CAS 92309-29-0

Miscela di imipenem-cilastatina

Descrizione:

Imipenem-cilastatina è un antibiotico combinato utilizzato principalmente per il trattamento di gravi infezioni batteriche. L'imipenem è un antibiotico ad ampio spettro appartenente alla classe dei carbapenemi, efficace contro un'ampia gamma di batteri Gram-positivi e Gram-negativi, comprese molte ceppi resistenti. La cilastatina è un inibitore della deidropeptidasi renale che previene la degradazione dell'imipenem nei reni, migliorando così la sua efficacia e riducendo la nefrotossicità. La combinazione è particolarmente utile nel trattamento di infezioni causate da organismi multiresistenti. L'imipenem-cilastatina viene tipicamente somministrato per via endovenosa ed è indicato per condizioni come polmonite, infezioni intra-addominali e infezioni del tratto urinario. La farmacocinetica di questa miscela comporta una rapida distribuzione nei tessuti corporei, con una emivita relativamente breve, richiedendo più dosi per livelli terapeutici sostenuti. Gli effetti avversi possono includere disturbi gastrointestinali, reazioni allergiche e, meno comunemente, convulsioni, in particolare nei pazienti con insufficienza renale. In generale, l'imipenem-cilastatina è un'opzione critica nell'arsenale degli antibiotici, specialmente per infezioni gravi in cui altri trattamenti possono fallire.

Formula: C₂₈H₄₃N₅O₉S₂

InChI: InChI=1/C16H26N2O5S.C12H17N3O4S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/b12-6-;/t10-,11-;6-,7-,9-/m11/s1

InChI key: InChIKey=NCCJWSXETVVUHK-ZYSAIPPVSA-N

SMILES: C(N/C(=C\CCCCSC[C@@H](C(O)=O)N)/C(O)=O)(=O)[C@@H]1C(C)(C)C1.C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])(CC1SCCNC=N)[H]

Sinonimi:

• (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid - (5R,6S)-3-[(2-{[(1E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (1:1)
• (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid - (5R,6S)-3-[(2-{[(E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate (1:1:1)
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, [5R-[5α,6α(R*)]]-, mixt. with [R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
• 2-Heptenoic acid, 7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-, [R-[R*,S*-(Z)]]-, mixt. contg.
• 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, (2Z)-, mixt. contg.
• Cilastatin-imipenem mixt.
• Imipenem-cilastatin mixt.
• Primaxin
• Primaxin IV
• Sodium (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
• Tainem
• Tienam 500
• 7-[(2S)-2-amino-2-carboxy-ethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopro panecarbonyl]amino]hept-2-enoic acid: (5R)-3-[2-(aminomethylideneamino )ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene -2-carboxylic acid
• Mk 787-mk 791 mixture
• Mk 0787-mk 0791 mixture
• IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate
• 85960-17-4 (Hydrochloride salt)
• 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R-(5alpha,6alpha(R*)))-, mixt. with (R-(R*,S*-(Z)))-7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptanoic acid
• Thienam
• Imipenem-Cilastatin sodium hydrate USP/EP/BP

Imipenem-cilastatin sodium hydrate, Antibiotic for Culture Media Use Only

CAS: 92309-29-0

Imipenem-cilastatin sodium hydrate is a fine chemical that belongs to the category of research chemicals. It is a complex compound and versatile building block with a wide range of applications in research, development, and production of pharmaceuticals. Imipenem-cilastatin sodium hydrate has been used as a reagent for the synthesis of other compounds, as well as an intermediate for various reactions or as a scaffold for drug discovery. It is also useful in the preparation of high quality speciality chemicals.

Formula: C₂₈H₄₄N₅NaO₁₀S₂

Purezza: 40 To 60 Area-%

Colore e forma: White Powder

Peso molecolare: 697.8 g/mol

Ref: 3D-FI148817