CAS 89-25-8

Edaravone

Descrizione:

Edaravone, con il numero CAS 89-25-8, è un composto sintetico riconosciuto principalmente per le sue proprietà neuroprotettive. È classificato come un catturatore di radicali liberi, il che significa che può neutralizzare i radicali liberi dannosi nel corpo, riducendo così lo stress ossidativo. Questa caratteristica lo rende particolarmente rilevante nel trattamento delle malattie neurodegenerative, come la sclerosi laterale amiotrofica (SLA) e l'ictus ischemico acuto. Edaravone è tipicamente presentato come un liquido incolore o giallo pallido ed è solubile in acqua, il che facilita la sua somministrazione in contesti clinici. Il composto ha un peso molecolare relativamente basso e presenta un livello moderato di lipofilia, consentendogli di penetrare efficacemente nelle membrane biologiche. Il suo meccanismo d'azione implica l'inibizione della perossidazione lipidica e la protezione delle cellule neuronali dai danni ossidativi. Edaravone è stato studiato ampiamente per il suo potenziale terapeutico e, sebbene sia generalmente ben tollerato, può avere effetti collaterali che richiedono monitoraggio durante il trattamento.

Formula: C₁₀H₁₀N₂O

InChI: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChI key: InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N

SMILES: O=C1N(N=C(C)C1)C2=CC=CC=C2

Sinonimi:

• 1,3,5-Pmp
• 1-Fenil-3-Metil-5-Pirazolona
• 1-Phenyl-3-Methyl-5-Prazalone
• 1-Phenyl-3-Methyl-5-Pyrazole
• 1-Phenyl-3-Methyl-5-Pyrazolone
• 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
• 1-Phenyl-3-methyl-2-pyrazolin-5-one
• 1-Phenyl-3-methyl-5-oxopyrazole
• 1-Phenyl-3-methyl-5-pyrazolinone
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-On
• 2,4-Dihydro-5-Methyl-2-Phenyl-3H-Pyrazol-3-One
• 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazole-3-one
• 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
• 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one
• 3-Methyl-1-phenyl-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-2-pyrazoline-5-one
• 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazol-5-one
• 3-Methyl-1-phenyl-4,5-dihydropyrazole-5-one
• 3-Methyl-1-phenyl-5-pyrazolon
• 3-Methyl-1-phenyl-5-pyrazolone
• 3-Methyl-1-phenylpyrazol-5(4H)-one
• 3-Methyl-1-phenylpyrazol-5-one
• 3-Methyl-1-phenylpyrazole-5-one
• 3-Methyl-1-phenylpyrazolin-5-one
• 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
• 4,5-Dihydro-3-methyl-5-oxo-1-phenylpyrazole
• 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
• 5-Methyl-2-phenyl-2,4-dihydropyrazol-3-one
• 5-Methyl-2-phenyl-2H-pyrazol-3(4H)-one
• 5-Methyl-2-phenylpyrazol-3-one
• Developer Z
• Edarabone
• Edaravon
• Edaravone
• Edvaradone
• Mci-186
• Methylphenylpyrazolone
• Nci-C 03952
• Norantipyrine
• Norphenazone
• Nsc 12
• Nsc 26139
• Nsc 2629
• PMP
• Phenylmethyl pyrazolone
• Pyrazolin(2)-5-One, 3-Methyl-1-Phenyl-
• Radicava
• Radicut
• C.I. Developer 1

3-Methyl-1-phenyl-5-pyrazolone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purezza: >98.0%(T)(HPLC)

Colore e forma: White to Orange to Green powder to crystal

Peso molecolare: 174.20

Ref: 3B-M0687

3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%

CAS: 89-25-8

3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original A

Formula: C₁₀H₁₀N₂O

Purezza: 98+%

Colore e forma: Pale cream to cream to yellow to pale brown, Powder

Peso molecolare: 174.20

Ref: 02-A11161

PHENAZONE IMPURITY A CRS

CAS: 89-25-8

PHENAZONE IMPURITY A CRS

Ref: 41-Y0001138

Antipyrine Related Compound A (3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one)

