CAS 914-00-1

Metaciclina

Descrizione:

Metaciclina è un antibiotico semisintetico appartenente alla classe delle tetracicline, caratterizzato dalla sua attività antibatterica ad ampio spettro. È principalmente efficace contro una varietà di batteri Gram-positivi e Gram-negativi, così come alcuni protozoi. Metaciclina è noto per la sua capacità di inibire la sintesi proteica batterica legandosi alla subunità ribosomiale 30S, impedendo così la traduzione dell'mRNA. Questo composto viene tipicamente somministrato per via orale ed è utilizzato nel trattamento di varie infezioni, comprese le infezioni delle vie respiratorie e le infezioni cutanee. Metaciclina presenta una struttura relativamente stabile, che gli consente di mantenere l'efficacia in presenza di alcuni meccanismi di resistenza batterica. Inoltre, ha una solubilità moderata in acqua ed è spesso formulato in varie forme di dosaggio per uso clinico. Come altre tetracicline, può causare effetti collaterali come disturbi gastrointestinali e fotosensibilità. A causa del suo potenziale per lo sviluppo di resistenza, è necessaria una considerazione attenta quando si prescrive Metaciclina, e spesso viene utilizzato in combinazione con altri agenti terapeutici.

Formula: C₂₂H₂₂N₂O₈

InChI: InChI=1/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25-27,31-32H,1,23H2,2-3H3/b21-13+/t10-,14-,15+,17+,22+/m1/s1

InChI key: InChIKey=MHIGBKBJSQVXNH-IWVLMIASSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C(C3=C)=CC=CC4O)[H])[H]

Sinonimi:

• (4S,4aR,5S,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4α,4aα,5α,5aα,12aα)]-
• 4-Dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide
• 6-Demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline
• 6-Deoxy-6-methylene-6-demethyl-5-hydroxytetracycline
• 6-Methylene-5-hydroxy-tetracycline
• 6-Methylene-5-hydroxytetracycline
• 6-Methyleneoxytetracycline
• Bialatan
• Gs 2876
• Metaciclina
• Metacyclin
• Metacycline
• Methacycline
• Oxytetracycline, 6-methylene-
• Rondomycin
• Tri-methacycline
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, (4S,4aR,5S,5aR,12aS)-
• (2Z,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• (2E,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylidene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
• ,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
• 6-Methyleneoxytetracycline, Metacycline, RondoMycin
• Doxycycline Impurity 2(Doxycycline EP Impurity B)
• 12aalpha))-ph
• 6-methylene-oxytetracyclin
• 10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,(4s-(4alpha,4aalpha,5alpha,5aal
• methacyclinebase
• 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline
• 6-methylene-5-oxytetracycline
• methacyclineamphoteric
• METHACYCLINE USP/EP/BP

(4S,4aR,5S,5aR,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methylidene-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

CAS: 914-00-1

Formula: C₂₂H₂₂N₂O₈

Purezza: 90%

Colore e forma: Solid

Peso molecolare: 442.4187

Ref: IN-DA01DN9X

Doxycycline EP Impurity B

CAS: 914-00-1

Formula: C₂₂H₂₂N₂O₈

Peso molecolare: 442.42

Ref: 4Z-D-1812

Methacycline

CAS: 914-00-1

Impurity Doxycycline EP Impurity B
Applications Methacycline is a tetracycline with broad range antibacterial and antiprotozoal properties. Potential veterinary drug.
References Li, J. et al: J. Sep. Sci., 41, 4115 (2018); Tejada-Casado, C. et al.: Anal. Chim. Act, 1043 (52 (2018);

Formula: C₂₂H₂₂N₂O₈

Colore e forma: Off-White

Peso molecolare: 442.42

Ref: TR-M258788

Methacycline

CAS: 914-00-1

Methacycline, a tetracycline antibiotic, inhibits bacterial protein synthesis and effectively suppresses epithelial-mesenchymal transition (EMT). It blocks EMT in vitro and inhibits fibrogenesis in vivo without directly affecting the TGF-β1Smad signaling pathway. As an antimicrobial agent, Methacycline holds potential for research in pulmonary fibrosis.

Formula: C₂₂H₂₂N₂O₈

Colore e forma: Solid

Peso molecolare: 442.42

Ref: TM-T201726