CAS 9076-44-2

Chimostatina

Descrizione:

Chimostatina è un inibitore potente e selettivo delle serina proteasi, mirato in particolare alla quimotripsina e alle enzimi correlate. È un prodotto naturale derivato dalla fermentazione di alcuni actinobatteri, in particolare delle specie di Streptomyces. Chimostatina presenta una struttura unica che gli consente di legarsi efficacemente al sito attivo delle serina proteasi, impedendo così l'accesso al substrato e inibendo l'attività enzimatica. Questa caratteristica lo rende uno strumento prezioso nella ricerca biochimica per studiare le funzioni e i meccanismi delle proteasi. Inoltre, Chimostatina è stato studiato per le sue potenziali applicazioni terapeutiche, in particolare nella ricerca sul cancro, grazie alla sua capacità di modulare i processi proteolitici coinvolti nella progressione tumorale e nella metastasi. Il composto è tipicamente utilizzato in ambienti di laboratorio e la sua efficacia può variare in base alla specifica proteasi studiata. Come per molti inibitori delle proteasi, è essenziale considerare attentamente la concentrazione e le condizioni sperimentali per risultati ottimali nelle applicazioni di ricerca.

Formula: Unspecified

InChI: InChI=1/2C31H41N7O6.C30H39N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21;1-3-19(2)25(27(40)34-22(18-39)16-20-10-6-4-7-11-20)37-28(41)26(23-14-15-33-30(32)35-23)38-31(44)36-24(29(42)43)17-21-12-8-5-9-13-21;1-18(2)24(26(39)33-21(17-38)15-19-9-5-3-6-10-19)36-27(40)25(22-13-14-32-29(31)34-22)37-30(43)35-23(28(41)42)16-20-11-7-4-8-12-20/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44);4-13,18-19,22-26H,3,14-17H2,1-2H3,(H,34,40)(H,37,41)(H,42,43)(H3,32,33,35)(H2,36,38,44);3-12,17-18,21-25H,13-16H2,1-2H3,(H,33,39)(H,36,40)(H,41,42)(H3,31,32,34)(H2,35,37,43)/t22-,23?,24-,25-,26-;19-,22-,23?,24-,25-,26-;21-,22?,23-,24-,25-/m000/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC[C@H](C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC(C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O

Sinonimi:

• Chymostatin
• N-{[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-{[(2S)-4-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}pentan-2-yl]amino}-2-oxoethyl]carbamoyl}-L-phenylalanine
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S,2S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
• (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid

Chymostatin

CAS: 9076-44-2

For research use

Colore e forma: White to off-white, Powder

Ref: 02-J63275

Chymostatin (microbial product)

CAS: 9076-44-2

The microbial product is a mixture of the chymostatins A, B, and C. It inhibits most cysteine proteases, especially chymotrypsin. Chymostatin is often applied for inhibiting chymase.

Colore e forma: White Powder

Ref: 01-4030514

Chymostatin

CAS: 9076-44-2

Formula: C₃₁H₄₁N₇O₆

Peso molecolare: 604.90

Ref: 7W-GP4687

Chymostatin

CAS: 9076-44-2

Chymostatin is a protein that inhibits the polymerase chain reaction (PCR) by binding to the DNA polymerase. It has been shown to have a hypoglycemic effect in mice with myocardial infarcts and can also induce apoptosis in inflammatory lesions. Chymostatin binds to intracellular targets, such as cell factor and pro-apoptotic protein, which are involved in energy metabolism and inflammatory lesion. The inhibition of these targets may be due to its chemical biology properties, which include the formation of disulfide bonds and basic proteins. Chymostatin is not active against bacterial cells but can inhibit enzyme activities in mammalian cells.

Formula: C₃₁H₄₂N₆O₇

Purezza: Min. 95%

Peso molecolare: 610.71 g/mol

Ref: 3D-ICY-4063

Chymostatin

CAS: 9076-44-2

Inhibitor of chymotrypsin

Formula: C₃₁H₄₁N₇O₆

Colore e forma: White To Yellowish Solid

Peso molecolare: 607.7 g/mol

Ref: 3D-FC29634

Chymostatin (0.5 mg vial)

CAS: 9076-44-2

Chymostatin is a protein-based inhibitor that binds to the receptor site of amyloid beta peptides, preventing them from aggregating and thereby inhibiting the formation of amyloid plaques. It has been shown that chymostatin inhibits ion channels, ligand-gated channels, and voltage-gated channels. Chymostatin is a high purity product with an average purity of 99% by HPLC analysis. It is also available in a variety of concentrations (0.5 mg vial).

Formula: C₃₁H₄₂N₆O₇

Purezza: Min. 95%

Peso molecolare: 610.72 g/mol

Ref: 3D-ICY-4063-V

Chymostatin

CAS: 9076-44-2

Formula: C₃₁H₄₁N₇O₆

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 607.7005400000002

Ref: IN-DA00ILR4