CAS 90614-49-6

L-Valil-L-prolil-L-leucina

Descrizione:

L-Valil-L-prolil-L-leucina, con il numero CAS 90614-49-6, è un tripeptide composto da tre aminoacidi: valina, prolina e leucina. Questo composto è caratterizzato dalla sua sequenza specifica, che influisce sulle sue proprietà strutturali e funzionali. Come peptide, presenta caratteristiche tipiche degli aminoacidi, inclusa la capacità di formare legami idrogeno e partecipare a varie interazioni biochimiche. La presenza di prolina, nota per la sua unica struttura ciclica, può conferire rigidità alla catena peptidica, influenzando la sua conformazione e stabilità. L-Valil-L-prolil-L-leucina può svolgere un ruolo nei processi biologici, influenzando potenzialmente il ripiegamento delle proteine, l'attività enzimatica o le vie di segnalazione cellulare. Inoltre, peptidi come questo sono spesso studiati per le loro potenziali applicazioni terapeutiche, inclusi i loro ruoli nella progettazione e nello sviluppo di farmaci. La sua solubilità, stabilità e reattività possono variare in base alle condizioni ambientali come pH e temperatura, rendendolo un argomento di interesse sia nella ricerca biochimica che nelle formulazioni farmaceutiche.

Formula: C₁₆H₂₉N₃O₄

InChI: InChI=1/C16H29N3O4/c1-9(2)8-11(16(22)23)18-14(20)12-6-5-7-19(12)15(21)13(17)10(3)4/h9-13H,5-8,17H2,1-4H3,(H,18,20)(H,22,23)

InChI key: InChIKey=NHXZRXLFOBFMDM-AVGNSLFASA-N

SMILES: C([C@H](C(C)C)N)(=O)N1[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC1

Sinonimi:

• 468: PN: WO2005081628 SEQID: 470 claimed protein
• <span class="text-smallcaps">L</smallcap>-Leucine, <smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-(1-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl)-
• <span class="text-smallcaps">L</smallcap>-Valyl-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-leucine
• H-Val-Pro-Leu-OH
• L-valyl-L-prolyl-L-leucine
• Valylprolylleucine
• Diprotin B
• L-Leucine, L-valyl-L-prolyl-
• L-Leucine, N-(1-L-valyl-L-prolyl)-
• (-)-L-Val-L-Pro-L-Leu-OH
• L-VALYL-L-PROLYL LEUCINE
• VAL-PRO-LEU
• n-(1-l-valyl-l-prolyl)-l-leucin
• Val-Pro-Leu-OH
• 2-[[1-(2-amino-3-methylbutanoyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoic acid

L-Leucine, L-valyl-L-prolyl-

CAS: 90614-49-6

Formula: C₁₆H₂₉N₃O₄

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 327.4192

Ref: IN-DA00IG8H

Diprotin B

CAS: 90614-49-6

Diprotin B

Purezza: 98%

Peso molecolare: 327.42g/mol

Ref: 54-OR1035879

Diprotin B

CAS: 90614-49-6

Formula: C₁₆H₂₉N₃O₄

Peso molecolare: 327.40

Ref: 7W-GA4837

Diprotin B

CAS: 90614-49-6

Diprotin B is a dipeptidyl peptidase IV inhibitor.

Formula: C₁₆H₂₉N₃O₄

Purezza: 98%

Colore e forma: White Lyophilized Powder

Peso molecolare: 327.42

Ref: TM-T25341

Diprotin B

CAS: 90614-49-6

Diprotin B is a peptide that is the most potent inhibitor of serine proteases identified to date. It has been shown to inhibit both chymotrypsin and trypsin, with an IC50 value of 0.5 nM for chymotrypsin and 2 nM for trypsin. Diprotin B is able to inhibit the enzymatic activity by protonation at the catalytic residue, S2, in the active site of serine proteases. The efficiency of this inhibition can be increased by altering pH or adding proton donors such as HCl or NaOH. This peptide also hydrolyzes at a slower rate than the substrate (chymotrypsin). Diprotin B has a molecular weight of 906 Da and contains two amino acids: valine (Val) and leucine (Leu). It contains no functional groups that would be expected to affect its inhibitory properties.

Formula: C₁₆H₂₉N₃O₄

Purezza: Min. 95%

Peso molecolare: 327.42 g/mol

Ref: 3D-FD109478

Diprotin B

CAS: 90614-49-6

Diprotin B is a colony-stimulating factor protein that has inhibitory properties in the colon. It has been shown to be effective in reducing symptoms of bowel disease and inflammatory bowel disease, as well as reducing the recurrence of colon cancer. Diprotin B inhibits the release of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The inhibition of these proinflammatory cytokines may contribute to the anti-inflammatory effects observed with Diprotin B treatment. Diprotin B also prevents cytosolic calcium accumulation, which can lead to cell lysis. This process is mediated by antimicrobial peptides called defensins that are expressed in Paneth cells found in the small intestine and colon. Defensins have also been shown to induce cell lysis through their ability to bind to bacterial membranes.

Formula: C₁₆H₂₉N₃O₄

Purezza: Min. 95%

Peso molecolare: 327.43 g/mol

Ref: 3D-IDB-3982-PI