CAS 91224-37-2

(D-arg1,D-trp7,9,leu11)-sostanza P*acetato

Descrizione:

(D-arg1,D-trp7,9,leu11)-sostanza P*acetato, con il numero CAS 91224-37-2, è un analogo sintetico della sostanza P, un neuropeptide coinvolto in vari processi fisiologici, inclusa la percezione del dolore e l'infiammazione. Questo composto è caratterizzato dalla sua sequenza di amminoacidi modificata, che include D-arginina in posizione 1, D-triptofano nelle posizioni 7 e 9, e leucina in posizione 11, migliorando la sua stabilità e affinità di legame ai recettori rispetto al peptide naturale. Il componente acetato indica che il composto è nella sua forma di sale acetato, il che può influenzare la sua solubilità e biodisponibilità. Tipicamente, tali analoghi vengono studiati per le loro potenziali applicazioni terapeutiche, in particolare nella gestione del dolore e nella neurobiologia, grazie alla loro capacità di interagire con i recettori della neurochinina. Le modifiche strutturali mirano a migliorare le proprietà farmacologiche riducendo al contempo la suscettibilità alla degradazione enzimatica. In generale, questo composto rappresenta un interesse significativo nella chimica medicinale e nella farmacologia per lo sviluppo di nuovi trattamenti mirati ai percorsi dei neuropeptidi.

Formula: C₇₅H₁₀₈N₂₀O₁₃

InChI: InChI=1/C75H108N20O13/c1-42(2)35-55(64(80)98)89-67(101)56(36-43(3)4)90-69(103)59(39-46-41-85-51-23-11-9-20-48(46)51)93-68(102)57(37-44-17-6-5-7-18-44)91-70(104)58(38-45-40-84-50-22-10-8-19-47(45)50)92-66(100)52(27-29-62(78)96)86-65(99)53(28-30-63(79)97)87-71(105)61-26-16-34-95(61)74(108)54(24-12-13-31-76)88-72(106)60-25-15-33-94(60)73(107)49(77)21-14-32-83-75(81)82/h5-11,17-20,22-23,40-43,49,52-61,84-85H,12-16,21,24-39,76-77H2,1-4H3,(H2,78,96)(H2,79,97)(H2,80,98)(H,86,99)(H,87,105)(H,88,106)(H,89,101)(H,90,103)(H,91,104)(H,92,100)(H,93,102)(H4,81,82,83)/t49-,52?,53+,54+,55+,56?,57+,58-,59-,60?,61?/m1/s1

Sinonimi:

• (D-Arg1,D-Trp79,Leu11)-Substance P
• H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
• D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 Hydrochloride

(D-Arg¹,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 91224-37-2

Spantide I, a high potency substance P antagonist with a weak spasmogenic and a poor histamine releasing effect.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purezza: 95.2%

Colore e forma: Beige Powder

Peso molecolare: 1497.81

Ref: 01-4004691

[D-Arg1, D-Trp7,9, Leu11]-Substance P

CAS: 91224-37-2

Formula: C₇₅H₁₀₈N₂₀O₁₃

Peso molecolare: 1497.79

Ref: 7W-GL0691

Spantide I

CAS: 91224-37-2

Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1497.79

Ref: TM-T20413

[D-Arg1,D-Trp7,9,Leu11]-Substance P

CAS: 91224-37-2

This product is a Substance P antagonist in the Hydrochloride salt from and as a 0.5mg vial. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator. It is best known for its role in nociception or pain perception. Substance P is also involved in other biological processes such as the regulation of gastrointestinal motility and the inflammatory response. As a tachykinin neuropeptide, substance P acts through binding to its specific neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is also involved in: increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purezza: Min. 95%

Peso molecolare: 1,497.8 g/mol

Ref: 3D-PSP-4173-V

(D-Arg1,D-Trp7·9,Leu11)-Substance P

CAS: 91224-37-2

Substance P is a neuropeptide that is involved in the transmission of pain signals from the nerves to the brain. It also has been implicated in inflammatory and autoimmune diseases. Substance P is a potent agonist of the neurokinin-1 receptor, which causes an increase in intracellular calcium ion levels, leading to neuronal excitation. The release of substance P from nerve fibers can be blocked by administration of an analog (e.g., N-acetyl-D-Arg1,D-Trp7·9,Leu11)-substance P H-D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu -Leu -NH2). This compound blocks the activation of substance P receptors with high affinity and specificity.

Formula: C₇₅H₁₀₈N₂₀O₁₃

Purezza: Min. 95%

Peso molecolare: 1,497.79 g/mol

Ref: 3D-FA108555