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Formula: C₁₀H₁₀N₂O

Colore e forma: White Pale Yellow Powder

Peso molecolare: 174.07931

Ref: 45-1040016

Edaravone

CAS: 89-25-8

Edaravone (MCI-186)(MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

Formula: C₁₀H₁₀N₂O

Purezza: 99.44% - >99.99%

Colore e forma: Pale Yellow Solid Solid Particulate/Powder

Peso molecolare: 174.20

Ref: TM-T0407

Edaravone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 174.1992

Ref: IN-DA0087X2

Edaravone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Colore e forma: White To Off-White Solid

Peso molecolare: 174.20

Ref: 4Z-E-531

Edaravone

CAS: 89-25-8

Edaravone

Purezza: ≥98%

Peso molecolare: 174.2g/mol

Ref: 54-BUP18301

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

1-Phenyl-3-methyl-5-pyrazolone

Formula: C₁₀H₁₀N₂O

Purezza: 98%

Colore e forma: yellow crystalline powder

Peso molecolare: 174.20g/mol

Ref: 54-BIP1205

1-Phenyl-3-methyl-5-pyrazolone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purezza: ≥ 98.0%

Colore e forma: White to yellow to brown powder or crystals

Peso molecolare: 174.20

Ref: 7W-GK3502

5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (Edaravone)

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Colore e forma: Neat

Peso molecolare: 174.20

Ref: 86-MM0036.01

Edaravone

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Colore e forma: Neat

Peso molecolare: 174.20

Ref: 04-C13105000

3-​Methyl-​1-​phenyl-​2-​pyrazolin-​5-​one(Edaravone)

Prodotto controllato

CAS: 89-25-8

Impurity Phenazone EP Impurity A
Applications Edaravone inhibits the disease activity in rheumatoid arthritis. Edaravone can significantly enhance IR flap viability and protect flap vessels, which is related to scavenging oxygen free radicals, reducing the consumption of SOD, reducing the extent of lipid peroxidation and inflammation, and protecting functional structure of vessels in the early stages of reperfusion. It also shows protective effects against STZ-induced cognitive impairment, oxidative stress, cholinergic dysfunction and altered protein expressions. Its acts like a free radical scavenger, decreased apoptotic cell death, oxidative damage to DNA and lipids, and angiogenesis through inhibiting JNK and p38 MAPK pathways in AMD, glaucoma, DR, and RVO animal models.
References Reeta KH et al. Eur J Neurosci. 2017 Feb 15Masuda T et al. Oxid Med Cell Longev. 2017;2017:9208489Zhang DY et al. J Huazhong Univ Sci Technolog Med Sci. 2017 Feb;37(1):51-56Criswell LA et al. Am J Med. 2002 Apr 15;112(6):465-71.

Formula: C₁₀H₁₀N₂O

Colore e forma: Neat

Peso molecolare: 174.20

Ref: TR-E335000

Antipyrine USP Related Compound A

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Peso molecolare: 174.2

Ref: ST-EA-CP-A104005

3-Methyl-1-phenyl-2-pyrazoline-5-one

CAS: 89-25-8

Formula: C₁₀H₁₀N₂O

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 174.203

Ref: 10-F038216

Edaravone

CAS: 89-25-8

Edaravone is a drug that belongs to the class of radical scavengers and has been shown to be effective in reducing neuronal death by blocking the mitochondrial permeability transition pore. It also protects against oxidative injury by inhibiting lipid peroxidation, protein nitration, and DNA damage. Edaravone has been shown to be effective in treating bowel disease and possibly other inflammatory diseases such as sepsis. Edaravone is injected intravenously and can be used as an injection solution with dextran sulfate due to its low solubility in water. Edaravone binds reversibly to the toll-like receptor 4 (TLR4) and inhibits TLR4-mediated signaling pathways, which may lead to a reduction of inflammation.

Formula: C₁₀H₁₀N₂O

Purezza: Min. 98%

Colore e forma: Powder

Peso molecolare: 174.2 g/mol

Ref: 3D-FE22642

Edaravone

CAS: 89-25-8

Aromatic or modified aromatic compounds containg an unfused pyrazolering (whether or not hydrogenated) in the structure

Formula: C₁₀H₁₀N₂O

Peso molecolare: 174.07931

Ref: 45-1231900