg-AMC hydrochloride salt is a versatile compound that acts as a catalyst and forms strong hydrogen bonds. It exhibits proteolytic activity and has been found to be effective in breaking down proteins. In addition, Z-Arg-Arg-AMC hydrochloride salt has been shown to possess neuroprotective properties, making it a potential candidate for the treatment of neurological disorders. It also demonstrates anthelmintic activity, which means it can be used to combat parasitic worm infections. Furthermore, this compound has antioxidant activity and can help reduce lipid peroxidation, protecting cells from oxidative damage. With its diverse range of characteristics, Z-Arg-Arg-AMC hydrochloride salt holds great promise in various research fields such as biochemistry and medicine.

Formula: C₃₀H₃₉N₉O₆·xHCl

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 621.69 g/mol

Ref: 3D-FA110491

Z-Arg-Arg-AMC

CAS: 88937-61-5

Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.

Formula: C₃₀H₃₉N₉O₆

Purezza: Min. 95%

Peso molecolare: 621.69 g/mol

Ref: 3D-MRR-3123-V