CAS 90954-53-3

peptide correlato al gene della calcitonina umano

Descrizione:

Il peptide correlato al gene della calcitonina (CGRP) è un neuropeptide che svolge un ruolo significativo in vari processi fisiologici, in particolare nel sistema nervoso e nella regolazione cardiovascolare. Deriva dal gene della calcitonina ed è principalmente coinvolto nella vasodilatazione e nella trasmissione dei segnali di dolore. Il CGRP è composto da una sequenza di aminoacidi, rendendolo un peptide, ed esiste in due isoforme: alfa e beta, con la forma alfa predominante negli esseri umani. Il peptide è noto per i suoi potenti effetti vasodilatatori, che contribuiscono al suo ruolo nella fisiopatologia dell'emicrania. Il CGRP è anche implicato nelle risposte infiammatorie ed è stato studiato per le sue potenziali applicazioni terapeutiche in condizioni come emicranie e altri disturbi del dolore. La sua attività biologica è mediata attraverso recettori specifici, noti come recettori CGRP, che sono recettori accoppiati a proteine G. Il numero CAS 90954-53-3 identifica univocamente questa sostanza nelle banche dati chimiche, facilitando la ricerca e lo sviluppo in farmacologia e biochimica.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

InChI: InChI=1/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

Sinonimi:

• Calcitonin Gene-Related Peptide-I, Human
• Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-Nh2

Calcitonin Gene Related Peptide, Human

CAS: 90954-53-3

For cellular and molecular biology applications

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Peso molecolare: 3789.3

Ref: 02-J65667

α-CGRP (human)

CAS: 90954-53-3

Bachem ID: 4013281.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purezza: 97.62%

Colore e forma: White

Peso molecolare: 3789.36

Ref: 01-4013281

α-CGRP(human)

CAS: 90954-53-3

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 3789.33

Ref: TM-TP2044

CGRP (Human)

CAS: 90954-53-3

Human CGRP with a disulfide bond between Cys2-Cys7 and available as a 0.1mg vial. CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purezza: Min. 95%

Peso molecolare: 3,789.3 g/mol

Ref: 3D-PCG-4160-S

CGRP (Human)

CAS: 90954-53-3

CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.
This product is available as a 0.5mg vial.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purezza: Min. 95%

Peso molecolare: 3,789.3 g/mol

Ref: 3D-PCG-4160-V