CAS 91-80-5

Metapirilene

Descrizione:

Metapirilene è un antistaminico e sedativo appartenente alla classe di composti noti come alchilamine. Viene utilizzato principalmente per le sue proprietà antistaminiche, che aiutano ad alleviare le reazioni allergiche e sintomi come starnuti, naso che cola e prurito. Metapirilene è caratterizzato dalla sua capacità di attraversare la barriera ematoencefalica, il che contribuisce ai suoi effetti sedativi. Il composto ha una solubilità relativamente bassa in acqua, ma è solubile in solventi organici, rendendolo adatto per varie formulazioni farmaceutiche. Il meccanismo d'azione di Metapirilene implica l'antagonismo dei recettori H1 dell'istamina, inibendo così gli effetti fisiologici dell'istamina. Sebbene sia stato utilizzato in alcuni farmaci da banco, il suo uso è diminuito a causa di preoccupazioni riguardanti potenziali effetti collaterali, inclusi sedazione ed effetti anticolinergici. Come con molti antistaminici, si consiglia cautela nell'uso di Metapirilene, in particolare in popolazioni sensibili agli effetti sedativi, come gli anziani o coloro che operano macchinari.

Formula: C₁₄H₁₉N₃S

InChI: InChI=1S/C14H19N3S/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14/h3-8,11H,9-10,12H2,1-2H3

InChI key: InChIKey=HNJJXZKZRAWDPF-UHFFFAOYSA-N

SMILES: N(CC1=CC=CS1)(CCN(C)C)C2=CC=CC=N2

Sinonimi:

• 1,2-Ethanediamine, N,N-dimethyl-N′-2-pyridinyl-N′-(2-thienylmethyl)-
• 1,2-Ethanediamine, N¹,N¹-dimethyl-N²-2-pyridinyl-N²-(2-thienylmethyl)-
• 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine
• A 3322
• Ah 42
• Dimethyl[2-[(pyridin-2-yl)[(thien-2-yl)methyl]amino]ethyl]amine
• Histadryl
• Lulamin
• Metapyrilene
• N,N-Dimethyl-N′-pyrid-2-yl-N′-2-thenylethylenediamine
• N,N-dimethyl-N-2-pyridyl-N-2-thenylethylenediamine
• N-(α-Pyridyl)-N-(α-thenyl)-N′,N′-dimethylethylenediamine
• N¹,N¹-Dimethyl-N²-2-pyridinyl-N²-(2-thienylmethyl)-1,2-ethanediamine
• Paradormalene
• Pyridine, 2-[[2-(dimethylamino)ethyl]-2-thenylamino]-
• Pyrinistab
• Pyrinistol
• Rest-on
• Restryl
• Semikon
• Sleepwell
• Tenalin
• Thenylene
• Thenylpyramine
• Thionylan
• 1,2-Ethanediamine, N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)-

Methapyrilene

Prodotto controllato

CAS: 91-80-5

Applications Methapyrilene is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.
References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981); Eastmond, D., et al.: Mutagenesis, 24, 341 (2009); Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010)

Formula: C₁₄H₁₉N₃S

Colore e forma: Colourless To Yellow

Peso molecolare: 261.39

Ref: TR-M259998

Methapyrilene Dihydrochloride

Prodotto controllato

CAS: 91-80-5

Applications Methapyrilene Dihydrochloride is a hydrochloric salt derivative of methylpyrilene which is used as antihistaminic agent.
References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981), Eastmond, D., et al.: Mutagenesis, 24, 341 (2009), Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010),

Formula: C₁₄H₁₉N₃S·2(HCl)

Colore e forma: Neat

Peso molecolare: 261.39 + (36.46)

Ref: TR-M259945

Methapyrilene dihydrochloride

CAS: 91-80-5

Methapyrilene dihydrochloride is an anticancer drug that acts as a kinase inhibitor, preventing the activation of protein kinases that are involved in cancer cell growth and survival. It has been shown to induce apoptosis (cell death) in cancer cells by inhibiting the activity of certain kinases. Methapyrilene dihydrochloride is a potent inhibitor of tumor growth in Chinese hamsters, human tumors, and other animal models. It is also an analog of amphetamine and can be detected in urine tests. This drug has shown promising results as a potential treatment for various types of cancer.

Formula: C₁₄H₁₉N₃S

Purezza: Min. 95%

Peso molecolare: 261.39 g/mol

Ref: 3D-AAA09180

Methapyrilene

CAS: 91-80-5

Methapyrilene is a histamine H1 antagonist with sedative action.

Formula: C₁₄H₁₉N₃S

Colore e forma: Liquid Physical Description Clear Colorless Liquid (Ntp 1992)

Peso molecolare: 261.39

Ref: TM-T28026